"The development of digital humans will inevitably lead to the development of subtle anatomy and functional humans. The two are related. Without subtle anatomy, functional humans cannot be realized. To achieve the goal of digital cells, a digital cell must have the ability to simulate
In terms of structure and function, it is necessary to realize the connection between cells forming tissues and tissues forming organs, so that true digital human functions can be gradually realized." Yang Ping expressed his thoughts.
This is a summary of the extensive anatomical research he has completed in system space.
"You're right. I once attended an academic conference, and an American team was studying digital livers. They wanted to successfully simulate the anatomy and function of the liver, and they succeeded in doing so. So they used this liver to make a model of drug-induced hepatitis, and began to make decisions.
It was quite realistic, but then the data gradually became distorted, and finally the model collapsed." The senior academician of the project has a deep memory of this incident.
"Now that I think about it, they did not reach the cellular level in structure, nor did they establish internal logical connections at the three levels of cells, tissues, and organs. They only developed digital functional modules with functional goals in mind, so this kind of simulation is superficial.
It cannot stand the test." Academician Xiang continued.
Yang Ping thought for a while and said: "I went to Japan last year. The digital people being studied by the University of Tokyo have achieved the goal of functional people, but like the Americans, they are taking the route of embedding functional modules. They use this method
Applying it to the extreme, hundreds of thousands of functional modules have been developed and placed in supercomputers. For example, bleeding and coagulation, how big a blood vessel to cut, how much blood to bleed, and how long it takes to coagulate are all simulated by functional modules, with countless supporting algorithms.
.”
Academician Xiang is also very familiar with the research on international student digital people, so Academician Xiang of the University of Tokyo is also very familiar with it.
Nandu Medical University used to be the world's leader in digital humans. Later, with the iteration of technology, it gradually fell behind, and the plan for functional human research has not been launched. According to Yang Ping's analysis, Nandu Medical University still has the opportunity to strike later.
The old academician was quite pleased. It was rare for someone to have such a far-sighted vision and be a young surgeon.
"So we need to do research on digital cells? Then do research on the logical relationship between cells forming tissues, tissues forming organs, and finally digital cells forming the human body?" Academician Xiang Lao is already very clear about the entire route proposed by Yang Ping.
"Yes, I think so. Supercomputers are urgently needed, and these studies must be carried out based on supercomputers." Yang Ping said bluntly.
The old academician nodded: "If the research is really successful, this will be a cornerstone scientific research result that can promote scientific and technological progress in many industries."
The two of them were chatting while eating. A bottle of wine had not yet been finished by everyone at the table, and the drinking was done in a casual way.
It took five hours to eat this meal, but the old academician was still not satisfied. Before leaving, Academician Xiang was reluctant to leave Yang Ping.
Yang Ping wanted to find a driver to drive him back, but the old academician refused. Professor He insisted on arranging for an old driver from the logistics department of Nandu Medical University to be his driver to take Yang Ping back.
Everyone parted at the door of the hotel, but Academician Xiang insisted on sending Yang Ping to the car. When he got on the car, he was still discussing the upgrade of digital humans with Yang Ping, and finally told Yang Ping to come to his home to play with Professor He when he had time.
It can be said that Yang Ping and Academician Xiang fell in love at first sight and formed a lifelong friendship.
Saying goodbye to the old academician, Yang Ping thought a lot in the car. Yang Ping was very touched to receive such attention from the old academician Xiang.
Academician Xiang Lao is a leading figure in the basic medical field in the country, a researcher on many important national issues, and the most respected senior academician of Nandu Medical University. When the principal sees Lao Xiang, he always speaks with a bowed back.
The older generation of experts, starting from Professor Zhang Zongshun, to Academician Feng Tiancheng, Professor Xiehe Liang, and then to Academician Xiang Lao, they are really pure people, without many selfish thoughts, and there are many things worth learning by themselves.
At that time, Academician Feng Tiancheng knew that his tumor was incurable and the success rate of surgery was very slim, but he still insisted on having surgery to gain experience for young people. He also specified in his will that an autopsy of the body would be performed afterwards to accumulate pathological data.
As he thought about it, Yang Ping couldn't help but feel filled with emotion.
Thinking of the issue of upgrading digital humans mentioned by Mr. Xiang, Yang Ping also had some thoughts in mind. Digital humans must develop towards refinement and functionality.
Refinement is relative and can progress infinitely, but currently it must at least reach the level of cells, that is, digital humans are composed of digital cells.
As for functionalization, it must at least be able to simulate the known basic functions of the human body, and the basic functions of each organ must be simulated.
For example, if you cut a wound on a digital human body, the wound will bleed, coagulate, the human body's reaction to bleeding, etc., all of which must be able to be simulated.
These data far exceed previous digital anatomy of humans, and the study cannot be completed without supercomputers.
In the future, you can also rely on digital humans to conduct research on your own stem cell research to improve efficiency.
Therefore, with the development of science and technology, computing power is also a precious resource, and supercomputers are the embodiment of computing power.
With functional digital humans, many of Yang Ping’s research data can be directly used for model development and indirectly applied to reality.
In the system space, Yang Ping actually has a large amount of anatomy data, but he cannot take it out all at once. He can only take it out bit by bit as the subject progresses.
And you can't directly give the data. You can only teach others how to obtain the data and let them accumulate the data themselves.
That is, only methods can be given, not data directly.
If you give some data directly, it will make people think that these data are fabricated out of thin air and have no basis.
Of course, if some data can be explained clearly with practical reasons, Yang Ping will also directly come up with the data, which is very rare.
In short, the results in the system laboratory must be presented in a reasonable way. This is what Yang Ping himself said, and it must be realized in a reasonable way.
For example, for the spinal external fixator, the entire experimental process was carried out in reality, and all the data were produced in reality. No data was created out of thin air, so the whole process was reasonable and reasonable. This is the realization of classic system laboratory results.
Yang Ping used a similar method for the stem cell subject. However, because the subject was too large, in order to start as soon as possible in reality, Yang Ping did not wait for the entire subject to be completed in the system laboratory before starting the actual experiment. Instead, he took
The results of the first stage are realized in reality.
In this way, the entire experimental process will be under your own leadership, avoiding trial and error, and proceeding directly along the correct route, which ensures success and takes the least time.
After returning from Nandu Medical University, Yang Ping is more confident about the progress of the project. With the support of Nandu Medical University, the time for this project will be shortened a lot.
Just like the original spinal external fixator, without the strong support of Peking Union Medical College, providing laboratories, animal models, and a large number of doctors as front-line researchers, it would not have been so fast.
Just imagine that there is a complete airplane production drawing, and qualified engineers, workers, factories, and raw materials are needed to manufacture the airplane.
The results Yang Ping obtained in the system laboratory were "drawings", and he needed manpower, material and financial resources to realize them.
When Yang Ping came back, it was already twelve o'clock in the evening. Xiao Su had not gone to bed yet. He had been waiting for Yang Ping and fell asleep on the coffee table in the living room in his pajamas.
When Yang Ping entered the room, she rubbed her big sleepy eyes and said, "You're back!"
Then he went to help Yang Ping prepare clean pajamas and let Yang Ping take a shower and rest early.
Yang Ping hugged Xiao Su and kissed her on the forehead.
As a surgeon in a tertiary teaching hospital, I am involved in surgeries and scientific research. I really don’t have much time to spend with my family, so it is very important to have a wife who understands me.
Xiao Su is an instrument nurse and can see Yang Ping in the operating room every day. The two of them can be regarded as staying together in another way.
"Did you drink today?" Xiao Su asked distressedly.
Yang Ping nodded: "Little by little, I ate with Academician Xiang. The old man was happy and wanted to drink some wine, so I drank with him. Everyone at the table didn't finish a bottle of wine."
"It's okay. I'm just asking. He rarely attends dinner parties. You have a lot of face." Xiao Su reached out and touched Yang Ping's nose.
Xiao Su is very familiar with the people and things of Nandu Medical University.
"Go take a shower and go to bed early. There are so many surgeries tomorrow." Xiao Su said to Yang Ping tenderly. She not only prepared pajamas, but also squeezed out toothpaste.
Recently, I learned that Yang Ping was busy with a project, and Mrs. Su's urge to get married has relaxed a lot.
Professor Su came up with a good idea, a new approach in the new era, and asked Yang Ping and Xiao Su to pick a date to go to the Civil Affairs Bureau to get the certificates. As for the wedding, they should do it later when they have time.
So Yang Ping and Xiao Su were thinking about one day to go to the Civil Affairs Bureau to get the certificate.
——
The next day, Yang Ping finished a day's surgery and went to participate in the case discussion between Qin Xiaowei and Li Jun.
The notification phone number from the Medical Office said that experts from other hospitals were also invited to participate in the discussion.
After Li Jun was taken offline, his vital signs were stable and he was transferred to the Department of Respiratory Medicine. He spent more than two million yuan in the ICU and finally saved his life.
During his stay in the ICU, because the arteriovenous fistulas on both sides of his upper arms had been occluded and thrombi were formed that were more than ten centimeters long, thrombolysis and thrombectomy could not be performed, and the upper limb dialysis access was basically exhausted. The ICU and dialysis department temporarily placed him in the right femoral vein.
A catheter was temporarily inserted to meet the short-term hemodialysis needs. Later, an arteriovenous fistula was formed in his left lower limb. Not long after, the left lower limb became occluded again. The arteriovenous fistula was formed in the right lower limb. Now, the right lower limb has begun to become blocked again.
signs.
The amount of fluid required for each dialysis session is getting smaller and smaller, and the effect is getting worse and worse. Li Jun's urgency for a kidney transplant is growing.
Qin Xiaowei is still in the ICU, but his vital signs are still stable. However, due to severe liver failure, he can only rely on an artificial liver to maintain his life, waiting for a subsequent life-saving liver transplant.
After all, the artificial liver is not as good as the normal human liver. If the liver failure is only caused by the liver disease, Qin Xiaowei can wait half a year to a year with the artificial liver. However, Qin Xiaowei has liver failure caused by heat stroke, and liver failure is only his problem.
It is the initial stage of multi-organ failure. If the artificial liver does not work well in the future, there is a high chance of triggering multi-organ failure.
Therefore, Li Jun is eagerly waiting for a liver transplant.
After Li Jun learned about Tan Xiaowei's condition, he offered to donate his liver to Tan Xiaowei without hesitation, which was expected by everyone.
The fates of the two people are so wonderfully intertwined.
This kind of two-way donated organ transplant is not very common, so the organ transplant center attaches great importance to it. At present, both surgeries are urgent and dangerous.
The more contradictory problem is that one of the two people is still in the ICU, and the other has just come out of the ICU. Both of them cannot bear the impact of the surgery, and the risks of the surgery are extremely high.
Moreover, whether it is a liver transplant or a kidney transplant, when the organ is taken out from the human body, processed and then transplanted into another human body, there is an ischemic period. This ischemic period will damage the organ and lead to a decline in the function of the early transplanted organ. After liver transplantation, aspartate aminotransferase is at a low level.
High levels, and creatinine is at high levels after kidney transplantation, the probability of this event occurring exceeds 50%.
This is fine for ordinary patients, but for Qin Xiaowei and Li Jun, it is fatal. It can easily trigger multiple organ failure, and eventually the entire organ function system will collapse.
During this time, Yang Ping was also thinking about these two cases, when and how to perform the surgery.
Director Liu of the kidney transplant department and Director Li of the liver transplant department also attached great importance to these two cases, hoping to complete the operations at the best time. However, due to the complexity of the condition, they did not dare to act rashly.
Qin Xiaowei and Li Jun have no relatives and are both alone. They can make decisions on their own without any interference from others. Both of their donated organs have passed ethical review and the matching has been very successful.
In this case, there is little external interference, and the rest is how the doctor decides the timing of the operation.
Speaking of which, these two are also poor children. According to Dr. An, when Li Jun was seven years old, his mother abandoned him and his father, ran away with others, and took away the family's money. Later, when Li Jun was ten years old, his father was at the construction site.
After his death in an accident, Li Jun stayed with relatives until he was 15 years old and then came out to work to earn a living.
Qin Xiaowei is not much better. He had no parents and grew up in an orphanage. He also came out to explore the world in his teens.
Fortunately, Qin Xiaowei raised the money this time and did not give up on Li Jun. He asked the ICU doctors to fight for Li Jun's life. Without Qin Xiaowei's persistence at that time, Li Jun would definitely not be alive today.
Li Jun is now willing to risk surgery and donate part of his liver to save Tan Xiaowei.
However, Director Liu and Director Li of the transplant center have to consider various factors, and there are still many difficulties in the operation.
Director Liu and Director Li are in a dilemma. If we perform surgery now, the doctor will be at great risk. If we don’t do surgery now, the patient will be at even greater risk in the future, and his life will be in danger at any time.
Should we take a gamble at this point? If the gamble succeeds, both of us will be better off, but if something goes wrong, even if one party goes wrong, it will be catastrophic.
If they don't gamble, the two of them basically don't have much time left.
Director Liu and Director Zhao were really unsure.
So we called everyone together to discuss and discuss, and also invited experts from other hospitals.
Especially now that Tan Xiaowei is a celebrity, the two directors are even more stressed. If anything goes wrong, they may face the risk of cyber violence.
