Wen Ru is posting a notice about streaking in the hospital's WeChat group. The official time is tomorrow at three o'clock in the afternoon. At that time, he will streak around the hospital three times to fulfill his bet. This streaking is truly true.
Buttoned.
The whole hospital was excited about it. Everyone thought that Dr. Wen was a man who truly kept his promise. If everyone could do what Dr. Wen did, the world would be full of integrity.
There was a lot of discussion in the hospital's WeChat group. Whether they were men or women, they couldn't wait to see Dr. Wen run naked. What they saw was his courage and his magnanimous gentlemanly spirit. There was a burst of fireworks in the group.
, if Director Zhao hadn’t blocked everyone’s discussion in time, the whole group would have been a streaking discussion.
Yang Ping was not interested in his streaking news at all. This man had a weird temper. He could do whatever he wanted. Nothing would happen if he streaked. But if he was forcefully stopped from streaking, something might happen. Yang Ping was very busy. He had to rush to Nandu.
The Medical University participated in the review of Guan Ruyan's scientific research project. The funding for this project is 50 million. This level of single-project funding is considered a large project in a university.
For key projects, Nandu Medical University is very strict, so it invites a group of top scholars inside and outside the school for careful review. Yang Ping is invited as a scholar within the school, because Yang Ping is currently an outstanding young person and a candidate for academician.
And he is also preparing to win the Nobel Prize.
Guan Ruyan has also encountered some trouble recently. His son won the championship in the National Youth Science and Technology Competition, which was originally a good thing. However, a reporter who was short-sighted went to the school to interview and caused a lot of trouble.
The principal and teachers of Guan Ruyan’s son’s school did not notify Guan Ruyan about this interview. Maybe it was because time was too tight, or maybe because the reporter didn’t say at the time that he wanted to interview the child himself, so Guan Ruyan was not notified about this anyway.
After the reporter arrived at the school, the principal and teachers of the school were very happy and attached great importance to the interview, because it could play a certain publicity role for the school. After interviewing the principal and teachers, the reporter temporarily asked if he could meet this outstanding child.
, the teacher said yes, since it was an interview, what was wrong with meeting the children in person.
Under the arrangement of the principal, the reporter met this child. Unexpectedly, the reporter had a bachelor's degree in biology and was considered a semi-professional on this subject. After meeting the child, he casually chatted with the child and was surprised. The child was very interested in his own life.
He could memorize the paper proficiently and knew some of the concepts in it, but it was obvious that he had memorized it, because when asked carefully, the child knew nothing about it. Then the child was very honest and said that his father wrote the paper and told him to memorize it.
, he did not participate in the experiment, but he went to the laboratory several times and took many photos.
This matter was written into an article by a reporter and published on the Internet, and it immediately exploded. How did the promised youth science and technology competition turn into a competition between parents behind the scenes? Is this competition still meaningful? Of course, it is the capital for future studies.
The competition is no longer a simple competition.
This incident had a huge impact, because the identity of the child's parents was finally discovered. Both parents were professors at a medical university, and the son was a primary school student. He took a medical paper to participate in the competition. If you think about it, you will know what happened. In fact, some people questioned it at the time, but
The organizer announced that after investigation, it was confirmed that the doubts were rumors. The contestants' experiments and papers were completed independently without any fraud, and the doubts were dismissed.
Everyone can't help but lament that someone else's child is still smart, and his own child can't even understand a homework, but someone else's child has been able to publish papers in internationally renowned medical journals and can conduct sophisticated experiments. Alas, the gap is really too big.
Yang Ping came to the conference room of Nandu Medical University. There were still a few minutes until the meeting started. The review experts and professors were almost here. Guan Ruyan had already arrived in advance. Sitting next to Guan Ruyan was his assistant Lu Xiaolu.
Guan Ruyan's face was obviously haggard. It was obvious that he had been troubled by his children's affairs recently. Now there are loud calls on the Internet to investigate this matter and to cancel his children's championship.
"Professor Yang!" Guan Ruyan greeted Yang Ping.
When they heard that Yang Ping had arrived, many professors in the conference room stood up to express their welcome. Yang Ping smiled and bowed to everyone in return, and then sat down in his seat.
Several professors who came later also arrived one after another. Finally, President Rao and Academician Xiang entered the conference room together, and everyone stood up to welcome them.
Guan Ruyan's topic is about CAR T cell therapy. Americans are currently leading the way in this area. Guan Ruyan wants to use this topic to catch up with American cell therapy technology. Yang Ping looked at the outline of the topic and found that indeed, the idea is relatively novel.
If we can really succeed, we can significantly shorten the gap with them.
Not long ago, Yang Ping used cell therapy to treat a tumor patient and achieved great success.
But Yang Ping's main energy was not here, and it was impossible to study everything, so he communicated some results of cell therapy with Lu Xiaolu. Lu Xiaolu was very smart. He not only understood the meaning of this topic, but was also able to conduct some research along the lines of thought.
When communicating with Lu Xiaolu before, Yang Ping felt that his research in this field was very deep. In this topic, almost all the new ideas proposed by Lu Xiaolu at that time could be seen. So, are these ideas Lu Xiaolu's or Guan Ruyan's?
Well, this made Yang Ping a little confused.
The meeting started on time. There were all big people present, some were invited by friendly schools, some were from our own school, and there were two international friends, so the meeting was quite formal. Although there was a human element, it was not much.
"Let me introduce the basic situation of this topic first---" Guan Ruyan knew the importance of this meeting, and it would obviously be a lack of respect to let his assistant introduce it, so he went into the battle in person, and needed Lu Xiaolu's help when necessary.
This chapter is not over yet, please click on the next page to continue reading! Because this project was completely designed by Lu Xiaolu, the idea is his, the details are also his, and he also wrote the final project plan. Guan Ruyan is very busy recently and has a lot of academic work
He has to attend the meeting and deal with his son's affairs, so he has only recently become familiar with this topic. It is inevitable that the experts attending the meeting will be ruthless and serious, so Lu Xiaolu can help deal with it at critical moments.
"The T cells isolated from white blood cells are added with specific chimeric antigen receptor genes, modified into the CAR T cells we want, and then placed in the laboratory to grow and multiply, waiting for them to be transformed into cells that can recognize
And destroy the warriors of cancer cells. At this time, we inject them into the blood of the human body and reach the target tumor through blood transportation. These special warrior cells recognize and kill tumor cells. This is the common practice of CAR T cell treatment of tumors in the world.
"
"CAR-T therapy, as a revolutionary tumor treatment method that uses genetic engineering technology to transform the body's own immune cells, has brought new hope to countless patients with blood cancers, but there are currently unavoidable problems---using CAR
-T cells cannot treat solid tumors because solid tumors lack binding antigens related to blood tumors, which makes CAR-T unable to recognize and locate solid tumor cells."
''Our project is to solve this problem---using a special kind of CAR-T cells to treat solid tumors. If successful, this will be a huge breakthrough."
After Guan Ruyan briefly introduced the topic, the audience burst into warm applause. I have to admit that this topic has captured the biggest pain point of CAR-T therapy. Currently, many pharmaceutical companies promoting CAR-T therapy are investing heavily in research on this topic.
Pain points, but there is no obvious breakthrough for the time being, and Guan Ruyan’s project solves the pain points of CAR-T therapy from a new perspective. If successful, it can expand the indications of CAR-T therapy, which is a great benefit for both patients and pharmaceutical companies.
Good news.
"Professor Guan, if you use CAR-T therapy to treat solid tumors, can you disclose the specific implementation method? We know that because CAR-T cells are currently limited to blood cancer treatment, because most solid tumors lack the ability to interact with CAR-T cells.
Antigens bound to cells, so they cannot be recognized and eliminated."
"Although neoantigens, a class of HLA-binding peptides resulting from tumor-specific mutations, are highly immunogenic, they can bypass central thymic tolerance and can be avoided because they are not present in normal tissue.
Common issues with selecting antigen targets for CAR-T cell therapy, but they are not applicable to large numbers of patients.
"In addition, even after the optimal antigen target is selected, the function of CAR-T depends on factors such as the ability to prevent tumors from escaping immunogenic epitopes. That is, there is still the possibility of tumor escape, and these factors are all
This results in the therapy being less effective in solid tumors."
"Do you think that when CAR-T cells are combined with targeted drugs, CAR-T cells express a special cell surface protein for drug-resistant persistent cells, which can more effectively delay the emergence of complete drug resistance---"
The expert who asked a series of questions was Professor Shen Xuebin from the imperial capital. Professor Shen is a professor who has returned from studying abroad. He is a talent introduced by the Thousand Talents Program. He is very optimistic about this project and has admired Guan Ruyan's talent for a long time. This time he just took this opportunity to meet with Guan Ruyan.
Communicate face to face.
"Our idea is to modify the neoantigens into antigens that can appear widely in certain solid tumors, so that the scope of application can be expanded." Guan Ruyan replied with a smile, and then took a sip of water.
"I mean how do you achieve modification and what modification tools do you use? I don't think there is a way to do it with the currently known antigen modification tools. What unique insights do you have on the application of modification tools? Secondly, how to avoid the possibility of modification with new tools?
Controllability, so that it does not produce some negative reactions that are out of control, because almost all new tools face the problem of out of control."
Indeed, Guan Ruyan did not study deeply on the issue of retouching tools. Lu Xiaolu had always been in charge, so he took another sip of water and cleared his throat: "I'm sorry, I'm sorry, I've had a cold these past two days and my throat isn't very good, Xiaolu, Please introduce the details of the modification tools to everyone."
In fact, few people are so serious about this kind of meeting. It is obviously inappropriate to hold on to these details and insist on asking the truth. We are all friends in the same circle, and we have to be merciful and merciful. Next time it is our turn, What should I do if others ask sharp questions like this? However, Professor Shen is an upright person. He is very interested in this topic and has many questions in his mind. Today is a rare opportunity for face-to-face communication. Naturally, he has to clarify the questions. He did not let Guan Ruyan know at all. Embarrassing meaning.
Lu Xiaolu immediately took over: "Professor Shen asked very well. Our modification tool is a brand-new modification tool. This tool is tailor-made for this project, ---"
Next, Lu Xiaolu answered Professor Shen's question in detail. Professor Shen nodded, very satisfied. His guess was indeed correct. The other party used a brand-new modification tool, but the idea of the tool surprised him. Why hadn't he thought of it before?
"You had a professor at Heidelberg University in Germany who proposed this idea before, but it never came to fruition, right?" Professor Shen has a wide range of knowledge.
Lu Xiaolu immediately said: "That's my doctoral supervisor. I continued to research along his ideas. Oh, Professor Guan led me to continue to research along his ideas, and finally succeeded this year, so we started the current project. .”
Lu Xiaolu found that he almost crossed the line, so he handed the initiative to Guan Ruyan: "If Professor Guan hadn't been in poor health today, it would have been more profound for him to explain the modification tools. My understanding of the tools is far inferior to Professor Guan."
This chapter is not finished yet, please click on the next page to continue reading the exciting content! Guan Ruyan is very satisfied with Lu Xiaolu’s performance. This guy is very smart and can always provide him with divine assists. Then Guan Ruyan added some gorgeous words, which is right Summary of Lu Xiaolu’s speech.
"Professor Guan, my stomach feels a little uncomfortable. I need to go out for a while, at most ten minutes." Lu Xiaolu suddenly felt unwell and asked Guan Ruyan for a temporary "leave".
Guan Ruyan immediately nodded in agreement. This kind of thing is not allowed but must be allowed. It is impossible for him to pull his crotch.
"Your new modification tool is very clever. I am very curious about how the modified antigen can achieve persistence at the binding point. It is said that neoantigens of your type have a common feature, which is the lack of persistence in binding. Regarding sex, I don’t know how Professor Guan solved it.”
Another professor invited from the United States was interested in another question and asked the question in English.
"We discovered a new expressed protein in our previous research, which contributes to the persistence of binding, so this time we will simulate the mechanism of tumor cells releasing expressed proteins, in new CAR-T cells with new When the antigen binds, let it release this expressed protein, so that the binding becomes durable."
"We have also studied this expression protein, but it is not widespread. It is easy to fail to express in many scenarios. How do you solve the problem of expression failure, that is, how do they achieve accurate and precise identification of expression scenarios and timings?
Sensitivity, how to achieve the complete expression of expression after it is started."
I'm afraid this issue is very complicated to talk about, and Guan Ruyan didn't have time to figure it out at the time, because this issue is not a window paper issue, but involves the cross-application of many current cutting-edge technologies.
"This issue is very complex and involves the cross-application of many cutting-edge technologies. If it takes a lot of time to talk about it, is that okay? I will explain it to you in detail after the meeting." Guan Ruyan looked around him out of the corner of his eye and saw why Lu Xiaolu hadn't come back yet.
