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0357 Chapter big topic

 The regional competition of the Golden Knife Award is proceeding in an orderly manner, the competition is becoming more and more fierce, and the harsh scoring makes it increasingly difficult to obtain full marks.

Yan Jiejun from Appendix 2 and Su Fengyu from Appendix 1 fell out of the perfect score camp during the third batch of surgeries. They made the same mistake.

During an operation for a comminuted fracture of the lower end of the humerus, a young female patient chose the wrong suture for cosmetic incision suture and was deducted points.

In fact, joints used to be a contraindication for cosmetic sutures. The advantage of cosmetic sutures is that there are fewer scars, but the disadvantage is that they are not as strong as conventional interrupted sutures.

Joint surgery requires early rehabilitation training after surgery. Rehabilitation training is usually started on the second day after surgery, so as to obtain satisfactory joint function.

The firmness of cosmetic sutures is poor and cannot meet the needs of early rehabilitation training. It is easy to cause incision dehiscence during activities.

Nowadays, cosmetic suturing technology is getting better and better. If each needle can hook enough dermal tissue, it can be firm at an early stage, and the original contraindications will become indications.

Yan Jiejun and Su Fengyu had no problem with their cosmetic suturing techniques. Unfortunately, their mastery of surgical suturing techniques was not comprehensive enough, and their understanding of various sutures was insufficient, so they made mistakes when selecting sutures.

For cosmetic sutures, they chose absorbable sutures. In fact, this is a mistake that most surgeons easily make.

Many doctors even call absorbable threads cosmetic threads, which is completely wrong.

At present, the sutures used for cosmetic sutures must be non-absorbable slip threads, such as thin nylon threads with needles, which need to be removed after surgery.

Although absorbable sutures do not need to be removed, they are used for skin suturing. During the absorption process, foreign body reactions and inflammatory reactions will occur, resulting in more obvious scars, which is contrary to the purpose of beauty. Thin nylon sutures do not have this problem. After a few days,

, or it will be demolished after more than ten days.

If you perform surgery in normal times, this is not a problem, but in competitions, you must strive for excellence.

After the third batch of surgeries, those who still maintained perfect scores were Song Zimo, Su Nanchen, Lin Hao, Chen Ge, and Cao Qian.

The strength of the teams from other provinces in South China still lags behind that of Nandu Province, and there is no perfect-scoring team.

Lin Hao now has a sense of urgency. After three rounds of surgeries, Yang Ping's team has not been thrown away. They are still firmly tied with him for first place in the South China Division.

Yang Ping knew very well about Song Zimo's level. With this help, he would have no rivals in the regional competition, and he could sweep the country for him in the national competition.

Unfortunately, the surgeon must perform more than half of the operations in the national competition, and the surgery in the finals must be performed by the surgeon himself.

So Yang Ping is not in a hurry now. As long as he is not behind in points, he has no plans to step forward for the time being. He will seize the time to do more important things.

The project plan for the research on growing human muscles in stem cell laboratories has been written.

I have been spending all my time here these days, with more than a hundred pages of project plans sitting on my desk, making my head feel swollen after looking at it.

But there is no way, this big topic involves too many aspects.

Just like building a car, it requires the cooperation of many factories. It is impossible for one factory to manufacture all the parts.

Yang Ping wants to focus on core technology. Although he plans to cooperate with Takahashi, he has no hope for the Japanese. It is just a branch alternative.

Yang Ping's main plan has taken shape, and he needs to find several domestic partners.

The genetic laboratory of Nandu Medical University is the one he plans to cooperate with to obtain or synthesize induced proteins.

In the topic of using stem cells to cultivate muscle cells, several core technologies have emerged, two of which have emerged, induced differentiation technology and micro-scaffold technology. The third core technology in the future is cell structure stabilization technology.

Yang Ping searched for micro-stent technology for a long time and finally found a new company in Pengcheng called Rubik's Cube New Materials Company. Its 3D printing technology can achieve 15 micron printing. Although it is not enough, it is very promising.

This is a company founded by a group of returned doctors. I don’t know whether this team has the ability to complete the research and development of micro-stent. This is the only hope for domestic companies.

Only by finding these two partners can the project be completed, and Yang Ping plans to take the time to negotiate one by one.

If the University of Tokyo can cooperate with me and share technology, I can digest and absorb their technology and then improve it, which will shorten a lot of time.

But there is little hope for this. Yang Ping is not a person with illusions.

Therefore, in the main plot plan, I can only gnaw this bone from scratch.

Overtaking in corners has never happened. Technology can only be achieved step by step. To surpass others, you can only rely on speed.

Funding for scientific research is also a big problem. The first phase of funding requires about 30 million.

This investment is huge. Depending on the scientific research fund applied for, even if it is successful, the maximum cost will be one million.

One million dollars is a drop in the bucket. If you include the subsequent investment in this project, it will be worth several billions.

If there is not enough funds, it will be difficult to operate the project. These are very real problems. He now feels that Xiao Su's words are very correct.

If one day, I can freely withdraw tens of billions of funds, I won’t have to worry about this little money.

Someone knocked on the door. It should be Song Zimo who had finished the operation.

"Originally I asked you to write it, but you are going to have competition surgery. I have already finished it. This is the project plan I wrote." Yang Ping pointed to a thick stack of documents on his desk.

Song Zimo browsed the summary: "Why didn't you write about this research grant?"

"It's not that I don't want to write, it's just that I can't write for the time being. One issue requires 30 million." Yang Ping said with a smile.

Song Zimo took a breath of cold air: "One phase costs tens of millions. This is a big project worth hundreds of millions of yuan. Are we a bit ---"

Yang Ping waved his hand: "Just do this project, I will raise the money."

Yang Ping felt that it was time to start and could not delay it any longer.

Start now, and wait until you win the Golden Knife Award and receive the award from the System Space Laboratory. By then, work on this topic will have already begun, and you can start working on it yourself.

Now Yang Ping feels that if he really wants to do something, it will be completely impossible without money.

Huawei spends tens of billions of R&D funds every year, and it lasts for more than ten years before the Kirin chip is released.

No other company has such courage and foresight, and this is an investment with no end in sight.

Compared with this kind of arduous technological research and development, building a few houses can make a lot of money. Everyone likes the latter, making money quickly and happily.

Duke University and the University of Tokyo have invested millions of dollars in this project, and this is all in the early stage. They plan to continue to invest hundreds of millions of dollars in research and development funds in this project.

"All kinds of scientific research funds, if you can get one million, they will be maxed out. For the hospital's money and the Overseas Chinese Foundation, even if Director Han and Dean Xia agree, it will be useless. The money belongs to the hospital, not to individuals. If you spend a few thousand

It's impossible for me to do scientific research for you." Song Zimo was very worried.

Tens of millions is not a small amount. If you are running a business, you may also be able to attract venture capital. Who is willing to do this kind of scientific research and lose money?

"I'll figure out the money thing." When Yang Ping had an idea, he already thought of the difficulties.

"Thirty million, some great professors may not receive even thirty million in scientific research funding in their lifetime." Song Zimo felt that the money was too much.

"You can perform the competition surgery with peace of mind. I will take care of this matter. The project must be done." Yang Ping left no room for doubt.

"Okay, no matter what, I support you. No matter how much money you have, there is a limit. Let's find a solution together." Song Zimo fully supported Yang Ping.

He is going to organize everyone to review today's surgery and tell Yang Ping to think of ways to raise money together when they have time.

In the mobile WeChat group, the results of Wei Danian’s genetic sequencing finally came out.

Some congenital diseases were all excluded, including glucose 6-phosphatase deficiency, pyruvate dehydrogenase and carboxylase deficiency, fructose 1,6 bisphosphatase deficiency, and oxidative phosphorylation deficiency, which are known congenital diseases that cause lactic acidosis.

Diseases do not exist in Wei Danian.

Even after using the most advanced genetic testing technology in the country, it was still in vain.

Dr. Wen Yulin's gene sequencing report was written for dozens of pages, and she gave a detailed report on the sequencing methods, equipment used, and sequencing results.

Dr. Wen asked whether we should continue to expand sequencing, analyze some precursor molecules and metabolites, and even resequence genes. This is a huge project.

Even the genetic sequencing failed to find the problem, is there any need to continue?

Such rare cases are the most precious resources. Wouldn't it be a pity if we gave them up like this?

However, Nandu Medical University’s genetic experiment cannot focus all its efforts on genetic testing of Wei Danian. There are still many issues to be done.

If it weren't for Su Nanchen's face, how could he accept such a favor task?

Yang Ping suddenly remembered that his system recently had a case push function, and comprehensive medical activities could be carried out for the pushed cases.

He entered the system space and used the case push function to constantly change keywords and narrow the scope of push. Finally, through accurate push, he obtained a case that was very similar to Wei Danian.

Yang Ping conducted the most extensive inspection of this experimental subject, including inspections of various laboratories and equipment.

But no clues were found, so they tried to perfect the patient's genetic sequencing.

Real-life examination methods are available in the system space, and there is no need to queue up for examinations in the system space. The resources are all around the cases.

Something magical happened. A few hours later, the fourth-generation gene sequencing technology was completed, and a dozens-page gene sequencing report came out.

After reading the genetic test report, the cause was still not found.

Yang Ping went through several more gene sequencing tests. This time, the huge examination cost him tens of thousands of points.

However, compared to simulated surgery, the consumption of these points is still bearable.

Finally, a report showed that there is a mutation in the ATP5F1D gene, and this gene is involved in the function of mitochondria. It is the mutation of this gene that causes problems in the metabolism of pyruvate, resulting in the accumulation of lactic acid.

"Can we continue testing and use fourth-generation gene sequencing technology to focus on testing the ATP5F1D gene? If we do it a few more times, there may be mutations in the gene."

Yang Ping left a message in the group.

"I'm very sorry, the fourth-generation sequencing equipment is currently unavailable." Dr. Wen said it was a pity that he was very busy with the project recently.

Ten minutes later, Dr. Wen made an OK gesture.

"If we conduct comprehensive sequencing again, we simply cannot free up resources. We can only conduct accurate testing of the ATP5F1D gene, which can be arranged."

If you go through every household in the entire city and search for a lost treasure, you can imagine how difficult it would be.

Now it is much easier to search only one house.

This is the first time Yang Ping has used this case push function. I wonder if the examination conducted in the system space has any guiding significance in reality.

"We use fourth-generation gene sequencing technology and can produce results in a few hours. We will start doing it tomorrow." Dr. Wen added.

In fact, Su Nanchen saw the conversation in the group and called Lin Lan, who was willing to continue to help with testing.

Lin Lan is the director of the genetic laboratory of Nandu Medical University, a doctoral supervisor, and also has another identity: Su Nanchen's future wife.

Lin Lan made the arrangements herself, and Wen Yulin will definitely comply. Lin Lan is her doctoral supervisor.


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