After telling the story, Fujioka Takamichi stood up and turned on the light. "Children, don't worry too much. Although this kind of bacteria is very dangerous, we are on an airship now. This kind of bacteria is not very contagious and should not be contagious."

On our heads."

"Qianha, what did he just say?" Mitsuhiko asked impatiently. "What about Gram stain, Gram-positive bacteria, cefazolin, vancomycin, etc..."

"Well, if you have to ask these questions..." Qianyu raised his eyebrows, and then looked at Haiyuan Ai. "You do this?"

"Briefly, Gram staining is a means of distinguishing types of aerobic bacteria. By this method, aerobic bacteria can be divided into two types: Gram-negative bacteria and Gram-positive bacteria," Haiyuan

Ai explained succinctly. "Cefazolin is a common antibiotic used to treat Gram-positive bacteria, while vancomycin is a heavyweight antibiotic used at the last minute against Gram-positive bacteria."

"Is vancomycin very powerful?" Mitsuhiko asked.

"It's amazing," Haibara Ai nodded. "So far, the example Mr. Fujioka mentioned should be a very rare bacterium that is resistant to vancomycin in the world - if it doesn't take effect, it's not because of vancomycin.

If the toxin doesn’t have time to penetrate deep into the body.”

"What is resistance?" Ayumi asked this time. "Why do bacteria become resistant to antibiotics that can kill them? Aren't antibiotics their nemesis?"

"In the end, they are just medicines," Haiyuan Ai smiled and shook his head. "Antibiotics have no eyes. They can't see what is a bacteria and what is not. They can only rely on some special components they carry to identify and contact bacteria. But.

If the bacteria cannot recognize them or come into contact with them in some way, the antibiotics will not be able to work at all - for example, vancomycin works by interacting with the precursor pentapeptide of the bacterial cell wall.

d-ala-d-ala (d-alanine-d-alanine) is combined to catch the bacteria before it can work. Once the precursor undergoes certain changes, causing vancomycin to be unable to bind to the precursor, then

Vancomycin is useless."

[Author: In reality, vrb——ycin-resistant bacteria (vancomycin-resistant bacteria) is because the structure of the precursor pentapeptide of the cell wall has changed, causing vancomycin to prevent cell wall synthesis by binding to the end of the pentapeptide.

It is almost impossible to combine with this d-alanine-d-alanine end, thus resulting in resistance to vancomycin. The current way to deal with this kind of drug-resistant bacteria is to combine dipyridyl and vancomycin.

Mycin combines to form a dipyridyl vancomycin conjugate, and the dipyridyl group can form a complex with the zinc ions in the bacteria, so that vancomycin will be linked to the bacteria by the dipyridyl group and can still be

Continue to realize the sterilization function.】

(If you want a simple explanation, vancomycin needs to be attached to bacteria to be effective, and drug-resistant bacteria cannot be attached to vancomycin due to mutations. Then the improved version of vancomycin holds a hand that can interact with bacteria.

A certain part of the universal rubber glove is strongly bonded, and then vancomycin can be successfully hung up and the drug-resistant bacteria can be killed)

"What does that mean..." Yuantai was confused.

This explanation may be able to be understood by Chiba, Conan or Fujioka Takamichi, but it is indeed too difficult for these children.

"Let me give you an example," Qianyu sighed. "For example, I am vancomycin, and then Haiyuan is——"

Qianyu's words were cut off instantly after Haiyuan Ai glanced at him.

"Well, if the police are vancomycin and ordinary bad guys are ordinary bacteria, then the police only need to find ways to find these bad guys, then catch them and put handcuffs on them, and these bad guys are finished. Can you understand this?

"

Genta, Ayumi and Mitsuhiko nodded.

"However, now there are bacteria that are resistant to vancomycin, such as Kaito Kidd." Qianyu spread his hands. "Kidd is very mobile. Even if the police encounter Kidd by chance, Kidd will not be able to survive."

If you can get rid of them through your own actions, the police will not be able to catch Kidd at all, let alone put handcuffs on Kidd."

"You mean those resistant bacteria won't be caught by vancomycin?" Mitsuhiko asked tentatively.

"That's right," Qian Yu nodded. "Do you understand this step?"

"Yeah!" Yuanta and Ayumi nodded.

"So, now, we have equipped the police with a big fishing net," Qianyu continued to explain imaginatively. "This fishing net is very big and very strong. As long as the police encounter Kaito Kidd, they can throw the fishing net out.

Once Kaitou Kidd catches him, he can no longer escape and can only be handcuffed by the police."

"I think I understand?" After about fifteen seconds, Mitsuhiko said uncertainly.

"Anyway, that's pretty much it..." Qianyu sighed. "I might go crazy if I continue to explain... If you still don't understand, come to me after takeoff tomorrow. I should be able to think of breaking it into pieces by then.

I'll explain it to you... I hope you can understand what I'm saying and you don't need me to say it again..."

"Children," at this moment, Fujioka Ryūdō, who had been looking at Haibara Ai and Qianyu, spoke up. "You should learn from these two children - and maybe you should also learn from the boy with glasses next to him who is not confused at all.

The three of them have a very rich reserve of knowledge. Geniuses like them will be very popular in the future whether they are in school or when they grow up. You must grow up to be knowledgeable people like them!"

…………

On the way out of this room, Qianyu took the initiative to find Haiyuan Ai.

"Isn't this drug resistance appearing too suddenly?" Qianyu asked with a frown. "How come a strain that is completely resistant to vancomycin suddenly appeared?"

As common biological knowledge, the emergence of drug-resistant strains comes from genetic mutations that occur all the time, and the increase in drug-resistant strains comes from the screening of drugs - if there are 100 bacteria, one of them suddenly mutates into a drug-resistant strain.

Drug-resistant strains, then only 1% of the bacteria are drug-resistant strains. But if these bacteria are now dripped with antibiotics, then except for the only drug-resistant strain, all the bacteria will die, and only the only one will be left.

A drug-resistant strain, then all bacteria will be drug-resistant strains.

In other words, if they follow the laws of nature, they should find that vancomycin has a perfect killing effect on most bacteria, but is ineffective against Gram-positive bacteria in a very small number of patients.

However, now, the vast majority of bacteria have not suffered a fatal blow, which shows that the proportion of these bacteria resistant to vancomycin may be very high.

Under natural circumstances, this is almost impossible unless...
Chapter completed!