The study room of Academician Xiang Lao of Nandu Medical University.
Old bookshelves circle the room, and they are all filled with medical monographs.
On the old academician's desk, on the right is Yang Ping's project plan and experimental instructions on stem cell cultured muscle. On the left is a pile of thick monographs, and he keeps pulling out new monographs from the bookshelf to read.
After flipping through a pile of monographs, the old academician started to use the computer to check papers again. He has been in the study for almost eight hours today. Even breakfast and lunch were brought in by his wife. This has been like this for the past few days, and his wife can't help but feel a little worried.
"You should move a little, otherwise you may easily get venous thrombosis in your lower limbs." My wife couldn't help it anymore and reminded her gently at the door.
Normally, the wife would not bother the old gentleman while he was reading. For a man in his nineties to sit like this for several days in a row, he was really worried about venous thrombosis.
But the old academician didn't hear his wife's reminder at all and continued to read the papers and take notes from time to time.
He was in a state of excitement and completely forgot how long he had been sitting.
"Whose project plan is this? How many days have you been reading it? Today I sat down from early in the morning for eight or nine hours in a row. If it doesn't work, I have to move around."
For the sake of the old man's health, my wife had no choice but to use force and took the pencil from Academician Xiang's hand, and then reached out to make a gesture to turn off the computer.
"Oh, it's eight hours again? I forgot, yes, walk around." The old academician spotted the angry madam and smiled with her face. Under the coercion of the madam, he finally stopped what he was doing, got up and trotted around the room.
"Whose project plan is this? How many days have you been reading it?"
My wife is very curious.
When Academician Xiang heard his wife mention this project plan, he stopped jogging and became energetic: "This is a project plan from a young man from Sanbo Hospital. This young man is amazing. I studied his project plan for several days. It's really rare."
of genius.”
"Is that the young surgeon that Xiao He often told you about?" The old academician's wife also knew about this. Every time Professor He came home to visit his mentor, she mentioned this person.
The old lady will naturally remember Yang Ping after mentioning it many times.
It doesn’t matter if one result is surprising, but now Yang Ping has many achievements that surprise the old academician.
The data that Yang Ping gave to Professor He were extremely precious anatomy data. At that time, the old academician did not pay much attention to them. Later, he studied them one by one carefully. Each item can be regarded as a heavyweight scientific research achievement. Yang Ping not only gave Professor He the data
, and also provides many methods, which are all brand new and state-of-the-art.
Especially the recent topic of stem cell cultivation of muscles has made Academician Xiang extremely impressed.
As for the field of stem cells, Academician Xiang is not very familiar with it, but in terms of anatomy, he is an academician and has devoted his whole life to studying this.
At that time, when he saw the plan mentioning the analysis of the subtle anatomy of muscles, the old academician's heart skipped a beat. He had always wanted to propose this concept, but felt it was immature and did not speak out for the time being. Unexpectedly, this young man not only proposed this new concept, but also
And put it into action.
At that time, when he saw the concept of microanatomy, Academician Xiang was very curious about how young people could achieve this goal. It usually takes a few years to come up with a new concept and then realize it.
After reading the project plan, Academician Xiang clapped his hands on the table with joy. As soon as the new concept was proposed, the supporting theory immediately caught up with it. This is such a rapid pace of scientific research.
Academician Xiang studied for several days and concluded that these experimental theories and methods are very mature and are not just hot-headed creation behind closed doors.
Starting from the cellular level to construct a detailed anatomy requires a lot of courage and patience.
For single-layer cell sections, in each section, there are many unqualified cells, that is, cells that have been cut off. These cells must be judged by combining several sections before they can finally be restored.
For qualified cells, it is necessary to determine what cells they are and how they are distributed.
Although artificial intelligence can now be used to replicate recognition, it is also very difficult to develop a recognition engine.
So, this is such a complex project.
But young people not only started the project, but also came up with effective methods. They have already taken the first step and are moving forward step by step.
"I won't be back for dinner tonight." After answering the phone, the old academician reported to his wife.
Madam was once again surprised. The old man had rarely eaten out for decades. Why was he having a social gathering when he was eating out today?
"Today Xiao Yang is coming to the Digital Medicine Laboratory of Nandu Medical University. I said hello to Xiao He, and when Xiao Yang arrived, he notified me that we would have a meal together and meet each other in the evening. I have always wanted to meet this young man." said the old academician.
It turned out that I was going to have dinner with Professor He and Yang Ping in the evening.
"This Xiao Yang, you haven't met him yet? Then you recommended him to Principal Rao? At that time, you made great efforts to promote him to associate professor?" The old lady thought they were familiar with each other, but they had never met in person.
The old academician was a little unhappy with his wife's questioning: "He made an exception and promoted associate professor. I not only recommended it in front of President Rao, but also personally lobbied the review committee members. That was because his academic performance qualified him to become an associate professor. It didn't matter whether I met him or not.
.”
"Okay, let's see how anxious you are. Can I just say casually that you have better eyesight? Come back early after dinner."
The old lady warned with a smile.
At this time, the old academician's phone rang. It was Professor He. When the old academician heard it, he knew that Xiao Yang was almost here.
"I have to go and wait in advance. Young people are pressed for time, unlike us old men who are free."
The old academician looked excited and hurriedly prepared to go out.
---
Nandu Medical University Digital Medicine Laboratory, Professor He’s office.
Academician Xiang and Professor He were drinking tea and chatting.
In order not to interfere with the work of young people, Academician Xiang only occasionally comes to the laboratory to ask about the progress of research.
I came to the laboratory today just to meet Yang Ping.
"Teacher, you... Xiao Yang has wanted to visit you for a long time, but he is afraid of disturbing your peace. If you want to see him, just say a word to me and I will take him to visit you." Professor He did not expect that the teacher would come in person.
I feel so embarrassed to come to the laboratory and wait for Yang Ping.
Academician Xiang chuckled and waved his hand: "It doesn't matter, I, the old man, have free time, you young people are busy, anyway, I also want to come over and see the progress of your fine muscle anatomy."
"We have begun to try to slice the muscles of cadaver specimens, and then check whether the slices are qualified. If the pass rate reaches the standard, we will start large-scale slicing. The artificial intelligence cooperation with BD Company has begun. We will introduce artificial intelligence to slice species.
The cells make the judgment, and the digital engine is still under development, so that in the future, for similar projects, we will not have to rely on manpower, but will use artificial intelligence to judge." Professor He reported on the progress of the project, which has just begun.
Academician Xiang gave some suggestions: "Due to the irregular arrangement of cells, it is impossible to achieve a true single-layer cell section, but it is possible to achieve many complete single-layer cells in each layer. Those damaged cells,
We have to rely on combining multiple slices to restore them, which is a technical difficulty, but the solution has been proposed in the experimental guide."
"Yes, Professor Yang has already proposed a solution to learn how to superimpose these slices individually to restore the shape of the damaged cells."
Professor He has read the experimental instructions countless times, and every time he reads them, it is unbelievable. It seems that Yang Ping has already considered all the difficulties he can think of and proposed solutions.
There are only a handful of digital teams in the country, and in terms of experience, our team is definitely the richest.
When it comes to micron-level human tissue sections and how to achieve single-layer cell level, logically no one can surpass Professor He. The digital human they made at that time was among the best in the world.
However, the method in the experimental guidance in front of me is obviously much more advanced than my own method, and it is easier to obtain qualified slices. Moreover, the method of using slices to construct three-dimensional digital muscles, the method in the experimental guidance is still more advanced than my own.
Where did these methods come from?
If he was learning from others, it is impossible for Professor He not to know that such an advanced method exists.
There is only one possibility. Professor Yang came up with it himself?
If you can figure it out yourself, this talent is a bit scary.
While Professor He was thinking, Academician Xiang slowly said:
"He is able to extract theories from limited experience and then apply them. This is a very remarkable induction and deduction ability. So you are lucky to cooperate with him. No matter whether the project can be successful or not, you can
Learning how to construct the subtle anatomy of the entire human body will push digital humans to a new realm."
Ever since Professor He talked about Yang Ping, Mr. Xiang was very curious, so he carefully studied the data and methods provided by Yang Ping and found that it was very complicated. The data and methods given were extremely advanced.
It is impossible for Yang Ping to have so much time to engage in anatomy research, so Academician Xiang believes that this young man's ability to summarize is amazing.
So Academician Xiang began to pay attention to this young man, and then read his spinal external fixator project and the latest stem cell project book. The old academician was extremely excited and discovered with his keen academic vision that this young man was a scientific research genius.
Not only are they strong in surgical skills, but they are also so powerful in scientific research. This is truly a rare talent.
So I was eager to see Yang Ping, so I received a call from Professor He and hurried over.
"Why did he put the research on the repair of peripheral nerve damage into this topic? It should have little to do with this topic?" Since the teacher likes to discuss this topic, Professor He followed up.
"I also thought about it for a long time before I figured it out. He looks at this problem from several majors, so he has a higher vision than us. His ideas are very clear. To clone an organ, whether it is directional cultivation or 3D printing, the prerequisites are
Understand the subtle anatomy of the organ, otherwise no method will be successful. Secondly, if you find that the organ is really cloned, he also knows where the biggest obstacle is in its application? He will study this issue together in advance, so this
The subject is huge.”
Academician Xiang sees things better than others. He can see many deep things in this project plan and experimental guidance.
"Are you saying that he listed nerves as a separate research project to prepare for future transplants?" After the teacher reminded him, Professor He probably knew the purpose.
"That's right, no matter which method is used, if the muscles are copied by us, the biggest problem faced when transplanted into the human body is the problem of nerve connection. The problem of blood vessels is easy to solve. Once the anastomosis is completed, blood can flow through. The nerves are different
, it is connected, not anastomosed at the fracture, but grows from the proximal end to the distal end, so the nerves must be studied more thoroughly. If you cannot get innervation to your muscles, it is meaningless." Academician Xiang said about Yang Ping's topic.
The layout has been thoroughly researched.
"So that's it. He wants to complete all the steps at once. From this point of view, this subject is indeed a bit grand." Professor He felt a sense of awe towards this subject.
"He proposed two solutions. One is that when cloning muscles in the future, instead of copying the complete nerve at the original location of the nerve, the nerve sheath is copied, and a layer of substance that induces nerve growth is placed inside the sheath.
After the muscle is transplanted, the nerve sheath is connected to the nerves of the human body. Under the guidance of the inducing substance, the nerves grow along the sheath and all the way to the end."
Professor He finally caught up with the teacher: "He bypassed the difficulty of nerve repair and found another way?"
"Not only did he open up another road, he opened up a second road!" The old academician said unhurriedly.
He wanted to teach his doctor well today.
"Is there another way of thinking?" Professor He was puzzled because it was not mentioned.
The old academician was quite proud: "That's because you are not responsible for this project, so you didn't mention it in the plan here. If I'm not wrong, the person responsible for the research and development of biological 3D printing technology must be doing research on tissue damage biological connection technology.
"
"Bioconnection technology?"
Professor He was even more confused.
"This is the second one, which is to use stem cells to cultivate cells in each layer of nerves, and then use microscopic 3D printing technology to connect the original cells of the nerves. However, this requires the microscopic printing of 3D printing technology to be very good. If you don't believe me, wait and ask.
, he will definitely have this project." The old academician became more and more excited as he talked, and he was proud of his guess.
Nerves cannot be repaired after being broken because they do not heal. If it can be repaired at the cellular level and restored, this is naturally a better method, but it is much more difficult than the previous idea.
Professor He was very ashamed: "Why didn't I see so many things?"
Academician Xiang sighed: "That's because you are limited to your own major and focus entirely on anatomy research. But I have had time over the years and have read many books in other majors, so I have a broader mind."
"Why hasn't Xiao Yang arrived yet?" The old academician was a little anxious.
Professor He said: "There is a bit of a traffic jam."
