Chapter 041 Cells Are the Masters of Life
When Rashid heard the statement of "Life Diary", he couldn't help but lose his mind.
Since conquering the human genome, two new disciplines of genomics and bioinformatics have been born, and new breakthroughs have been made in the treatment of diseases, such as genetic diagnosis and gene therapy: medical scientists have mastered genome knowledge and got rid of the traditional method of heavy treatment (treatment only after discovering diseases) and switched to heavy prevention (using genetic diagnosis to predict the occurrence of diseases in advance, thereby improving prevention). All of this is the great confidence brought to Rashid by conquering the human genome. He has reason to believe that as long as the human genome is completely cracked, the human disease problem will be completely solved.
However, all this was not as smooth as expected. Although the gene map was successfully drawn, in the process of cracking the human genome, there were still many problems that were unclear and difficult to study.
Therefore, when he heard Fujiwara not marrying, "DNA is just a diary recorded by cells", Rashid was stunned: I really hope that Fujiwara not marrying is right, and can solve the problems he encountered that he cannot study; at the same time, I hope that Fujiwara not marrying is wrong, and the human genome project is of great significance. If it is overthrown or denied, it will be the sorrow of the biological world...
"What is the evidence that DNA is a life diary in a cell?"
Zach also asked curiously.
"As far as I understand, isn't DNA more like a cryptobook? A cryptobook about living things."
Harem interrupted and said:
"In DNA macromolecules, the three adjacent bases in DNA are represented by a codon. Any three bases arranged adjacently in the DNA molecule form a triplet code. Each triplet code has a certain meaning. Some represent the beginning of transcription, some represent the termination of transcription, but most represent the code of an amino acid. Senior Rashid, am I right?"
After all, Rashid is an expert in this field, so after Harem finished speaking, he would confirm with Rashid.
Rashid nodded, expressed confirmation, and added:
"There are 5 common bases in organisms, and the letters are represented by A, G, C, T, and U. According to the rules of triad code compilation, each three form a group, and there are 64 combinations."
Each combination encodes a corresponding amino acid, except for the three triplets that do not encode any amino acids (they represent stop or meaningless codons, namely UAA, UGA and UAG, respectively), 64 combinations minus 3, and 61 combinations.
These 61 combinations should encode 61 amino acids.
In fact, there are only 20 amino acids.
The reason is that some amino acids can actually be encoded by several different combinations. That is, among the 61 combinations, some combinations actually encode the same amino acids.
This shows that some of the 64 combinations in total are "repetitive" and "redundant".
"The seniors participated in the Human Genome Project. Are there any such questions in the process?"
Fujiwara didn't directly answer the question, but instead asked Rashid:
"Why are some of the 64 combinations 'redundant'?"
Rashid nodded:
"Yes, I've had such a question."
This is exactly the problem that Rashid encountered that he was difficult to explain and could not study thoroughly... After pausing for a moment, Rashid said again:
"My bigger doubt is the genetic information of the entire DNA. Fragments with genetic effects in human DNA sequences only account for about 10%. The genetic effect mentioned here not only refers to the part that directly participates in protein mutation (only 5% of the genes that really play a decisive role), but also includes sequences similar to promoters and terminators that play auxiliary roles. That is to say, most of our DNA does not participate in recording and expressing genetic information, and 90% are junk DNA. Yes, 90% are junk DNA!"
Rashid reiterated that "90% belongs to garbage DNA", which shocked the players present!
——In DNA, up to 90% of the parts are "useless" and "supple"!
Cells cannot achieve the process from "none" to "existence" or from "small" to "big" like seeds germinate. The only way to give birth to cells is through cell division.
——It is necessary to divide on the existing cells before new cells can be born! It cannot give a "seed" to develop cells. Even cell culture technology is based on cell cloning, that is, it must provide the original cells.
Therefore, cell division is the only way to give birth to new cells.
Cell division is so important. During the process of cell division, in order to obtain 100% genetic information, the DNA in the cell nucleus must be faithfully replicated. As a result, "there is 90% garbage DNA in it"?
This really makes genetic experts puzzled!
——After such a high standard of copying, the target object is all redundant garbage! Only 10% of the useful ones account for!
"We found that junk DNA contains important regulatory mechanisms that can control basic biochemical reactions and developmental processes, which will help organisms evolve into more complex organisms. The more complex the organisms, the more important the junk DNA seems to be."
Rashid said more puzzled and more puzzled:
"We can't explain why these junk DNA still work? And there are so many quantities and so many specific gravity!!"
Rashid said this, his frustrated expression was completely different from his previous confident look.
"Mr. Fujiwara is an expert in the cell field and can definitely explain the doubts of senior Rashid."
Zach looked at Rashid, then saw Fujiwara not marrying, and said to Fujiwara not marrying with expectant eyes.
"I just said that DNA is just a gene memory, and genes are just a kind of genetic information. They cannot be the master of life. The real master of life is the cell. The first cell born on the earth evolved in its adaptation to the environment and long-term struggle with the environment. The earth's environment was extremely unstable, so the environment often changed. In order for the "descendants" to adapt to a new environment from birth, and to be with the "survival ability" from birth to defend themselves, the mother cell wrote the evolutionary information into the "diary". Then when the cells divide, according to the surrounding environment, read the diary and decide what new cells will be born."
Fujiwara told the story of her unmarried story, and she was like telling a story. The team members were both surprised and suspicious!
"I feel like listening to fairy tales?"
"Think about it carefully, it seems like this is the case."
The team members whispered... You should know that fairy tales are all lies!
"So, cells evolved with the changes in the environment, and continued to evolve, and kept writing diaries unremittingly, eventually forming various species, and the diary in their bodies became such a thick book today?"
Tang Qi made a summary statement, and did not forget to tell stories in the same style:
"From small single-celled organisms and bacteria, to plants, animals and even humans, these species gathered together today and took out their diary, and they all looked amazing."
Tang Qi's words caused the team members to laugh out loud.
But no matter how much I smile, no one thinks it is a joke.
Everyone is engaged in scientific research, and they can still distinguish between true and false. The alternative interpretation of Fujiwara's failure to marry is at least not contrary to the facts - the current situation of cells is indeed the case, but genetic experts put DNA first, and Fujiwara's failure to marry is the first, with different positions.
"Mr. Fujiwara regards DNA as a diary written by cells, so why are we genetic experts interpreting the gene code of organisms?"
Rashid asked:
"And this interpretation is not a wishful interpretation. At least after we interpret it, it will be effectively applied. For example, it has also achieved remarkable results in medical treatment, solving some diseases that were originally unsolvable and conquering some medical problems that were originally unsolvable."
Rashid's words brought the team members to their senses.
Indeed, if DNA is regarded as a diary written by a cell, how can the genetic code be interpreted? And at least these genetic codes have been proven to be effective!?
"My research on cells is not in-depth enough, and I haven't studied it for a long time. I can't fully master the language of cells and I can't completely translate its diary. I can only give you an explanation like this-"
Fujiwara's unmarried life is like Fabre possessed, and he devoted his life to cell research. He even said that he was "not deep enough" and "not long"!?
Just listen to him continue:
"This is how the cell writes a diary: what it eats today, what reactions the body has, and which part differentiates what substances. What help these substances will help me tomorrow is unknown. On the second day, the cell examines the role of these substances. If it helps, it stays, and how it is helpful. It will analyze the detailed process of the reaction between these substances and its body; if it does not help, it will excrete, or it will damage it, and analyze how to deal with it... and then record all of this in the diary. In this diary, there are very few words that can determine genetic information when it really mentions the information of the cell body."
After Fujiwara said that he would not marry, he looked at Rashid and said:
"This is the 10% useful gene and 90% garbage DNA you interpret in DNA. When cells divide daughter cells, they will re-examine the surrounding environment, such as confirming that some substance often appears in this environment, and this substance is harmful to the cells. Then when the cells divide, they will search for the diary and find records of how they react in this environment, and extract the corresponding "reaction mechanism" as a "survival ability" and give it to daughter cells. In this way, once the daughter cells divide, they can directly deal with the new environment."
The commentator of Fujiwara's failure to marry surprised the team members.
Regarding the cell, the team members asked themselves that they would not marry Fujiwara, and his commentary sounded like that, so the team members were only surprised and could not refute or question.
"In other words, the genetic information we humans interpret is actually what cells unintentionally release to us - because when the gene is touched in the struggle with the environment, the cells will "expose" the genes that are 'touched' in their self-analysis, that is, write them in their diary. And what is not written in their diary may be more, that is, the recessive genes or unknown genes mentioned by gene experts."
Rashid kept listening carefully. At first, he didn't agree, but in the end, he completely turned into a look of shock.
When he was studying the human genome, he did encounter this problem, such as overlapping gene problems, allelic problems, and recessive gene problems. Now when he heard the alternative interpretation of Fujiwara's not marrying, he interpreted it from the perspective of the cell as the master, and he immediately understood it.
...Can cells are the masters of life? At this moment, Rashid fell into a state of distraction and was stunned.
Chapter completed!