The World Symposium on Inflammatory Bowel Diseases was officially held.
This seminar attracted a lot of attention. As a key project of the World Health Organization, the main topic of this meeting is only one "Crohn's disease."
Therefore, even before the conference was held, it attracted a large group of professional media journals and reporters.
When Chen Nan showed up with Zhao Jianyong, Ning Wu and Xu Bing.
Soon a group of media reporters gathered around.
In the past, Chen Nan would basically avoid interviews with reporters, but this time, he stopped.
When the reporters saw this, they suddenly felt excited and quickly raised their microphones and cameras to face Chen Nan.
"Hello, Professor Chen, I am a reporter from the British "Medical Frontier". This time, your research on the treatment of Crohn's disease published in "Medical Forum" has achieved significant results.
The World Research Center for Inflammatory Bowel Disease has made an exception by inviting you to attend this conference, but your research has been rejected by many journals around the world and considered to be sensationalism. What do you think?"
"It's just that you don't agree!"
Chen Nan seemed to be surrounded by such voices for a moment.
…
When Yan Jiaheng and others saw this scene, they were dumbfounded.
When he opened the latest issue, he was completely stunned.
Kovacs also nodded, turned on the computer, and logged into the website of "Gene Health Research", a journal with high academic influence.
"Moreover, the theory of traditional Chinese medicine is a philosophical viewpoint and cannot help the development of medicine, let alone explore the specific causes of patients' illnesses."
When the reporters behind saw this scene, they couldn't help but feel sad.
"Indeed, any drug has side effects and adverse reactions, as long as they are controlled within a reasonable range, it will be fine!"
"That's a really funny question!"
"Then if the adverse reactions are so high in three years and accompanied by increasing drug resistance, what should the patient's follow-up treatment be?"
No matter what kind of medicine, there are pharmaceutical companies, and these pharmaceutical companies spend a lot of money every year to support scientific research and train experts. These people are the medical spokespersons of the pharmaceutical companies.
"but……"
With this start, future research will definitely speed up.
But does Chen Nan care?
"Okay, that's good. Let's discuss the treatment plan from Professor Chen Nan."
"In contrast, although Kampo medicine has not, it has made significant progress in the field of clear treatment of diseases."
Yan Jiaheng, Zhang Wu and Zhao Xiangpeng were not far away at this time.
At this time, other people also stood up and expressed their opinions.
Through genetic testing, a large number of patients have the rare primary immunodeficiency disease X-linked lymphoproliferative disease type 2 (XLP-2). Their hemophagocytic syndrome and refractory Crohn's disease are both caused by this causative gene.
Caused by mutation.
When Yan Jiaheng saw this scene, he fell into deep thought.
"Well, excuse me!"
However, after the Edo period, Dutch and German scholars introduced Western medicine to Japan, which dealt a serious blow to later generations.
"I knew it would be like this..."
"I just didn't finish what I said."
These are all valuable negative reviews.
Therefore, people are still accustomed to refer to Japanese traditional Chinese medicine as "Kampo" medicine; and Kampo medicine has always emphasized prescriptions and neglected medical theory, and it still adheres to the "correlation theory of prescriptions and syndromes".
“Mainly from three perspectives: disease progression, maintaining remission, and preventing complications.”
I also have unrealistic expectations for Chinese medicine.
"The main treatment measures are also 1. General treatment; 2. Drug treatment; 3. Surgical treatment."
…
Because isn't this scene exactly what Chen Nan said before going there?
"We will only respect the efficacy and patients, thank you."
But why did Chen Nan insist on going?
"Professor Chen is right!"
Before he could speak, another reporter soon started to attack him.
How could he speak for Chen Nan?
This thought made Yan Jiaheng couldn't help but shiver, and he quickly shook his head, not thinking about this problem.
As soon as this report came out, domestic netizens became excited.
But those who came to this meeting were all industry leaders, and they all had a say in inflammatory bowel disease.
"The theory of traditional Chinese medicine is originally derived from philosophy. It is not science, and it cannot conduct innovative research on the world and diseases."
His appearance immediately made many people present frown slightly.
I couldn't help being stunned!
"Sorry, that's only part of it!"
This video is exactly what Chen Nan was interviewing just now. Kovac patiently watched it without making any comments.
The former is what "Han Fang" calls the Later School, and the latter is what "Han Fang" calls the Ancient Fang School.
"At this meeting, we focus on discussing and exploring the current mainstream treatment options for Crohn's disease."
"As for the animal experiment results, there is no analysis of the specific ingredients of the drug. There is no reasonable explanation for the safety, effectiveness, and specific therapeutic rate."
"Support, whether it is effective or not, can the patient still not know?"
This photo was also published online along with the domestic media.
"Professor Chen, is your current attitude the same as yours towards patients?"
The one who spoke was Traore. He glanced at Chen Nan and continued:
"Our association has made an official announcement about Chen Nan's research, providing advice and warnings to patients."
Chen Nan also stood up.
Chen Nan said with a serious face: "It is very scientific to use a discipline that has been developed for more than a hundred years to deny a medical discipline that has existed for thousands of years."
At this time, someone else stood up and said:
"This is quibbling!"
After hearing Chen Nan's words, everyone below started talking quietly.
And just when everyone kept standing up and praising him.
He had actually thought of this situation.
There are two tendencies in Japanese Kampo medicine: tracing back to the ancestral lineage and leaving the ancestral lineage.
"You have no right to say such irresponsible words."
His back was photographed by countless people.
"What did I say..."
"I think this plan is good and can complement each other."
"We have data from animal experiments, and we also have analysis of clinical effects."
During this period, he investigated a large number of retrospective data studies, and this result is obviously correct.
"Third, immunosuppressive drugs. I don't think this drug conforms to the logic of normal drug response. It has caused secondary damage, reducing WBC cells significantly, inducing pancreatitis, and leading to severe liver damage."
The later schools are actually more in line with our domestic form of traditional Chinese medicine. They transcended the stage of empirical absorption of the ancient prescription school, traced back to the "Nei Jing", adhered to the medical tradition, paid attention to the guiding role of theory in clinical practice, and contributed to the comprehensive spread of traditional Chinese medicine in Japan.
It played a certain role in promoting the Japaneseization of traditional Chinese medicine.
"What a heroic figure."
…
The scene was completely silent.
"I do not endorse such therapy. It is an act that violates the patient's right to know."
Chen Nan himself never thought that such a thing would happen.
So, soon another reporter said: "Professor Chen, is your answer telling everyone that you have no confidence in your own research?"
"We conducted a study on 3,120 patients in the past three years, showing the effect of triple therapy, with a higher three-year remission maintenance rate and lower adverse reactions."
…
It can be said that their goal has been achieved.
Kovacs was born in Switzerland, but did not grow up in the same country. His special growth experience made Kovacs very knowledgeable about global ethnic medicine.
Moreover, many of their drugs have entered the world market.
Zhao Xiangpeng on the side was even more surprised.
Gradually, more and more people began to come forward and express their support.
Where is this?
He looked at everyone with deep eyes and said:
In fact, the so-called Ancient Prescription School only advocates paying attention to ancient prescriptions from the Han and Tang Dynasties; the so-called "Single Respect for Zhang Zhongjing" advocates using more prescriptions from "Treatise on Febrile Diseases" and "Synopses of the Golden Chamber" for clinical symptoms.
"To this end, I contacted Russian Food and Drug and investigated a large amount of data. I can only explain one thing, this data is representative."
Yan Jiaheng knew it at this time.
And at this time.
Because Chen Nan's answer can easily cause controversy.
Chen Nan smiled: "I do not deny that traditional Chinese medicine has side effects, nor do I deny that it causes liver and kidney damage."
"Welcome everyone to attend this seminar. It is very easy to have a research discussion on the topic of inflammatory bowel disease: Crohn's disease here!"
Obviously, this answer will not satisfy everyone.
After all, the topic raised by Chen Nan is too controversial.
It received a lot of bad reviews.
As Chen Nan walked forward step by step, pairs of eyes around him looked at him with a bit of hostility.
…
Then……
Chen Nan glanced at the logo on the other party's microphone, and then said: "I think Frontiers of Medicine is a journal with the ability to judge. For this matter, it doesn't matter what I think, what matters is the patient."
What do you think?"
“Based on the theory of traditional Chinese medicine, tracking Crohn’s disease gene testing finds genetic defects…”
He always feels...
And Kovac's expression on the stage gradually changed from surprise at the beginning to surprise, and then excitement!
It can be said that the value of this article far exceeds all the content of the meeting just now!
Originally, neither the treatment nor the cause of Crohn's disease could be found at all.
"Triple therapy increases the drug burden and has a significant three-year maintenance effect on patients, but... it increases the serious damage to liver and kidney function. According to a retrospective study, the probability of triple therapy inducing other diseases within three years is 29.33%. This is
Is this a normal adverse reaction?”
"That's right, Professor Chen, we respect you, but you don't respect our medicine."
"I knew..."
Kovacs was about to speak.
At this moment, a reporter suddenly spoke.
And soon, in addition to anti-TNF preparations, experts from other pharmaceutical companies also began to stand up for their company's new drugs.
Chen Nan buttoned up his suit, raised his head, straightened his chest, and strode forward.
At this time, Chen Nan said to Kovacs on the rostrum:
"Mr. Kovacs, can you use your computer to open the latest issue of the journal "Gene Health Research"."
but……
This is only possible unless this person has made outstanding contributions in this field.
"What a coincidence, among the 42 patients in my clinic, less than 3% have liver and kidney damage, and there is only one patient."
More and more people are joining it.
""Professor Chen Nan went alone to participate in the World Crohn's Disease Symposium"
The impact factor is as high as 20 points.
"Then I have a question. Crohn's disease is a recurring disease that cannot be cured and may even require lifelong medication."
"Based on the theory of traditional Chinese medicine and the five movements and six qi, the analysis of the triggering factors of Crohn's disease has resulted in a substantial breakthrough and progress!"
but!
He kept looking at Chen Nan.
"Maintenance treatment with amino acid salicylic acid preparations, combined with glucocorticoids to relieve symptoms during the active phase, and immunosuppressants to reduce immune responses."
As soon as Chen Nan said these words, there was a lot of discussion on the spot.
As soon as these words came out, there was a lot of discussion in the audience.
But……
"Hello, Professor Chen, we are reporters from the "Tokyo Medical News". After reading "Medical Forum", Professor Yoshikatsuki thought it was a sensational stunt. As a master of Kampo medicine, Mr. Yoshikatsuki is internationally renowned. He
After analyzing your treatment plan, I don’t think highly of you.”
No one spoke.
I didn't expect that once I came to Japan, I would receive so many negative reviews without even realizing it.
"I still have papers here."
He hoped that Chen Nan could make new discoveries to refute these capitals.
At this time, the reporters behind saw it and almost jumped up with excitement.
…
There are also more and more voices opposing Chen Nan.
"First of all, I severely accuse and criticize Chen Nan's denial of Kampo medicine."
But behind him, there was a sound of abuse.
I am very "satisfied" with Chen Nan's answer.
"First of all, Japan does not have independent medicine. The so-called Kampo medicine is a study of our traditional Chinese medicine. My denial of you does not mean that I deny traditional Chinese medicine. You cannot represent traditional Chinese medicine."
In fact, supporting triple therapy is supporting their academic philosophy, and it is also supporting the interests of their affiliated pharmaceutical companies.
"We are the author of "Latest Advances in Intestinal Inflammatory Diseases" in the United States. This article published in "Medical Forum" attracted the attention of many patients and also brought hope to everyone."
Because the character on the cover looks so familiar, isn't it... Chen Nan?!
At this time, after the cover was displayed on the projector, the whole audience was in an uproar.
Seeing Chen Nan drowning in the criticism and accusations, Yan Jiaheng was even a little happy.
Zhao Xiangpeng stayed out of the incident, as if watching the fun.
He muttered quietly to himself.
"Dr. Chen, fuck him, don't be a coward!"
"I don't think so!"
“Worth encouraging!”
Of course I care...
I don't know what to say either.
The so-called triple therapy.
"That's right, if you use Anji salicylic acid preparation alone, the effect on patients is average, and hormones can supplement this. Hormone therapy can easily cause tolerance and dependence, and it can be combined with immunosuppressants. The combination of these three is not
It’s as simple as 1+1=2, but it has a significant change in efficacy.”
Li Muhai and Qin Shiming were also paying attention to this matter at this time.
Good thing!
…
Then he handed over the video taken by his mobile phone.
"How can he alone compete with the forces of capital?"
Even in the subsequent development after the Meiji Restoration.
How did Chen Nan get on the cover of "Gene Health Research"?
Chen Nan's words were obviously full of ridicule, and the atmosphere at the scene suddenly soared.
And soon!
Ji Yishou also stood up:
It is conceivable that if triple therapy loses the market, what will it mean?
it goes without saying!
…”
Chen Nan's discovery of the XIAP-linked apoptosis inhibitory protein is definitely a milestone in Crohn's disease research!
When Chen Nan saw this, he said seriously:
"We have been going for decades for this, and you mix your own prescriptions. I don't think you have the ability to conduct safety analysis."
After a while, seeing that he couldn't come up with anything new, he said.
“After conducting a retrospective study, I analyzed the liver and kidney functions of 1,200 patients who had long-term use of salicylic acid preparations. For patients who took salicylic acid preparations alone for one year, the probability of liver and kidney function changes was 22.5%, while under triple therapy,
The one-year change rate is 47.3%, which is a terrible number!”
"Compared to China, our Japanese herbal medicine export rate ranks first in the world, and we also occupy a leading position in botanical medicine research."
…
"His plan adopts a combination of internal and external treatment, and uses traditional Chinese medicine for oral administration and Chinese medicine enema/external application for clinical treatment. Animal experiment data shows..."
What an honor is this?
Generally speaking, academic journal covers rarely include character covers.
This is one of the differences between Chinese and Western medicine.
"Although there are tens of thousands of people, I am going!"
Nowadays, in Japanese Kampo medicine, the ancient herbal school occupies an absolutely dominant position.
Kovac walked towards the rostrum. The 58-year-old now had white hair and wore a pair of black-rimmed glasses. He looked a little thin, but his eyes were shining with a bit of brilliance.
a long time……
Only Yan Jiaheng was sitting there...with eyes blank...
Lost!
In China, Li Muhai, who was watching the live broadcast, frowned more and more.
…
"Secondly, I have a lot of doubts about your treatment plan for Crohn's disease. For proprietary medicines like Kampo, which have undergone extensive data research, we have conducted a large number of safety analyzes to ensure the relevant efficacy of the medicine."
It can be said that Chen Nan's discovery is definitely an indelible and glorious milestone in the history of the development of Crohn's disease.
"Well, here's my opinion about triple therapy."
"His energy alone is too small."
Wherever there is controversy, there is news.
"Yes, Kampo medicine is not fucking Chinese medicine, and it does not represent Chinese medicine. They are not worthy of evaluating Chinese medicine!"
They just put Chen Nan in the spotlight of public opinion.
Since traditional Chinese medicines are not labeled, they cannot be used unless problems arise.
As soon as these words came out!
Suddenly everyone looked at Chen Nan.
"And I also don't think that traditional Chinese medicine is orthodox. Medicine is global and does not distinguish between national boundaries. Kampo medicine is where we absorb the essence and remove the dross to obtain the essence."
Zhao Jianyong did not follow him into the venue. He did not have a ticket, so he and Xu Bing could only wait at the door.
And there are a few words marked at the end: "Dr. Chen, don't be a coward!"
A medium-sized venue that can accommodate more than 300 people.
"Traditional Chinese medicine has been around for thousands of years and may have certain curative effects, but... where is the value you create? Or... I don't think that traditional Chinese medicine can make any creative discoveries about Crohn's disease."
The first ones to jump out are these pharmaceutical companies.
"What a pity!"
And at this time...
seem……
"Well, we did a real-world study last year on 522 patients and found that triple therapy, with immunosuppressants using anti-TNF agents, can significantly reduce the risk of intestinal stenosis, which prevents the development of the disease..."
Here, suddenly a person said something in Kovacs' ear.
"We support you!"
Traore and other people who had the strongest opposition to Chen Nan just now were completely dumbfounded.
…
After seeing this scene, Zhao Xiangpeng smiled: "This Chen Nan is really good at building momentum."
It seems that as long as the adverse reactions are labeled, it can be put on the market. Even if the patient has a problem, it is because the drug reacts normally.
"I hope he can perform well this time."
Before he finished speaking, someone quickly stood up.
to be honest!
He had already anticipated this situation.
Chen Nan didn't wait for the other party to finish speaking, stood up directly and said:
"In that case!"
"You say that TCM theory is philosophy and cannot make substantial progress in medicine!"
"I just heard that you don't agree with my point of view and say that there are problems with the safety of my drugs."
Kovacs also sighed a little.
"Your behavior is not only disrespectful to medicine, but also disrespectful to patients..."
The applause quickly spread.
When Kovacs opened the cover and entered the text of the paper, the scene was completely silent. No one spoke. Everyone looked at the article.
You must know that Ji Ishou is absolutely authoritative in the field of Kampo medicine. Even the current "Kampo Medicine User Manual" was produced by Ji Ishou.
This research at this time is undoubtedly a loud and epoch-making clarion call for counterattack.
The Yoshie family is absolutely authoritative in the field of Japanese Kampo medicine.
"First are the diagnostic criteria for Crohn's disease."
I definitely lost.
At this time, Chen Nan suddenly stood up and said to everyone:
It is a pharmaceutical dumping point.
"Finally, Chinese medicine is China's precious wealth, and you are not qualified to apply for a patent."
And this time...
After hearing this, Chen Nan said with a serious face:
"Sorry, Kampo is not a traditional Chinese medicine, he is not qualified!"
Chen Nan's words can be said to directly deny Ji Yishou.
Chen Nan's words made the other reporter look a little ugly.
At this time, reporters from China excitedly took such a photo.
Chen Nan said directly: "This attitude is directed at you."
"There is a mutation in the X-linked inhibitor of apoptosis protein (XIAP) gene on the X chromosome. This pathogenic gene mutation is the "culprit" of severe Crohn's disease...
Chen Nan's medical statistics is absolutely top-notch.
…
"Professor Chen, come on!"
For a moment, everyone in the audience frowned.
"According to current scientific research, Crohn's disease research currently lacks a gold standard for diagnosis. It can only be comprehensively analyzed from clinical manifestations, endoscopy, imaging, and histopathology."
Among them is Ji Yishou.
This time, I shouldn't have come.
After they saw the photos sent from the front.
All of a sudden, more and more people online got involved.
"What you recognize is the data under your own rules. I'm sorry, there is no need for me to ignore patients in order to satisfy you!"
But!
"The first option discussed first is the triple therapy proposed by the American Crohn's Disease Research Group."
In other words, he felt that Chen Nan dared to come to this meeting this time, so he was obviously prepared.
At this time, many people also noticed Chen Nan participating in the interview.
"Professor Chen, you are disrespecting our great Kampo medicine and denying the Jiyi family!"
Chen Nan's words immediately caused many people to fall into deep thought, but... they soon aroused the disgust of everyone around them.
"What do you think about this?"
"Professor Chen, the American professional association is now revising the terms of your article, not recommending patients to receive TCM treatment, and even questioning the efficacy and safety of TCM. What do you think?"
Kovacs watched quietly and said nothing.
He is also the person who has repeatedly proposed that ethnic medicine be included in world medical research projects.
After Chen Nan heard what the other party said, instead of being angry, he laughed.
The audience soon fell into controversy.
After saying that, Chen Nan stood up directly and left the reporter.
"Dr. Chen, don't be afraid!"
He clapped excitedly.
This domineering and stern look and the back view are enough to explain everything.
The ancient faction directly suppressed the later generations, leaving no room for survival.
The representative figure of the ancient prescriptions school is Yoshitake Tōdō. As the most famous Kampo doctor in Japan in the 17th century, Yoshitake Tōdō can be said to have promoted the development of Kampo medicine in Japan.
ps: Sorry for the long wait.
"This is worthless!"
"I believe that since the data I have here are like this, other countries will be the same."
Although, this XIAP-linked apoptosis inhibitory protein is only one kind.
but!
Three generations of the Yan family have all suffered huge losses at the hands of Chen Nan.
The conference venue is not big.
Kovacs arrived at the venue early and sat down quietly in the first row under the rostrum, flipping through the information in his hands and waiting for the meeting to start.
This is impossible, absolutely impossible!
"I think the progression of the patient's Crohn's disease is more fatal than the adverse drug reactions."
"According to everyone's opinion, traditional Chinese medicine is unqualified because there is no safety analysis, but your medicine is qualified because you marked it as unqualified?"
[Ding! Congratulations, you have received a negative review from Ji Yishou, the negative review level is: medium! 】
Therefore, when he walked into the conference center, he didn't know how many pairs of eyes looked at him.
"The development of medicine is always in stages. Three years ago, anti-TNF therapy was not available, but now it is available, enriching the treatment system, which shows that we are on the right track."
But how old is Chen Nan, and what great contributions can he make?
This is obviously unrealistic!
…
“So we don’t approve of this research!”
"However, as far as I know, your treatment methods and plans lack scientific theoretical basis, and there is a lack of research on safety. Is this behavior an irresponsible behavior towards the patient?"
"The next thing I want to say is..."
And that's not all.
After Yan Jiaheng suffered several losses from Chen Nan, he knew that Chen Nan was definitely not the kind of person who did not make preparations.
"This makes it more difficult for us to treat Crohn's disease early."
The reporter's voice was a little more questioning.
Chen Nan smiled slightly.
Zhang Wu and other loudmouths were speechless for a long time.
The speaker was Traore, a committee member of the Inflammatory Bowel Disease Research Center, who is also the vice president of the American Inflammatory Bowel Disease Association.
Chen Nan's interview has been seen by many people.
"Yes, this is sophistry."
The article described in detail what Chen Nan encountered during the interview and what Chen Nan may have encountered during the meeting this time.
However, at this moment, he had no intention of worrying about this matter, because the meeting was about to begin.
"Come on Dr. Chen!"
“Everyone speaks freely!”
"I would like to ask you, is it necessary to adhere to this kind of therapy?"
So far, traditional Chinese medicine preparations have not entered the international market, and the attitude of the FDA shows that the drug ingredients are inaccurate and the safety analysis is unqualified.
"First of all, the theory of traditional Chinese medicine is a philosophy, not medicine, and has no significance in clinical diagnosis and treatment."
At this time, Traore stood up.
"According to Professor Chen's understanding, don't Chinese medicines have side effects?"
Will Chen Nan really lose so easily?
That’s right!
XIAP gene mutations induce inflammatory bowel disease through defects in innate immune function of intestinal immune cells.
Li Muhai couldn't help but sigh: "This kid...has already established his momentum."
"Okay, what do you think?"
"Secondly, Kampo medicine is the beginning of a detour for traditional Chinese medicine. I think you should go back and seriously examine your own medicine instead of questioning me."
"That's right, who said they are right? My daughter is hospitalized in Professor Chen Nan's hospital, and her symptoms are relieved now. What is there to say?"
He overestimated Chen Nan.
Continuously, more and more people stood up and spoke.
No one expected that Chen Nan would actually discover the specific cause of Crohn's disease.
And this scene has also spread to the country!
There was a dead silence at first, and then, someone started to applaud.
"Currently, the purpose and effectiveness of Crohn's disease treatment are based on the guidelines given by our inflammatory bowel disease last year."
"The second point is that glucocorticoids cause hormone dependence. Normal patients take glucocorticoids alone and the dosage is significantly reduced. However, triple therapy is more effective in hormonal treatment. Long-term use will lead to aggravation of inflammatory reactions and retaliatory growth.
"
Sure enough, with Chen Nan's denial of Kampo medicine and Yoshikuri Mori, a group of Japanese journalists couldn't sit still and stood up to oppose Chen Nan.
As soon as these words came out, the surrounding Japanese reporters immediately went into a frenzy.
Gradually...
For example, anti-TNF immune preparations come from Elevi, the largest biologics company in the United States.
This is an absolute relationship driven by interests.
Yan Jiaheng and others sitting in the back did not express any opinions from beginning to end.
Time, at this moment, is extremely slow.
These reporters are not fuel-efficient lamps.
"Traditional Chinese medicine lacks big data analysis, and has many chemical compounds, which can cause serious harm to patients..."
In contrast, the ancient school of medicine, represented by Jiyi Dongdong, gradually developed into the mainstream of Han medicine after Western medicine was introduced to Japan, and became a distorted Japanese "Chinese medicine".
"Although aminosalicylic acid preparations can be effective for mild patients,... long-term use will cause a lot of liver and kidney toxicity."
Elevit is well-known in the fields of rheumatology, oncology, neuroscience and other fields.
Therefore, when Mitchell published in "Medical Forum" about Chen Nan's treatment plan, it caused an uproar.
What is the Ancient Fang Sect?
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