As soon as Xu Yun returned to the laboratory, he asked Qiu Sheng, who was holding a test tube:
"It only took more than an hour, right? The replacement reaction was completed so quickly?"
"That's right, wait until I put this thing away first."
Upon hearing this, Qiu Sheng carefully put down the test tube, walked to another table, picked up a paper report, and handed it to Xu Yun:
"To be precise, it was one hour and twenty-seven minutes. The activity of 5-epoxy-1-hexadecene seems to be much higher than we expected."
Xu Yun took the report, glanced at it a few times, and nodded:
"This kind of curve... seems to be a temperature setting problem, probably related to the fact that I just asked Xiao Zhao to increase the temperature.
Lao Qiu, I am not specialized in chemistry. Is the activity of 5-epoxy-1-hexadecylene so different at 180 degrees and 170 degrees?"
Qiu Sheng pondered for a while and shook his head:
“I know about 5-epoxy-1-dodecene, hexacarbonacetylene...it seems that the understanding of it in China is relatively limited.
The two temperature environments of 180 and 170 are quite common, but adding a substitution reaction is hard to say. After all, carbyne... there is still more research in materials science."
Xu Yun nodded thoughtfully and stopped talking.
Carboyne refers to a chain of carbon atoms joined together by double bonds or alternating single and triple bonds.
Carboyne has been proven to be more than 200 times stronger than steel and twice the tensile strength of graphene. It is considered the strongest material in the world and is 40 times stronger than diamond.
It was proposed in 1885, but it was not until April 21, 2016 that the University of Vienna developed a carbon chain composed of 6,400 carbon atoms.
From a mass production perspective, it is indeed a new product.
Epoxycarboyne is more complicated, and Xu Yun did not actually expect it to be the final product.
The main purpose of introducing this substance is to enable the reaction of epoxy terminal alkynes with 1-bromo-2-pentyne under the catalysis of copper iodide to form epoxydiyne.
Finally, through catalytic hydrogenation of nickel acetate/sodium borohydride, the target pheromone (3Z, 6Z, 9S, 10R)-9,10-epoxy-3,6-icosadiene is obtained.
Therefore, 5-epoxy-1-hexadecene is an intermediate product in the entire reaction. Xu Yun’s original idea was just to hope that it could stably play a connecting role.
But judging from the current situation...
This thing seems to have some more active chemical properties under certain circumstances?
Xu Yun silently kept this situation in mind and planned to take the time to ask a more professional boss. At the same time, he said to Qiu Sheng:
"Okay, let's continue."
Qiu Sheng nodded, followed Xu Yun back to his position, and started operating again.
Perhaps it was because we had eaten at noon. Compared with the relatively dry running-in in the morning, everyone in the research group in the afternoon seemed to have added lubricant, and they went in and out very smoothly.
After working overtime all night, the research team finally synthesized the target pheromone in the early morning of the next day, nearly ten hours earlier than Xu Yun originally expected.
.........
A night of silence.
At 1:30 pm the next day, Xu Yun stood in front of the main operating desk again.
"Dear juniors and juniors."
He looked around, and the last time he saw this kind of scene of six people gathering in his memory seemed like yesterday:
"After everyone's unremitting efforts yesterday, we have finally passed the first step of this project. Without further ado, let's get started tonight!"
"Pah, pah, pah—"
As soon as he finished speaking, Tang Yiqiu and others burst into applause.
Then Xu Yun paused and continued:
"In addition, starting from today, we will carry out the synthesis of pheromones and imidacloprid. This link mainly consists of two steps:
One is the directional cyclization of a CH3 through asymmetry, and the other is the synthesis of new substances.
The structure of the target pheromone we synthesize is very complex, and no one is sure whether one CH3 can be accurately removed for cyclization, so everyone is asked to work together to achieve a good result!
Okay, that’s all I need to say, let’s start the experiment!”
As he spoke, he waved his hand and everyone returned to their seats.
Xu Yun came to the main operating table and took care of the main steps himself.
"Xiao Tang."
Xu Yun made preparations carefully and said to Tang Yiqiu:
"Add protective argon first!"
"clear!"
After the argon gas was added, Xu Yun began to add 50 m of anhydrous LTHF and 20 grams of hexamethylphosphoramide into the 250 mL Schlenk reaction bottle, and stirred to dissolve.
After the treatment was completed, he lowered the temperature of the reaction system to -78°C, added 2.52 g of propargyl alcohol, then added n-butyllithium dropwise with a syringe, and raised the temperature to -30°C.
After another three hours, the stirring reaction was sufficient to occur.
"Xiao Tang, prepare 22.50mmol of 1-bromoundecane!"
at the same time.
In the invisible realm of onlookers, some subtle reactions are quietly taking place.
LTHF, strictly speaking should be called LT-HF.
The former means low temperature, which is low temperature, and HF means hydrogen fluoride.
LTHF and hexamethylphosphoramide are like two boys and girls who are just in love. They like each other but dare not express it. They struggled for a long time, but they only advanced to the point of borrowing an eraser.
At this time, the unsightly 1-bromoundecane appeared.
It was like a common little gangster in novels, blocking the weak hexamethylphosphoramide in one afternoon.
"Don't come over, let go!"
"Hey, hey, little sister, do you want to be a dua?"
1-Bromeundecane approached hexamethylphosphoramide, forced her into the corner, and even grabbed her little hand.
"Stop it!"
At this moment, LTHF, a pure love boy without the attributes of a minotaur, appeared. He first picked up a stone from the floor (a hydrogen decomposed on propargyl alcohol) and threw it hard towards 1-bromoundecane.
.
The stone hit 1-bromoundecane hard, splattering a red blood stain (three carbons).
Then, while 1-bromoundecane was covering its head and wailing, LTHF picked up hexamethylphosphoramide, turned around and ran away.
After running into a deserted alley, HMP raised his head and looked at LTHF with six pairs of methyl eyes filled with tears:
"Why did you save me?"
LTHF smiled and scratched the back of his head, his eyes wandering:
"Because...because..."
After mumbling for a long time, he still didn't have the courage to say "I like you" out of his mouth.
Just as the young man hesitated and hesitated to speak, he suddenly felt a soft moistness at the corner of his mouth.
His eyes widened in an instant, and he looked straight in front of him blankly, but suddenly he met six pairs of loving eyes.
Hexamethylphosphoramide stretched out three hands representing nitrogen, tightly surrounding LTHF, and the second mouth representing oxygen said Nunuo:
"LTHF, I like you..."
"Snapped!"
At the same time, in the laboratory, Xu Yun clapped his hands heavily:
"Perfect, the reaction is complete!"
Please remember the first domain name of this book: ._