A few days later, Chen Changan set out to return to Gusu City.

The clinical test of bionic prosthesis was very smooth. He had nothing to do if he stayed in Kuncheng again, so he naturally went back to Gusu.

The company's administrative department is also steadily advancing the participation of the Medical Expo.

If Ruikang wants to participate in the medical exhibition, he will definitely not be rejected. The organizing committee will even set up a large exhibition hall for Ruikang. After all, Ruikang, as the largest medical device profiler in China, enjoys special treatment at all.

However, this medical exhibition will be held between September 2 and 5, and it will take more than two months. After Chen Changan gave instructions on the participation of the meeting, he did not care about it for the time being.

The prosthetic body base is also carrying out the expansion of the production line in an orderly manner. Every day, new exoskeletons are transported to users. Chen Changan doesn’t have to worry too much. Li Yuntong and Yu Cheng will do the work.

After Chen Changan returned to Gusu City, he spent most of his time in the research center and conducted research on Down syndrome in the laboratory next to Yunheng's team.

He personally took charge of the project for this project. Apart from him, there were only a dozen temporary recruits of researchers and interns to help him.

Yun Heng, Wang Jia, Fu Yi and other leaders did not get involved in the topic of Down syndrome. This time, Chen Changan will independently complete all scientific research work, which is also a challenge to him!

However, even so, his scientific research is much easier than that of ordinary people, because the theoretical argumentation stage basically does not take much time, and he is very confident that the research direction of the project should be correct and there will be no effort in vain.

After all, he is moving forward on the shoulders of a giant. With the help of advanced technical knowledge in his mind, he can have certain results in many uncertain things in scientific research, which may save too much effort in scientific research.

As powerful as Edison, when he invented the light bulb, he tried it 1,600 times before he found the suitable filament material.

But Chen Changan didn't have to spend so much effort. He could directly find the right choice among the countless choices!

...........

One month later.

The treatment of Down syndrome is progressing very smoothly. Chen Changan has successfully extracted the XIST gene, which is crucial to this project, from the cells collected by volunteers!

In the laboratory, seven or eight scientific researchers wearing full sterile suits, as well as Chen Changan, were surrounded by a large microscope.

Through this electron microscope that can be magnified by three million times, even genes that are only the size of molecules can be clearly projected on the screen for everyone to appreciate carefully.

"Is this the XIST gene?" a researcher wearing goggles said with some exclamation.

Chen Changan nodded excitedly and looked at the three-dimensional image on the display screen with a little emotion.

In fact, strictly speaking, DNA is impossible to be observed by the naked eye. The reason why DNA can be "seeed" is an image obtained by using algorithms and using triangular lenses to analyze the three-dimensional structure.

"Mr. Chen, can the XIST gene be used to really suppress the excess chromosome of Down's son? It's so amazing."

Chen Changan turned his head and glanced at the person asking the question. This was an intern recruited from Sun Yat-sen University. He just graduated from a doctorate this year and has not long been entering the field of scientific research. He is a pink and tender newcomer.

"Of course it's OK. I think you may not pay much attention to cutting-edge breakthroughs in epigenetics."

"Professor Jiang Jun, a Chinese-American, once published a paper in the journal Nature. He tried to transfer the XIST gene into the excess chromosome 21."

"And it has been successful at the in vitro cellular level."

"According to his arguments and tests, we can know that after the extra copy of the **IST gene of chromosome 21 is silenced, its stem cell activity and reproduction ability is stronger, and perhaps the whole body cells will gradually be replaced by the silent cells."

"But because cells have a life cycle, when cells change, this silencing effect disappears, and the most rare thing is the change of heart and brain cells and the problem of breaking through the heart and brain barrier."

"The human body is very complex. As the most critical and important cells, how to safely transfer the XIST gene into the heart and brain cells, and make it effective and maintain stability is one of the biggest problems in front of you."

Chen Changan was not the first person to propose this treatment idea.

As early as a few years ago, scientists tried to perform this test on IPS stem cells derived from Down syndrome patients.

In addition, it was also successful in the in vitro cell experiment. After the XIST gene was artificially transferred to the extra chromosome 21 in stem cells, the "21 chromosome Pasteurite" was successfully formed, inhibiting the gene expression of the extra chromosome.

In this way, at the cellular level, the cells of patients with Down syndrome will be the same as those of normal human cells, without having one more chromosome, and the functions and morphology of the cells will also be normalized.

The cells are normal and this extra chromosome is no longer effective. In theory, the patient will gradually return to normal. Although the physical damage is obviously irreparable, the interfered intelligence has the hope to return to normal levels.

This treatment idea is very clinically meaningful, but there are still many problems to truly achieve this.

For example, how to remove all so many cells in the human body and remove one chromosome!

What means should be used to target the delivery of genetically modified genes into human cells, rather than operate in vitro.

How to control directionally, identify gene fragments that need to be closed, and not accidentally silence other normal genes.

These are the main problems that plague this technology's clinical development, and what Chen Changan needs to do is to overcome these problems one by one.

After listening to Chen Changan's explanation, several interns felt unprecedented resistance and difficulties. It was really difficult to solve these problems under the existing science.

A more bold intern simply raised her hand and asked, "Mr. Chen, I don't think it's necessary to study this technology thanklessly, right?"

"Instead of spending time studying how to restore the intellectual problems of Down's children, it is better to screen out the problematic embryos during the pregnancy test stage as soon as possible. This study may expand greater value and have more scientific research significance in genetically modified products, but for Down's syndrome, the effect is not as good as popularizing prenatal examinations."

Chen Changan shook his head and said helplessly: "The idea is beautiful, but the reality is not ideal."

"Although prenatal genetic testing is effective, it is not that effective. After all, the current prenatal examination methods are not yet able to screen patients with Down syndrome 100%.

"Some Down children have a low risk when they are in the Down screen, but they are born with Down syndrome."

"Some expectant mothers have high risk of children with sieves in their belly, but because they see many children with high risk of sieves but are still healthy when they are born, they would rather believe that the child in their belly is healthy and give birth to him/her."

"No matter how developed modern medicine is, it cannot avoid human struggles. Unless it is possible to change this situation when it can be 100% correct and without any luck."

"And, there are now hundreds of millions of Down children living around the world, and there is no trend of any decline in the birth rate of Down children every year. These children have no right to choose from since birth. How innocent are they."

"If possible, they can restore their intelligence to the level of normal people. Even if they are physically incomplete, they can at least have the right to choose instead of living a life of dementia in a daze."

"The emergence of medicine itself is to make life better. Since there are so many Down children now, we should do something for them instead of giving up on them directly."

The intern who asked the question smiled embarrassedly and explained in a panic: "Mr. Chen, I don't mean that... I didn't want to give up on them..."

Before he finished speaking, Chen Changan interrupted: "I understand that this is just a normal academic discussion, and I have no intention of accuse you."

"Okay, the question has ended here. Let's start working. Let's simulate the genetically modified cells in the external body and cheer up. If anyone makes a mistake, stay alone to work overtime at night!"
Chapter completed!