Just like that, Chen Nan found a small restaurant and went in.
I had been hungry all morning and planned to order a few dishes, but I couldn't order alone, so this was a good time.
The hotel is called "Erhe Hotel". Although the store is not big, it is clean.
"Ouch, here it comes!"
When the boss saw Chen Nan coming, he immediately smiled and said hello.
During this period, Chen Nan ate here every day. He came and went and became familiar with the boss.
It was originally a small mom-and-pop shop, but now that it's past dinner time, there aren't many people.
"What do you want to eat today?"
Chen Nan smiled: "Director Yang, Professor James, do you have any taboos?"
James smiled and said, "No, I just came over to have a chat with Director Chen. It doesn't matter what you eat."
Yang Fupeng nodded and smiled: "I see you are a regular customer. Just order a few of your favorites. I won't pick."
Chen Nan smiled and ordered a few dishes without looking at the menu:
"Shredded pork with green pepper, tomatoes and eggs, fried sausage with green onions, shredded pepper tripe, fried liver, and a West Lake beef soup."
"Three pieces of rice."
"thank you boss."
"This should be done better and we have international friends."
"If it's done well, it will enhance its international reputation."
The boss, whose surname is also Chen, is Chen Erhe. When he heard this, he immediately laughed: "Okay, you guys sit down, I'll go get ready now."
…
The landlady poured three cups of hot tea and put them on the table, then stopped disturbing the three of them.
At this time, James Hacken looked at the time and said to Chen Nan:
"Director Chen, I'm really sorry to bother you at this point."
"It's just that I am currently conducting research on digestive tract tumors and precancerous conditions, and I am in a certain confusion."
"This time I came to the China-Japan Friendship Hospital in the hope of seeking some cooperation."
"Unfortunately, Professor Yu Jinhua is not good at clinical research. He is better at treatment than scientific research."
"I think Professor Yu is more like a craftsman than a scientist."
"He has a very good craftsmanship spirit and is good at studying and improving, but he lacks pioneering and innovation."
James Hacken is sixty-three years old this year. He has a full beard, a gentleman's hat, and a straight suit. He is indescribably awkward with the fly house at this time.
However, the other party didn't care at all.
Instead, he discussed it directly with Chen Nan in detail.
"Director Yang said that you are very knowledgeable about traditional Chinese medicine, so I hope to have a good chat with you."
After finishing speaking, he meticulously took off his hat and placed it on the chair. At the same time, he unbuttoned his black coat, took out a notebook and a pen from the lining pocket, and placed them on the table.
It can be seen from these details that Professor James is definitely a serious and meticulous person.
This kind of person is actually very suitable for doing research.
Chen Nan smiled: "Well, let's just chat. Professor James, you are a senior and can't be called advice. It's just a simple academic exchange."
James smiled: "Well, okay!"
"Director Chen, you should know something about atrophic gastritis accompanied by intestinal metaplasia."
When Chen Nan heard this, his eyes suddenly lit up.
Because... Mi Lei is currently conducting research on a topic that has even achieved certain results.
On the reversal of chronic atrophic gastritis with intestinal metaplasia.
"You continue." Chen Nan did not interrupt the other party.
At this time, James Hacken took out a printed piece of paper from his pocket and handed it to Chen Nan:
"Director Chen, please take a look at this first. This is a paper I am preparing to publish."
"Previous studies believe that gastric mucosal lesions have an "irreversible point", that is, once intestinal metaplasia occurs, no matter how much attention is paid and how much treatment is given, it is difficult to reverse. The only way is to wait for it to progress and to review the gastroscopy; so
Many patients diagnosed with intestinal metaplasia carry heavy ideological baggage, and some even suffer from depression."
"But actually, that's not the case. After doing a lot of research, I discovered something."
"Actually, intestinal metaplasia is not irreversible!"
"Intestinal metaplasia (IM) is the abbreviation of gastric mucosal intestinal metaplasia. After atrophic gastritis occurs, gastric mucus secretion will decrease. To make up for the lack of mucus secretion, the gastric mucosal layer will repair itself and use goblet cells to secrete
Mucus, because these cells are similar to the goblet cells of the small intestine and large intestine, it is called intestinal metaplasia.”
"To put it simply, cells that should have been in the intestine grew on the gastric mucosa, that is, they grew in the wrong place. First of all, they did not undergo abnormal changes.
Second, it still has a basically normal cell shape. Although people say it is a "precancerous lesion/state", in fact, it is basically a good child, but it just entered the wrong door."
Chen Nan nodded. He had also participated in understanding this during Mi Lei's experiment.
Although I am not familiar with the specific process, I am not unfamiliar either.
At this time, James Hacken suddenly said: "Nowadays, published literature rarely talks about the reversal of intestinal metaplasia.
However, my research over the past few years has shown that with standard treatment, especially the eradication of Helicobacter pylori, at least 1/3 of intestinal transformation can be reversed."
"This shows that there is a key to this problem!"
"But, I feel that one third is not the end!"
"I don't want to publish immature data and mislead many people!"
"I feel that there must be many problems in our research!"
"So, I'm hoping to get some inspiration."
At this time, the boss smiled and served a plate of tomatoes and eggs.
Chen Nan became slightly thoughtful.
Seeing that Chen Nan was silent, Yang Fuleng and James Hacken were a little anxious and even a little confused.
Seeing that all the dishes are being served.
James Hacken couldn't bear it anymore: "Director Chen, why don't you speak."
Chen Nan suddenly laughed when he saw the shredded tripe, fatty intestines and fried liver that were served.
"Professor James, do you know these dishes?"
When James Hacken heard the sound, he was immediately speechless. He widened his eyes and looked at Chen Nan with some confusion.
He even felt that he... was crazy and came to see him.
Why is this person like this?
If James Hacken hadn't been so well-educated, he would have scolded his mother and left long ago.
"I don't know him. Could you please introduce me to Professor Chen?"
Chen Nan smiled and said: "This is tripe, a dish made from animal stomachs."
"Try it."
James didn't hesitate, nodded, picked it up and tasted it.
"This is fried liver. Old BJ's fried liver is very famous. It uses pig's large intestine and liver as the main raw materials. This dish also has very high requirements for heat. When it is ready, the soup will be bright and red, and the liver sausage will be fat.
, the flavor is rich but not greasy, thin but not dull, and the taste is mellow.”
"Try it."
Then, Chen Nan pointed to a plate of fat intestines and said, "This is fat intestines."
"Made from animal intestines."
"Try it."
Although James Hacken was puzzled, he still tasted the food one after another. It tasted really good and he couldn't help but take a few more bites.
but……
After eating, he immediately realized something was wrong.
This...how could you forget the real thing?
He quickly looked at Chen Nan: "Director Chen, I come to ask you for advice with a pious attitude."
"Aren't you a little bit deceptive?"
When Chen Nan saw James Hacken, instead of being angry, he smiled and said, "Actually, I already said the answer just now."
When James Hacken heard this, he was stunned!
How can this be?
Didn’t you just let me eat a few dishes?
Why did you just tell me the answer?
Isn't this a joke?
Even Yang Fupeng looked at these dishes carefully with wide eyes, trying to see some clues.
At this time, Chen Nan returned the paper with the research results that James Hacken had just handed him.
Then, he said:
"Actually, Professor James, if I'm not wrong."
"The theory that at least 1/3 of your so-called atrophic gastritis with intestinal metaplasia can be reversed is just your conjecture, or a theoretical conjecture, right?"
As soon as these words came out, James Hacken's eyes widened and he looked at Chen Nan in disbelief.
"No!"
"I've made hypotheses and experiments."
"Of course it's not a simple guess."
Chen Nan asked back: "Then do you have a specific ratio?"
James Hacken was silent and shook his head: "No!"
Chen Nan smiled: "That's right."
"Actually, your research has been narrow from the beginning."
"Intestinal metastases are called "precancerous lesions" because:
1. After the proliferation center in the gastric mucosal gland is stimulated by carcinogens, its undifferentiated cells undergo genetic mutations, open intestinal-type genes, and differentiate into intestinal-type cells. If the cells continue to develop in an unfavorable direction, their differentiation will become worse and worse, and eventually
develop into gastric cancer.
2. With the atrophy of gastric mucosal glands or the reduction in the number of parietal cells, mucosal parietal cells are destroyed, glands atrophy, gastric acid secretion decreases, and the pH value in the stomach increases, inducing the stem cells in the gland neck to differentiate toward the intestinal mucosa, and ultimately
Dysplasia and gastric cancer occur."
"These things can only explain one problem!"
"That is the internal environment, which causes the gastric mucosa to be in an environment that is not easy to survive and is prone to alienation."
"Is it right?"
After hearing Chen Nan's words, Yang Fupeng suddenly turned serious and his eyes became extremely solemn.
And James Hacken quickly opened his notebook and started writing on it.
Chen Nan continued:
"Look, those dishes, the stomach, intestines... are obviously all digestive systems, but why are the textures so different?"
"This is actually what is called intestinal metaplasia."
"Why?"
"Think about the living environment of intestinal cells and the living environment of gastric mucosal cells."
"Can it be the same?"
James Hacken immediately closed his eyes and meditated without saying a word.
Chen Nan, on the other hand, took his time and analyzed while eating.
Yang Fupeng didn't dare to disturb the two of them and wanted to eat, but...looking at Chen Nan, he always felt that he didn't deserve to eat.
Damn it, how can we discuss academic issues over a meal?
In fact, Yang Fupeng has already decided to pay attention.
I will never eat alone with Chen Nan in the future.
Otherwise you will die of embarrassment.
Just kidding, Yang Fupeng is certainly not an ordinary person. As a young and middle-aged leader in the field of oncology in China, his abilities are naturally very powerful.
However, I have to say that he felt that he still underestimated Chen Nan.
Even though he has raised his opinion of Chen Nan a lot, looking at it today, it seems... it's not enough!
How powerful is this young man?
He always felt that a great result could be achieved in this "Erhe Hotel" today!
Thinking of this, Yang Fupeng hurriedly took a few bites of fried liver to calm down his shock.
I have to say, it tastes really good.
At this time, James suddenly looked at Chen Nan: "Director Chen means..."
"Am I on the wrong track from the beginning?"
Chen Nan nodded: "That's right!"
"You study gastric mucosa and intestinal metaplasia, but you simply study the environment in the stomach."
"It is undeniable that Helicobacter pylori is indeed an important pathogenic factor."
"But...you know what? Professor James."
"In China, the human body is a whole!"
“Traditional Chinese medicine diagnoses and treats diseases, and it never treats stomachaches and headaches.”
"This is narrow-minded thinking."
"Although modern medicine's target cell technology for tumors is very powerful, I still feel that it is on a relatively narrow road."
"That's too far!"
"Let's talk about atrophic gastritis and intestinal metaplasia."
"Actually, I am also doing research on this topic and have even done data analysis."
"I made a detailed statistics on the conditions that lead to this disease. There are a large number of such patients in traditional Chinese medicine syndrome types. Based on the syndrome theory analysis, I divided the probability of the symptoms into: liver and stomach qi stagnation; liver and stomach qi stagnation;
Stagnant heat, dampness and heat in the spleen and stomach, gallbladder heat invading the stomach, Qi stagnation and phlegm obstruction, weak spleen and stomach, insufficient stomach yin and mixed cold and heat.”
"That explains something!"
"That is, stop simply studying the conditions in the stomach, such as gastric acid secretion, gastric mucosa, and Helicobacter pylori."
"Maybe if you open up your mind, you might be able to discover something newer!"
"For example, study it from the perspective of liver, gallbladder, etc.!"
As soon as these words came out, James Hacken's body suddenly trembled with excitement.
He looked at Chen Nan with a solemn expression.
"You mean..."
Chen Nan smiled: "Professor James, this is an academic discussion. I am giving you an inference from the perspective of traditional Chinese medicine and clinical data."
"What do you think is the most connected thing between the liver and the stomach?"
After James heard this, his mind was like a flood bursting, with countless data and images pouring in.
Chen Nan really gave him a great suggestion!
This trip was really not in vain.
As Chen Nan said, my own path was relatively narrow from the beginning.
What an enlightenment!
At this moment, James Hacken really felt a sense of enlightenment.
"Director Chen, I cannot thank you enough for your kindness!"
"If I have research results, I will definitely share them with you."
"This is your honor!"
"My time here is limited, so I won't disturb Director Chen for dinner. I'll treat you next time you come back."
"Bye now!"
Seeing James leaving in a hurry, Yang Fupeng looked at Chen Nan in surprise: "You...how old is your kid?"
Chen Nan looked confused: "26?"
Yang Fupeng rolled his eyes: "Why do I always think you have 260?"
"Pooh!"
"You kid, you're evil!"
"Come, eat, eat, eat, this store is really good."
…
…
The next days passed quickly.
After James Hacken returned to the United States, he directly collaborated with laboratory staff to start "research on the effect of bile on gastric mucosal intestinal metaplasia."
Chen Nan said a lot, but James Hacken grasped one point instantly.
That is bile, which may be the key factor connecting the liver and stomach.
This time's research is not too difficult and does not require a lot of time.
Because they have conducted extensive research before.
Much of the data is readily available.
finally!
Under the study of a large number of data samples, experimental data, and clinical data.
A new idea was proposed by James Hacken!
"The impact of bile reflux on intestinal metaplasia in chronic atrophic gastritis."
That’s right!
They found that a large number of patients had bile reflux.
Bile reflux is actually not proposed now, but because the mechanism by which bile acids cause intestinal metaplasia is not yet clear, there is no clear standard on whether it affects intestinal metaplasia.
and……
still have a question!
That is, it is difficult for Western medicine to treat from this perspective.
so!
In the treatment of bile reflux with intestinal metaplasia, Western medicine only focuses on reducing the cause of bile reflux, and it is difficult to improve or reverse intestinal metaplasia.
This is why this theory has been shelved.
Medicine is not such a benevolent subject.
Those so-called experts are nothing more than speaking for the forces behind it.
If it weren't for capital.
If it weren't for power and political needs.
You can trust what the experts say, but you can't trust them all, otherwise... you will be the one who suffers.
After James Hacken obtained this result, he began further in-depth research!
About the various effects caused by bile reflux.
All of a sudden!
His research institute was in a state of frantic operation.
but!
All this is not in vain.
Because, every day, they have new research results emerging.
After three days of research and observation.
They found that bile acids can not only dissolve the lipids of gastric mucosal epithelial cells, but also change the permeability of the cells and destroy the stability of the cells.
This discovery immediately excited everyone.
This means that they may actually have found the password.
They may be able to fill in the gaps in this subject!
Likewise, James Harken was extremely excited.
The deputy director on the side couldn't help but ask:
"James, you are really a genius!"
"How could you come up with this idea?"
"Amazing!"
"incredible!"
Other people in charge also nodded: "Yes!"
"I feel that this time, we may have a great result!"
"Maybe you can even win a small prize!"
Another professor on the side also smiled bitterly:
"I really didn't expect that the data that was once put aside can now be put to great use!"
"To be honest, I'm ready to throw it away!"
"Ha ha……"
"Fortunately I didn't throw it away, otherwise I might have become a sinner!"
"By the way, James, this trip to China has made you gain so much?"
"What happened?"
James Hacken suddenly smiled and said: "Erhe Hotel!"
"I met a strange man!"
"He gave me too many pointers."
"Besides, their research is definitely ahead of ours."
"The gap may just be because we are better at speaking with modern ideas."
"But others are better at using curative effects."
"hehe……"
"Traditional Chinese medicine is more magical than we imagined!"
"Don't slack off, everyone."
"Hurry up, I want to let the world see this new achievement as soon as possible."
At this time, although everyone was a little curious about what happened to the director of the institute in China.
But... right now, is there anything more exciting than researching new results?
gradually!
One after another, the latest studies are beginning to appear.
Bile reflux can also inhibit the activity of NO enzyme and cellular sodium-hydrogen exchange, causing intracellular DNA damage, causing cell apoptosis and inducing cell mutations.
Moreover, bile acids can also promote reverse diffusion of H+, stimulate mast cells to release histamine, stimulate gastric acid secretion, and further aggravate the inflammatory response.
…
then!
soon!
A paper was published directly in the journal "Tumor Discovery".
When this journal article appeared, it immediately caused an uproar.
"Tumor Discovery" itself has a very high impact factor, reaching 28.66 points.
Therefore, people who pay attention to tumor research cannot avoid such a journal.
but……
When they saw the latest paper, they were dumbfounded.
"Research on the effect of bile reflux on gastric mucosal intestinal metaplasia from the perspective of liver treatment"
This journal, which has a strong Chinese traditional medicine style, immediately attracted the attention of many people after it was published.
Originally... everyone just thought it was a gimmick journal.
But!
This article happened to be printed on the cover, and the first author turned out to be "James Hacken".
Suddenly, more and more people began to pay attention to this paper.
…
And this time!
Naturally, many people in China also discovered this article.
Shao Yanfang, the head of the Oncology Branch of the Association of Traditional Chinese Medicine Physicians, was immediately excited after reading this article!
Because this article happens to be triggered by the theory of traditional Chinese medicine, which conducts new theoretical research on chronic atrophic gastritis and intestinal metaplasia of the gastric mucosa.
no doubt!
This is a standard answer for the modernization of traditional Chinese medicine.
If the modernization of traditional Chinese medicine wants to develop, there is no doubt that what it needs is a direction.
And this time!
They actually saw this direction from abroad.
Although Shao Yanfang blushed a little, he was also very excited.
However, at this time, this is an office.
Shao Yanfang looked at everyone with a smile: "In this tumor forum, we focus on understanding and thinking about this article."
"This is a good direction!"
"Professor James is truly a leader in this field."
Others also nodded: "That's right!"
“This article is so well written!”
"Just in time, the meeting will start the day after tomorrow. We can prepare for it and have a good discussion then."
At this time, an expert on the side suddenly smiled and said:
"By the way, Professor Yu."
"I heard that this time Professor James Hacken came to China and personally visited your China-Japan Friendship Hospital!"
"I even had a good conversation with you!"
"This...isn't this the thought you gave?"
When Yu Jinhua heard this, his face suddenly felt filled with glory.
He smiled ambiguously and said, "Don't dare!"
"Just a simple exchange."
"Professor James is of high standard and has good understanding."
"I...I just had a casual chat."
Yu Jinhua felt as if his fortune was in a good direction, and such a good thing had been bumped into him.
At this time, Shao Yanfang suddenly said with a smile: "How about..."
"Director Yu, you will be the speaker on this article this time!"
"After all, you may be credited with this paper."
"It's more appropriate for you to tell me!"
Yu Jinhua suddenly felt excited.
Looking at the eyes of everyone around him, Yu Jinhua felt an unprecedented honor.
And at this time.
Shao Yanfang continued to ask: "By the way, have all the invitations been sent out?"
"Don't miss it."
"We in traditional Chinese medicine oncology are weak and weak, so what we need is a kind of unity."
"This time, doesn't it happen to show that we still have a chance?"
When everyone around them heard this, they nodded immediately.
…
And this time!
Chen Nan finally received an invitation letter from the Traditional Chinese Medicine Oncology Association.
Invite him to a discussion meeting in two days' time.
The day after tomorrow is Saturday, and Chen Nan is fine, so he can go take a look.
but……
He didn't expect that this James Hacken was really good, and he actually tinkered with it to produce a paper.
This result is indeed good!
The key is that James Hacken also wrote "CN: nan-chen" on the name of the corresponding author, the instructor.
This is no ordinary honor.
However, Chen Nan didn't mind, and just smiled and called James Hacken:
"Congratulations, Professor James Harken."
After James received Chen Nan's call, his excitement was beyond words: "Haha, dear Chen!"
“Thank you so much!”
"real!"
"I kind of miss that table of food now."
"Erhe Restaurant, right? I will definitely eat more next time."
Chen Nan smiled: "Yeah!"
"Right, let's get back to business."
"I have an article here that I might need you to post."
When James Hacken heard this, he laughed quickly: "Such a simple thing, no problem."
Chen Nan added: "It's from Chinese medicine!"
"Clinical trials on the treatment of intestinal metaplasia by traditional Chinese medicine, right?"
James hesitated: "Others may not be able to."
"but……"
"you can!"
"Send me the article."
"After I read it and revise it, I'll show it to you. If there are no problems, I'll make the draft."
When Chen Nan heard this, he was immediately happy: "Thank you very much, Professor James!"
James shook his head: "No, Chen, we are friends!"
"Also a partner."
"If you say this, you are out of touch."
The article Chen Nan sent to the other party was written by Mi Lei.
In fact, from a novelty point of view, there is nothing wrong with this article.
If it is published, it may be a great opportunity in life for Mi Lei who is far away in Shanxi Province.
…
ps: Thanks to the "Coffee Demon King" for the 11,000 reward, thank you.
Alas, my condition is not very good, I wrote 7,000 words in one day.
I still have a fever, and I didn't sleep from one o'clock to morning last night.