Chapter 465 Forget about hydrology (please subscribe)
Author: A lancet
Chapter 465 Forget about hydrology (please subscribe)
Before applying for a topic, by searching the literature and current research progress, you can only see published content and published articles.
You will basically not pay attention to or inquire about the experimental progress or proposed projects of other research teams. Therefore, in fact, someone may be trying the research direction of each topic, and the results may be available at any time.
Once such a situation occurs, then you can only think of other ways to solve the problem.
However, this article published in Science does very in-depth research.
Therefore, after Fang Yun told Yang Yifeng about this, Yang Yifeng couldn't sit still at all. Not only Yang Yifeng couldn't sit still, but even Ding Changle personally came out to defend Yang Yifeng at this moment.
Not only did he call all his students, but he also specially invited the director of neurosurgery, Professor Jiang Hong, to help Yang Yifeng think about the next steps.
Zhou Cheng and Fang Yun were also invited, and they were surrounding Ding Changle's laboratory. The door of the laboratory was closed tightly.
"Yi Feng, please tell me what is going on, and then we can think of a solution together. After a while, I will think of other ways out." Ding Changle saw that everyone had arrived, so he gave the order, nothing special.
panic.
Yang Yifeng was his student. Being admitted to the hospital at such a young age and winning the lottery was considered one of his reputations.
Moreover, Yang Yifeng is a recognized genius in the hospital. If he won the bid, no one would suspect that it was fake. However, today's incident can be regarded as the worst of eight lifetimes.
Moreover, his topic was published in a top-notch journal such as Science. If this is not handled well, it will really be impossible to solve the problem and it will be difficult to finish it.
Even in the end, the managers of the National Natural Science Foundation of China came to trouble Yang Yifeng, saying that when he applied for the project, he did not have enough early reserves.
Of course, even for such a reason, Ding Changle had to find a way to let Yang Yifeng go around.
Yang Yifeng was holding his own tender document and a ppt that he had already prepared.
At this moment, his face was full of seriousness: "Master, Professor Jiang Hong, fellow brothers, thank you for your hard work. This time, the subject I plan to apply for is in the field of nerve healing."
"The details are as follows. You can read the contents of my ppt. I won't gossip..."
"Nerve repair is currently a very popular research direction in many departments such as hand surgery and neurosurgery. The meaning of its existence is that even after the nerve is severed, it can be sutured."
"Even with the best current nerve suturing technology and the best suturing objective conditions, there will be a loss of nerve function after healing, or even non-healing. This is the background and role of the significance of the research."
"The background of my choice of topic is as follows."
As Yang Yifeng spoke, he clicked on the ppt and introduced it to everyone.
In fact, at Yang Yifeng's level, the topics he studies are not among the top people in the world. It can also be said that in the field of his research, there are not many people who can match the depth and knowledge base in the field he studies.
He compares.
Because Yang Yifeng worked out the direction himself and did a lot of collecting work, if we want to find a solution now, we must also lay out the basic research background.
It is equivalent to explaining all the research mechanisms and ideas on this topic, so that everyone can help to find solutions together, instead of asking everyone to find or collect information on their own, wasting time.
"The concept of nerve healing refers to the process of restoring normal function to damaged parts of the nervous system."
"In recent years, not only our country, but more and more research teams around the world have begun to study and focus on the mechanism of nerve healing and explore related popular targets and healing mechanisms. The following are several popular mechanisms.
And some of their simple action processes.”
"The first one, and the most popular understanding at present, is that all healing is inflammatory healing, so nerve healing is no exception."
"So?"
“The application of inflammation and immune system modulation in the nervous system is—
"After the nervous system is damaged, the regulation of local inflammatory response and immune system plays a key role in nerve regeneration and repair. Therefore, regulating the inflammatory response and immune system of the nervous system may be an important target to promote nerve healing."
“Nerve growth factors and neurotransmitters: Nerve growth factors and neurotransmitters are important molecules that affect neuron growth and regeneration to promote nerve regeneration and repair.
"Extracellular matrix: The extracellular matrix refers to the supportive tissue surrounding cells and plays an important role in nerve regeneration and repair."
"Gangliosides and other molecules: Gangliosides and other molecules are signaling molecules between neurons and their surrounding environment, and they can influence neuron growth and regeneration."
"The above are popular research directions, and among these directions, the articles published this time are all involved. The published articles describe a very comprehensive topic and the conclusions reached after the collaboration of multiple researchers.
"
"Regarding the research on inflammatory response and immune system regulation in nerve healing, some studies have shown that local inflammatory response can play a positive role in the process of nerve regeneration and repair, but excessive inflammatory response may have a negative impact on nerve regeneration. Therefore,
Finding molecules and drugs that regulate the inflammatory response and immune system has become a current research hotspot."
"In recent years, some drugs that regulate the immune system have been proven to promote nerve healing, such as some anti-rheumatic drugs, glucocorticoids, neuropeptides, etc. In addition, some cytokines such as interleukin-10 (IL-10), transform
Growth factor-β (TGF-β) and others have also been found to regulate the inflammatory response and immune system, thereby promoting nerve healing."
"The paper published this time covers the role of interleukin-10, a cytokine, in nerve healing."
"Then if we want to go deeper, we can either do the parallel pathway of IL-10, or we can do the role of the upstream and downstream pathways of IL-10."
"When I searched the literature before, I found that the upstream and downstream pathways are basically complete and have no groundbreaking significance. Therefore, it is a redundant, or exclusionary, exploratory study."
When Yang Yifeng said this, he only explained the background of one of the research paths.
Seeing that no one responded, Yang Yifeng continued to dig deeper:
“And in terms of nerve growth factors and neurotransmitters!”
"The role of nerve growth factors and neurotransmitters in nerve healing has been widely recognized. Nerve growth factors are a class of proteins that promote neuron growth, differentiation and regeneration."
"Among them, neurotrophic factor (NGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and nerve growth inhibitory factor (GDNF) have been proven to promote nerve healing. In addition, neurotransmitters are a
A class of chemicals that transmit signals between neurons, of which acetylcholine and norepinephrine are common neurotransmitters."
"Corresponding drugs such as clonidine and lidocaine have also been found to promote the release of neurotransmitters, thereby promoting nerve healing."
"However, neurotrophic factors have a certain overlap with inflammation in promoting nerve healing, so this research aspect is also covered in this study."
"This drug can also promote nerve healing by promoting the secretion of nerve growth factors."
"The third one is the recognized new application of extracellular matrix."
"Extracellular matrix plays an important role in nerve regeneration and repair. In recent years, many studies have developed some materials with extracellular matrix components that support nerve regeneration, such as nerve regeneration biological scaffolds. These biological scaffolds can provide neurons with
Providing a suitable physical and chemical environment to promote the growth and connection of neurons. At the same time, some extracellular matrix degradation enzyme inhibitors have also been shown to promote nerve healing."
"In this study, this aspect was also applied, and they also used this material as a medium to obtain preliminary data in animal experiments."
"Then there are neural stem cells and stem cell factors. Neural stem cells are a type of multipotent stem cells with the ability to self-renew and differentiate into neurons and glial cells. Some studies have shown that by implanting neural stem cells, nerve regeneration and repair can be promoted, thus
Improve the recovery of neurological function..."
As Yang Yifeng went deeper, everyone fell into a brainstorm. At the same time, almost everyone cast pitiful looks at Yang Yifeng.
What the hell happened to you that you ended up in this project?
This other person has basically done everything you need to do after being introduced to you, so what else do you have to do?
This is purely unlucky, because when Yang Yifeng applied, other people's results had not yet been published, and it was impossible to publish half of the results. Then as soon as Yang Yifeng applied for the project, others had already published the article.
The difficulty now is not entirely that Yang Yifeng cannot continue to go deeper, but how to go deeper and how to find the best direction with limited funds.
Of course, it is quite difficult to achieve results similar to this, or to go further, and if we want to continue doing it in depth, we will have to pay according to the temporary funds provided by Yang Yifeng.
At least five million or more.
The total funding for the project that Yang Yifeng applied for was less than 300,000 yuan, a difference of many times, and this gap was not even something that Yang Yifeng could fill with his own salary.
Ding Changle looked at Jiang Hong.
Jiang Hong sniffed, shrugged his eyelids, and said in a helpless tone: "Yi Feng, are you just poking a hornet's nest?"
"When you applied for the project, what were your expected results?"
"The expectations are not high. I just publish three SCI papers and train one doctoral student and three master's students."
"If these 300,000 yuan are used only to publish articles, it will be enough to find loopholes and fill in the gaps. But if it is to be used as the preliminary basis for subsequent research directions, it is obviously not enough."
"I thought." Yang Yifeng hesitated before speaking.
He is unwilling to waste the country's money on meaningless things, not just because of his own pride.
What’s more, Zhou Cheng is currently doing research projects, and all clinical projects are going smoothly, but he has overturned the situation. How will he cooperate in the future? People who don’t know think that he, Yang Yifeng, is just following Zhou Cheng and is just trying to lick the dog.
So, this time, he wanted to brainstorm and discuss it, hoping to find a more novel angle.
Zhou Cheng had just finished reading that article. To be honest, the research level of this article was relatively broad and in-depth, almost blocking the direction of Yang Yifeng's current research topic!
However, when Zhou Cheng was simulating neural suturing before, he saw other things.
"Yi Feng, if nerves heal, there should be other pathways besides these pathways, right? Have you ever understood it?" After Zhou Cheng finished reading the article, he spoke first without waiting for anyone else to speak.
Now he no longer needs to be too modest and save face for Ding Changle and others.
Big articles, big topics, innovative topics, global topics, Zhou Cheng has a resume, what qualifications do you want to talk to me about?
Zhou Cheng spoke frankly, and he believed that Ding Changle would not be surprised. If he was not thoughtful, Ding Changle would not be able to take the position of director of the Department of Orthopedics.
However, Ding Changle is obviously more concerned about the progress of this topic than Yang Yifeng: "Did Xiao Zhou have a better idea?"
Zhou Cheng shook his head first and thought to himself, isn't it a lie that I can surpass Yang Yifeng and understand him so deeply?
"I think I saw Professor Ding when I was checking the literature."
These things are not within the knowledge threshold that Yang Yifeng is proficient in, so it takes a while to search.
Then, Yang Yifeng nodded, and showed his strong knowledge and knowledge control ability unhurriedly: "Yes, there are three main aspects."
"First, brain-derived neurotrophic factor, brain-derived neurotrophic factor (BDNF), is a nerve growth factor that plays an important role in the growth, differentiation, maturation and survival of neurons. Research shows that BDNF can not only promote
The growth and connection of neurons can also improve neuronal metabolism and reduce cell apoptosis."
"Therefore, by increasing the level of BDNF or enhancing its function, nerve regeneration and repair can be promoted. Some studies have shown that the use of BDNF or its mimics can promote nerve regeneration and repair, and has achieved certain clinical effects."
"Second, gene therapy. The ethics cannot be passed!"
"Third, optical neuromodulation technology."
"This is a technology that uses light-sensitive proteins or compounds to stimulate and regulate neurons. This technology can precisely control the activity of neurons in space and time, thereby achieving the effects of nerve regeneration and repair..."
"The reason why these three aspects are not common is that they cost more money to carry out and the expected results are very limited."
"Then you don't have a solution? I think you can spend more money, transfer the funds within the research group, write a few articles and complete the problem." Jiang Hong said.
Nerve healing is a relatively basic research and is not new. Basic means that the research is extensive and lasts a long time. After this big article is published, no one will touch it for at least ten years.
Why should Yang Yifeng continue to be entangled and persistent?
Ding Changle looked at Yang Yifeng, almost convinced that Yang Yifeng could only finish the question with a water article, and asked: "Yifeng, write a few articles, you should be fine, right?"
Yang Yifeng has done too much homework, and what he expressed is too detailed. Basically, there are not many gaps for others to explore, so stop thinking about big topics and big articles.