Splix Research Institute, Office of the Chair, Department of Neurobiology.

Professor Bruce looked through the information in his hand with an extremely focused expression. His eyes moved slowly line by line on the paper, and it took him a long time to turn over the page.

"Jingle Bell......"

After the phone on the table rang several times, he grabbed the phone impatiently and after listening to a few words, he said solemnly: "Let him wait for half an hour... No! Come back in an hour!"

After saying that, he put down the phone with a bang and immediately turned his attention back to the information in his hand.

After another ten minutes, Professor Bruce put down the materials in his hands with a solemn expression, and looked at the young man sitting on the chair in front of him with surprise: "Is this the result of your research in the past six months?"

"Yes, sir!"

Tian Lu moved his body slightly and answered solemnly.

"Are there any detailed experimental records?" Professor Bruce asked urgently.

"Of course, sir!"

Tian Lu quickly took out a stack of thick printing paper from his wallet, stood up and handed it to Professor Bruce. He grabbed Tian Lu's experimental records, and Professor Bruce couldn't wait to read them.

The sound of turning pages suddenly became the only sound in the quiet office!

"God!"

After flipping through the last page of printed paper, Professor Bruce was lost for a moment and then immediately raised his head and shouted almost in a low voice: "Do you know what this paper of yours means?"

"Yes, sir."

Tian Lu nodded.

"No! You don't know!"

Tian Lu raised his head in astonishment and watched Professor Bruce push the leather chair behind him, stood up excitedly and shouted: "If you knew the significance of this paper, you would never behave so calmly!"

Waving the experimental record data in his hand, Professor Bruce felt uncontrollable excitement and impulse in his heart!

If Tian Lu's article "Comparative Study on the Effects of Several Molecular Markers on Screening and Identification of Pericytes" three months ago only made him realize the potential of this young man and deserved more financial support, then now in his hands

The article "The Effect of Pericyte Autocrine Signaling Molecules on Endothelial Cells in Pericyte/Endothelial Cell Co-culture System" was even worthy of him setting up a research group for Tian Lu!

After just a moment of hesitation, Professor Bruce asked loudly: "According to the final prediction of the paper, how confident are you? How many manpower are needed? How long will it take?"

"With six laboratory technicians, sufficient financial support and the right to use equipment, I am sure to get the results within two months!" Surprised in his heart, Tian Lu said the answer he had planned for a long time without thinking!

"very good!"

Professor Bruce waved his right arm fiercely and said decisively: "Within two days, no! The technical staff you requested will be in place tomorrow! In addition, I will inform you that your experimental animal supply and equipment use have priority!"

"Thank you very much, sir!"

The excitement that had been suppressed in his heart finally could no longer be concealed. Tian Lu stood up with an ecstatic expression and solemnly said: "I promise you that I will give you a perfect answer within two months!"

"Um!"

Professor Bruce nodded heavily, shook the materials in his hand and said, "You go back and prepare first. I will keep these materials here. When the experiment is successful, we will send them for publication together!"

After hearing this, Tian Lu nodded gratefully to the other party, and immediately stood up and walked out. After receiving the most perfect reply, he couldn't wait to prepare for the research plan for the next two months.

Looking at Tian Lu disappearing at the door, Professor Bruce walked quickly back and forth in the office for a moment before returning to his seat and slowly sitting down.

He couldn't help but cast his gaze again at the pile of printing paper in his hand, with a sparkling look in his eyes: This is a new discovery that is no worse than the new vascular growth factor and the small molecule synthesis that controls the fate of embryonic stem cells!

It is really unbelievable that in less than ten months, that young man has made such a huge achievement! The research method is not very innovative, nor does it use very sophisticated instruments and equipment, but it is just from a

Starting from an angle that ordinary people cannot imagine, Tian Lu unexpectedly discovered an inconspicuous road through the fog!

At least judging from Professor Bruce’s years of accumulated experience and sophisticated perspective, the possibility of this road successfully reaching the end is extremely high!

On the first day he met Tian Lu, when he saw his research plan, Professor Bruce never imagined that he would reach this point. But for a neurosurgery resident, in the laboratory,

His job is more about cultivating independent scientific research qualities, and the plan does have certain feasibility, so out of the idea of ​​encouraging young people, Professor Bruce agreed to Tian Lu's research plan.

Unexpectedly, he did it so quickly!

Once successful, it will add a lot to the honor list of the Department of Neurobiology at Splix Research Institute!

...

Back in his laboratory, Tian Lu couldn't wait to enter the system in his mind. While referring to the research plan he had already prepared, he started typing on the real computer.

He did not expect that this matter would progress so smoothly today. His original plan was to use this paper to successfully persuade Professor Bruce to provide more financial support. After all, for a training resident physician, his research

Funds are limited, and both the experimental materials and the experimental animals that will be used in the future are of great value. But what he didn't expect was that as soon as he saw the paper he had written, Professor Bruce would give him such a great gift.

support!

In ten months, no, to be precise, it should be seven months. Without any distractions, Tian Lu successfully completed the preliminary research.

For more than a hundred years, many scientists and pharmaceutical companies have been researching how to break through the blood-brain barrier by changing the structure of drugs so that they can attach to receptors and other molecules to break through. But what Tian Lu wants to do is

, directly by controlling the blood-brain barrier, allowing it to relax its shielding effect on certain substances, thereby achieving the same result!

This is easy to say, but of course not so simple in practice.

In fact, people have thought of this for a long time in reality, including research on pericytes. For example, it was discovered that smooth muscle contractile proteins expressed by pericytes, as well as **f-β, etc., can penetrate the blood-brain barrier.

Sex plays a certain role, but it either has strong side effects or is uncontrollable, and does not have much practical significance.

With the help of the system, Tian Lu directly eliminated countless possibilities, skipped thousands of experiments, and directly found the final result: a newly synthesized compound that can stimulate pericytes to express autocrine signals.

molecules to successfully open the blood-brain barrier!

And the most important thing is that this kind of opening is controllable!

By adjusting the concentration of the compound, the opening time of the blood-brain barrier can be perfectly controlled, and it can be closed smoothly after reaching certain requirements!

Tian Lu typed the keyboard excitedly, typing out the follow-up test plan page by page: establishing an endothelial cell-pericyte-astrocyte co-culture model to simulate the anatomical structure of the blood-brain barrier; establishing an experimental mouse animal model to conduct compound concentration tests

Experiments on the opening time of the blood-brain barrier, and a list of substances that can pass through the blood-brain barrier...

Tian Lu must speed up the progress of subsequent tests as much as possible!

After being prompted by the medical literature support system, Shimoda knew that in just a few months, the journal "Nature Neuroscience" would publish an article. Cornell University researchers discovered that: a molecule produced in the body of mice

——Adenine nucleoside receptors can control the entry of large molecules into the brain. When adenine nucleoside receptors are activated on the cells that make up the blood-brain barrier, a channel will be established to enter the blood-brain barrier. They also

They found that the myocardial perfusion contrast agent lexiscan, an adenine nucleoside-based drug approved by the U.S. Food and Drug Administration, can also easily open a channel through the blood-brain barrier. Next, they plan to explore ways to deliver drugs to treat brain cancer and

Better understand the physiological mechanisms behind adenine nucleoside receptor control of the blood-brain barrier.

Although the ideas of the two studies were inconsistent and the results were inconsistent, and future research showed that Tian Lu's method was more effective and safer, he still did not dare to be careless.

This is a series of studies. Being able to open the blood-brain barrier by controlling pericytes is only the first step. If you want to make this theory more systematic or even directly applied to clinical applications, the subsequent research content will be extremely huge: to obtain this

After the results and data that a compound affects the opening and closing of the blood-brain barrier, it is necessary to further study its mechanism of action and the mechanism of action of pericytes on the blood-brain barrier.

Of course, there are also the mechanisms of astrocytes' action on the blood-brain barrier, the action mechanism of endothelial cells on the blood-brain barrier, etc...

As for this research itself, it is difficult to bring any economic benefits to Tian Lu. After all, he uses existing substances and does not completely create a new substance.

But if you publish it one day earlier, you can get stronger support the day earlier!

After all, basic research has always been supported by the state, or research conducted with donations. For example, if Tian Lu's research results are successfully published, then he will definitely be able to apply for more support from the research institute, and even many pharmaceutical companies will

Take the initiative to offer large sums of research funding!

By successfully opening the blood-brain barrier, those pharmaceutical companies will be the ultimate beneficiaries.

And even if there is no profit, Tianlu will definitely gain fame!

For a researcher, reputation is more important than anything else. As long as there are results of sufficient weight, then there is no need to worry about future research facilities, equipment, and personnel support.

What's more, these are only a small part of what Tian Lu can do. As long as there is enough support, there are too many killer weapons in the future...
Chapter completed!