Just when the bionic prosthesis swept the front page and hot reports of major websites and TV stations around the world with its unstoppable power, Yun Heng and his team did not have the time to pay attention to all news reports from the outside world.

Because their project process is at its most critical moment.

After Chen Changan provided him with the ons-6 gene replacement technology, Yun Heng immediately began to synthesise artificial viruses and make ons vectors. After three months of hard work, a batch of artificial viruses and ons fluids used for tests were manufactured.

Everything is ready, now it's a test.

Of course, this new experimental drug cannot be directly tested with AIDS patients, and mice that have made great contributions to human medicine cannot be used as experiments.

However, through the application, Yun Heng asked several monkeys to come from the Huaxia Primate Research Center and had HIV in the monkey's body.

There is no way, AIDS can only be transmitted in primates such as monkeys and chimpanzees.

You should know that the theory that the origin of AIDS is basically accepted is that Hiv1 and Hiv2 originate from different primates, monkey HIV, respectively.

According to research surveys, Hiv1 type originates from the monkey HIV virus, a species of African chimpanzee species.

The hiv2 type originates from the monkey HIV among African white-browed monkeys.

These two viruses were introduced into the human body through various channels, and after a series of mutations in the human body, they finally adapt to the human environment and survive for a long time, becoming a virus that is rampant in humans.

The source of human AIDS was first discovered in Africa. As for the specific channels it was introduced into the human body, it is unknown.

However, the transmission of AIDS is nothing more than blood transmission, mother-to-child transmission and sexual contact transmission.

How AIDS spreads from chimpanzees to humans can only be understood.

One is said to be because African tribes have a tradition of hunting orangutans and drinking blood. Another is that European colonists brought HIV back to Europe after doing some shattered views on the African continent.

As for which of these two possibilities is correct, it is not clear, but at least one thing can be known, that is, the potential of human beings is beyond imagination.

Going back to the topic, Yun Heng asked several test monkeys from the Primate Research Center, and notified Chen Changan that he was preparing to conduct animal tests.

In fact, the experiment is not complicated.

Under the attention of Chen Changan, Yun Heng injected a tube of artificial virus using OnS fluid as a carrier and loaded with the Cas9 gene editing tool into the monkey's body. The first phase of the work was completed.

The function of this drug is to use gene editing technology, under the guidance of RNA, the 32 bases of the r5 gene are guided, which leads to the loss of bases in this gene.

This base deletion prevents the Hiv1 virus from entering the host cell.

In simple terms, the r5 gene is regarded as the entrance to HIV enters the human immune cells, and is a door. The Hiv virus uses it to enter the human immune cells.

The mutation of the gene produced by the r5 gene will cause the door to be locked and cannot be opened, thus preventing the Hiv virus from entering immune cells.

In this way, as long as the immune cells in the human body are metabolized, the hematopoietic stem cells of the r5 gene differentiate into new immune cells that can block the entry of the Hiv virus. Then the Hiv virus will no longer destroy the immune cells of the monkey and will no longer cause harm to the immune cells.

Once the Hiv virus is blocked and cannot enter the cells, these viruses will all die and be completely eliminated from the body.

All r5 genes are edited once, and all r5 genes are artificially mutated.

In fact, this treatment plan has been proposed in the academic community for more than ten or twenty years, and countless life engineering experts have tried to overcome this difficulty and fundamentally eliminate the Hiv virus.

But no one has succeeded yet. The closest example to success is the gene editing baby Lulu and Nana, a biology professor at Huaxia Southern University of Science and Technology.

r5 gene.

The advantage of doing this is that gene modification in the embryonic stage is relatively simple, because the embryonic cell tissue has not yet been differentiated, and the r5 gene is modified at one time.

The r5 gene, including future germ cells, will be a practice that seriously pollutes the human gene pool.

Moreover, there are flaws in simple gene editing technology, one of which is the off-target problem. It may cause changes in other irrelevant genes when editing genes.

In other words, a normal-born baby girl may have produced several different gene mutations in the body, and the r5 gene is edited.

The consequence of this is that the editing results of different cells in the embryo are different. The cells in the body of adult babies will have several different editing results. Some cells may have the ability to resist AIDS, while others do not.

Even the only thing that the tester could confirm was that they had gene edited the two babies. As for what was edited and what impact it would have, they didn't know.

Although the baby girl was successfully born, everything is unknown how much ability to resist AIDS and whether there are other defects in genes.

This crazy practice of using gene editing, cloned human embryos into human or animal bodies, conducting human experiments, ignoring ethical review, treating life as a joke, and ignoring the consequences of the experiment, is seriously illegal in any country in the world.

In any country, modifying human embryo genes is a matter of crossing the red line. As long as you do it and find it, your entire academic career will be ruined!

Yunheng's solution is different, because with the help of Ons-6 gene replacement technology, after some in vitro cell tests, it can be confirmed that CRISPR technology combined with gene replacement technology will not have off-target problems, and can accurately edit cells that need to be edited without any mistakes.

The r5 gene and the r5 gene will not be changed.

If you do this, the r5 gene effectively blocks the invasion of the Hiv virus, and the Hiv virus will only invade the human immune cells.

However, there is no change in the DNA of the human body's somatic cells and germ cells. This artificial gene mutation will not affect the germ cells and will not pollute the human gene pool.

All changes will only affect a single patient, greatly reducing the risk of gene modification, improving safety, and curing the disease with great peace of mind without worrying about any ethical problems.

This is also why Chen Changan believes that ons-6 gene replacement technology combined with CRISPR technology can truly open the Pandora's box of human gene editing.

Humans will truly have the ability to modify and change the genes of body cells at will, and even specify the genes of a certain cell. As long as the absolute purity of the germ cells can be guaranteed, this gene editing will not even be passed on to the next generation.

This is a very terrible thing. Once it is made public, the reaction will be even more sensational than the products such as ten bionic prosthetics.

If there was only a single CRISPR technology in the past, it was like a good friend who had a handy pot, but there was no good rice and could not cook a pot of sweet white rice.

Then the ons-6 gene replacement technology is the bag of fragrant rice!

Chen Changan must have to cover this technology tightly. Once it is made public, it may affect the development of the entire human society in the next thousand years. We must be cautious and cautious.
Chapter completed!