Chapter 211 Act on the spot! (Please subscribe!)

After returning to the rental house, Zhou Cheng was not in a hurry to open the data that Ding Dian had given him before. Instead, he first recalled the basic skills he had acquired!

Medical statistics (skilled), medical epidemiology (skilled).

Scientific research is not something lofty, nor is it metaphysics that exists apart from reality! It is a down-to-earth process of exploring possible answers to a question through certain methods and experiments.

When writing an article, no matter what kind of article it is, in fact, the two disciplines of medical statistics and medical epidemiology are basic methods. To write a good article, these two subjects must be solid.

At least in the process of writing medical-related articles, a solid theoretical foundation is needed.

Theory guides practice——

The definition of medical statistics is a discipline that uses the principles and methods of probability theory and mathematical statistics, combined with medical practice, to study the collection, analysis and inference of digital data. The objects of medical research are mainly the human body and related to human health.

various factors.

The definition of medical epidemiology is the discipline that studies the distribution of diseases and health conditions among the population and their influencing factors, and explores strategies and measures to prevent diseases and promote health.

To put it more simply, the direct object of medical epidemiology is the population. We should establish the direction of the subject among the population and obtain basic data. After obtaining the basic data, we must use the method of medical statistics to

The data is processed into conclusions with practical medical significance!

To put it more simply, medical epidemiology is to digitize disease conditions, while medical statistics is to abstract and theorize data!

Any article, in the final analysis, no matter how it changes, it will never deviate from its origin!

However, although the basics are enough, you still have to go through the applied process step by step.

This process is like getting the decoration materials to your home, but how to decorate it and how to decorate it on the walls is a process-based technical issue.

Basically all medical undergraduates will understand medical statistics and epidemiology, but whether they can apply it flexibly is another matter.

Of course, what Zhou Cheng is thinking about now is not this. He feels that if he starts writing a treatise type article directly, he may be lacking in skills. It is better to be like Gongsun Su and write an article first.

Meta-analysis or review.

First try the whole process of writing an article. After you are familiar with the whole process, then start writing articles of the type that are more difficult than meta-analysis. Only in this way can you complete the early accumulation.

If you insist on writing a basic research article, it's not impossible, but it will definitely require many revisions.

A sharpened knife will never stop chopping wood.

Now that you have decided to study well, you must first sharpen your tools if you want to do your job well!

Meta-analysis is not a basic course in the subject of medical statistics. At least in the undergraduate teaching process, there is no exam. However, although it does not participate in the final exam, it is a comparative subject for you to participate in social exams.

A simple and easy to learn subject.

Meta-analysis is a statistical method used to compare and synthesize research results on the same scientific issue. Whether its conclusions are meaningful depends on the quality of the included studies. It is often used for quantitative combined analysis in systematic reviews.

Compared with a single study, by integrating all relevant studies, the effect of medical and health care can be estimated more accurately, and it is conducive to exploring the consistency of evidence from each study and the differences between studies.

When the results of multiple studies are inconsistent or have no statistical significance, meta-analysis can be used to obtain statistical analysis results that are close to the real situation.

Medical statistics is a discipline of evidence-based medicine. In terms of the classification of evidence levels in evidence-based medicine, meta-analysis is a relatively reliable one.

This is a discipline that has only emerged in the last twenty years. Its main method of use is to reuse data from previous studies, especially randomized controlled trials (RCT). By integrating data from multiple RCTs, we can obtain

More credible results.

Because of the emergence of meta-analysis, many previous RCT articles have regained new vitality.

However, in the past decade or so, due to the emphasis on scientific research and the development of medical statistics, meta-analysis has gradually begun to spread, and it is difficult to meet the needs of the development of the discipline with just two intervention measures.

This is where network meta-analysis comes into play.

Zhou Cheng then set a small goal for himself, that is, should he write a network meta-analysis first?

The definition of network meta-analysis is based on the meta-analysis of indirect comparison or the combined results of indirect comparison and direct comparison to analyze two or more interventions at the same time.

Including the following two situations: ① Adjusted indirect comparison meta-analysis: when there is no direct comparison, meta-analysis comparing multiple interventions based on common controls; ② Mixed treatment effects...

When you want to write an article, it is difficult to find a random direction to write in.

But, that is for others, Zhou Cheng, as a 'male silver' with more than 100 perfect levels of skills, does not have so many worries, because he can find an 'improvement' of any surgical method.

A good article can be written by comparing the formula with the traditional technique.

For example, Zhou Cheng quickly found several very good RCTs on the treatment of hip tuberculosis cases, but there was no unified standard.

…

Zhou Cheng screened for a while, but after failing to find the corresponding meta-analysis, he decided to write in this direction. After the general direction was determined.

There are more things that can be written in a small direction.

Because the treatment methods for patients with hip tuberculosis are generally divided into three types.

Traditional hip fusion, hip replacement, amputation.

Amputation must have been abandoned long ago.

Hip replacement surgery is further divided into primary replacement or secondary replacement.

Just these few points are enough to write a network meta, because if the data is enough, it can be divided into other subgroups.

Um.

The direction is determined. After determining the direction, the next thing to do is to find all the RCTs that can be found!

That is to say, all RCT articles on the treatment of hip tuberculosis must be included. Whether they are in Chinese or English, as long as you know them, you must find them, even if you know French, German, Japanese, Korean, etc.

Etc., you can include all data on hip tuberculosis from all countries.

Of course, if you don’t know other languages, you should at least include all the literature in English!

This is the basic rule. When looking for RCT articles, you have to explore slowly, determine keywords, extract articles, read the full text, and determine the article type. If it is other types of articles, such as case report (case report)

report), discard it directly.

System review should also be discarded directly.

If it is an RCS, that is, a retrospective controlled study, it will be treated tentatively.

Retrospective controlled studies have too much selection bias and are not as convincing as RCTs!

…

This process was very tedious. Zhou Cheng was busy until eleven o'clock before he managed to search out all the articles. Then Zhou Cheng did not continue, but turned off the computer and quickly started a new round of simulation!

Zhou Cheng’s purpose for today’s simulation is very clear, and there are three main directions.

In the first simulation, Zhou Chenggong was very clear-minded in the simulated world. Before Luo Yun took the doctoral entrance examination organized by Shanghai Jiao Tong University, someone deceived Luo Yun's mother out of the hotel, and then let her

After the hotel contacted Luo Yun about her disappearance, it turns out that Luo Yun failed the exam!

In this simulation, Mr. Zeng was even more angry!

Sure enough, this time, unexpected changes happened faster.

The accident happened just one month after the incident.

However, this time it did not affect Zhou Cheng, who smoothly obtained a perfect level III skill.

This made Zhou Cheng confirm one thing again, that is, the current Mr. Zeng is really too interested in Luo Yun and hopes that Luo Yun can come to the Magic City. It is precisely because of this that Mr. Zeng is very angry.

, and as a result, I accidentally exposed the topic of my Ph.D. brother.

Immediately afterwards, Zhou Chengcheng immediately started the second simulation!

In this simulation, Zhou Cheng rushed directly into Professor Liu Yiping's department at the beginning, and then started a "Taishan overwhelming" routine with the force of being able to hide his ears and steal the bell.

Then in just half a month, Mr. Zeng was blown up!

Because the entrance exam for doctoral students is in March of the next year, and during this process, Mr. Zeng often wandered around the clinic, and became familiar with Zhou Cheng!

When Luo Yun failed the exam again, something unexpected happened!

[Your mentor gives sincere advice to your ‘senior brother’, asking him to come back next year!]

【……】

"Ah!~This?" Zhou Cheng was stunned.

Mr. Zeng, an academician, is he also such a snobbish person?

Then, this time the simulation process went even more smoothly. With the support of Mr. Zeng, Zhou Cheng really stood at the forefront of the times. At the age of fifty, he successfully became a dual-disciplinary academician, and

Won the second largest award after the Nobel Prize.

It can be considered very comfortable.

I once again got an innovative skill - hip arthroscopy hip preservation surgery (perfect - groundbreaking)!

Then during the third simulation process, Zhou Cheng tried it again and found that the initial skills he carried were not very good, and then went to Professor Liu Yiping and Mr. Zeng to show their courtesy!

The final result was that Zhou Cheng was kicked out of the clinic in the second week of clinical practice. Then Zhou Cheng became an ordinary master's student, and Luo Yun took Zhou Cheng's place as a doctoral student!

Because there is no special limit on the number of master’s students——

Fortunately, Zhou Cheng's simulation idea this time is to learn medical English, so it doesn't matter whether he is in clinical practice or not.

After Zhou Cheng graduated with a master's degree, he was kicked out of the hospital and returned directly to his original province and found a prefecture-level city for retirement.
To be continued...