Generally, the first phase of clinical trials is mainly to test human safety and tolerability, the second phase is to test safety and basic efficacy, and the third phase is based on the second phase to expand sample testing.
There are not many sample requirements for the first and second phases, and they generally proceed very quickly.
Phase II and III clinical trials are sometimes connected together in order to advance the trials faster.
Now Shennong Pharmaceutical has completed the first phase of clinical trials and is recruiting more volunteers to participate in the second phase and even the next phase three trials.
This can take as little as one or two months and as much as two or three years.
After the official online account of Shennong Medicine announced the recruitment of volunteers, many people came to Meicheng Hospital.
These volunteers are basically for compensation.
Of course, some people are just lucky, hoping that this anti-cancer drug test can not only cure their cancer, but also get a compensation, which is simply killing two birds with one stone.
Two weeks later, Fang Mu also completed the second phase of clinical trials, and Xu Li also came to Meicheng Hospital of Traditional Chinese Medicine to inspect the situation.
"Boss, our phase 2 trial data is out. You see, the effect is unexpectedly good. Currently, except for 400 subjects, we only found one person who had other diseases before that caused certain side effects. The others
This doesn’t happen to anyone.”
"The drug takes effect half an hour after the patient takes it, and it can also be taken orally to achieve the same effect as intravenous injection. This anti-cancer drug you have come up with is really powerful!"
"This is a very excellent anti-cancer drug that can inhibit the spread of cancer cells and prevent the gene production of cancer cells. It has excellent therapeutic effects on the lungs, stomach, liver, and pancreas. The next three clinical phases are
The trial went so smoothly, so this drug will definitely benefit people across the country."
Fang Mu seemed very excited. Although he accepted the research and development work of this anti-cancer drug, the information and prescriptions for this anti-cancer drug came from Xu Li.
Xu Li couldn't help but nod after hearing this. He got the prescription and technology of this anti-cancer drug from the space of the Science and Technology Library. Strictly speaking, it is not his, but it is a good thing to be able to use it to benefit the people.
"That's good. How are the preparations for the third phase of clinical trials?"
"Enough people have been recruited so far, but the next cost may be even greater, otherwise..."
Fang Mu was a little worried.
"It doesn't matter. I'll let Suiren Technology transfer the compensation and reimbursement from the hospital. You can also try to find as many volunteers as possible to make the experiment rigorous and accurate. In this way, maybe we can
It might be launched within half a year."
Xu Li interrupted him.
Fang Mu nodded, "Okay, I'll do it right away. I'll also prepare the application and approval matters early to avoid being in a hurry."
"Then we should try to do it as soon as possible. If it can really be done, the policy support of the national department for anti-cancer drugs will be quite large."
"I know this. When it is launched, I plan to introduce this anti-cancer drug into medical insurance, so that it can truly benefit the people."
If it seems that the price of special effects is too expensive, then it is not a blessing. And the risk of cancer in Long Country is as high as millions, which is a very huge number.
There are also many ordinary families among them, and among these ordinary families, who among them can afford prices like Pfizer’s?
It directly bankrupted our own company, so the set of drug prices in the West is not feasible in China.
And we need to develop anti-cancer drugs as soon as possible and then sell them on the market.
It is said that Suiren Technology has made some progress now, but it is still not enough. In addition to having a lot of people to feed, especially in technology research and development, we need to work harder.
And it seems that he is so eager to advance research and development not just to make a small amount of money, but also to compete with the vampire alliances in the West.
The successful development of 14nm and ultraviolet lithography machines has definitely touched their cake.
This group of people will definitely take the next step, so he needs to build a stronger fortress so that he can keep the enemy outside the wall and even reverse the situation at a critical moment.
This can be considered a proactive attack.
Then, under Fang Mu’s arrangement, the Phase III clinical trial work officially began.
Meicheng Hospital of Traditional Chinese Medicine
Liu Lili, female, 32 years old, terminal pancreatic cancer patient.
She has been treated in this hospital for some time. Since she was already in an advanced stage when she was discovered, the effect of the treatment was not good. She is now undergoing follow-up treatment.
Pancreatic cancer is a malignant tumor that occurs in the pancreas. It is highly malignant and generally difficult to diagnose and treat. It is also known as the "King of Cancers" and its 5-year survival rate is less than 100%. p>
It can be divided into ductal adenocarcinoma, special types of cancer of ductal origin, acinar cell carcinoma, small glandular carcinoma, large eosinophilic granular cell carcinoma, and small cell carcinoma.
Generally, the high-risk groups for this type of cancer are those over 50 years old.
There are many causes of this cancer. A family history of pancreatic cancer or multiple tumor suppressor genes. These mutations will increase the risk of pancreatic cancer. Diabetes and bad living habits may also lead to pancreatic cancer.
occurs.
Moreover, pancreatic cancer is very difficult to detect in its early stages, which also makes diagnosis difficult.
When the disease occurs, the abdomen will often hurt because the tumor continues to grow and compress the surrounding nerves and senses, causing obvious pain in the abdomen or back.
It can also lead to unexplained weight loss, nausea and other vomiting, which can also aggravate abdominal pain.
Therefore, high-risk groups like this can generally be screened regularly during physical examinations and undergo some CT or ultrasound examinations.
Of course, there are currently anti-cancer drugs for this type of medicine, but these anti-inflammatory drugs are expensive and sometimes have poor results due to the patient's physical condition and other issues.
Liu Lili is an ordinary college student and grandma who was preparing for the postgraduate entrance examination.
But he didn't expect to be diagnosed with such a disease, which really hit him hard.
Her parents came all the way from their hometown to stay with her and comfort her every day, but she knew that their parents were also crying secretly.
But she still faced it with a smile, and made a short video of her daily situation and posted it online, hoping to encourage more people.
Her smile and strength have gained many fans, who leave messages of encouragement every day.
Not long ago, the doctor told her that there was a trial drug for a clinical trial and asked him if she could participate. With a little hope of survival, she signed an agreement after negotiation with her parents and signed up for this clinical trial.
In addition, regarding her own clinical trial, he also obtained the consent of the doctors and decided to broadcast the entire process live.
Today, Liu Lili is holding her bald head with a smile.
She knows that it's okay to look sad all day long. If you look at it like this, it will make her fans even more disappointed. She is here to encourage people, not to use negative emotions to discourage them.
And with this group of kind-hearted fans, she felt that her heart felt a little warmer.
"Don't be afraid Lili, we will accompany you together!"
"Come on, be happy every day!"
"Go hard today and relax, I believe your illness will get better!"
Seeing the barrage in the live broadcast room, she couldn't help but shed two lines of tears, but they were not sad but moved.
"Thank you! You have always been talking to me! Today I signed up for a clinical trial of a special anti-cancer drug. I heard that it is very effective. No matter what, I will give it a try. I also believe in doctors!"
"Don't cry, come on! There is no obstacle in this world that you can't overcome!"
"Have faith, you will get better!"
...Fans left messages of comfort on the barrage..
Looking at this girl who is losing weight day by day, they also feel the same way.
After all, the human heart is made of flesh, not made of iron.
In the short video posted before, fans saw that this frail girl was taking a lot of medicine every day, but the effect was getting worse and worse, and her face became paler and paler.
Although they cannot experience this kind of pain, everyone's eyes are sharp and they can naturally see the changes in daily records.
Liu Lili looked at the live broadcast and continued chatting with her fans.
"Today, an old man in the same ward as me is also a terminal cancer patient, but he seems to be much better and his face is much rosier.
Before, he had trouble speaking and had to be helped to get in and out of the toilet, but these days he behaves like a normal person. He can chat with me freely and can walk by himself.
I just learned that he also participated in the drug trial, but he was a Phase II subject earlier than me, just two weeks earlier than me, so I believe that this anti-cancer drug is effective, and maybe by then I will
I can get out of bed and sing and dance for you."
Speaking of this, Liu Lili laughed.
"Is this true? You can recover so well after just two weeks of taking it?"
"Whose anti-cancer drug is this? The effect is so awesome!"
"If the live broadcast room hadn't been a hospital, I wouldn't have believed it."
Liu Lili answered, "I don't know that everyone doesn't believe it, so I chose to live broadcast the entire process of my drug trial so that everyone can see the changes in my condition every day.
I have been taking the medicine for the past two days, and I feel a lot better. My body is not so tired, and my mind is much clearer, so it is okay to chat with you for a long time today."
"That would be great. If taking this medicine is really effective, that would be good news."
"We also believe that you will get better. Don't forget to sing and dance for us when the time comes, and fulfill our own agreement!"
"By the way, Lili, are there any handsome or beautiful doctors in this hospital where you live? If so, don't forget to introduce us!"
Fans continued to comfort him, but they didn't quite believe what Lili said about the anti-cancer drug.
Although they are not professionals, they know that if there is such a magical medicine, then why does the country introduce so many imported medicines every year, and why do rich people go to foreign hospitals for treatment?
These are obvious.
But in order to cheer up Lili, fans in the live broadcast room also echoed and tried to change the topic.