Chapter 133: Large-scale scientific research seminar
For the academic circle in Shanxi Province, these days are very extraordinary.
A large-scale academic seminar jointly organized by Jinxi University of Traditional Chinese Medicine and 15 universities in western Shanxi Province was officially held!
This is a lecture on academic exchange and experience discussion. The speaker is Keao Deleps, deputy editor-in-chief from the world-class journal "cell". The other speakers are famous scientific research professors in Shanxi Province and the magazine's editor-in-chief.
It can be said that this is the largest academic seminar ever held in Shanxi Province.
This meeting attracted great attention from the Provincial Health and Family Planning Commission, the Provincial Department of Education, etc., and specially approved the Provincial Gymnasium.
Of course, one of the main reasons is that there are too many people attending the seminar and the general academic exhibition hall cannot accommodate them.
For a time, this meeting also attracted the attention of countless people from all over the country.
After all, in everyone's impression, Jinxi has always been a weak area for master's degrees and scientific research. Unexpectedly, the deputy editor of "Cell" was invited.
This matter is also a hot topic, attracting the participation of many academic enthusiasts and scientific researchers.
However, when everyone was paying attention to this matter, Bai Ye went to the hotel to study the data day and night.
This data is too complex and messy.
But……
This is not a bad thing, it can even be a good thing!
Why do you say that?
Because Bai Ye discovered that there are actually many core technologies hidden in it, and these technologies are unique to large foreign scientific research bases.
After two days of research, Bai Ye roughly figured out what these data were.
For some reason, Keao didn't explain clearly.
This is the entire process of research and development of a new drug.
This process took more than 3 years.
Perhaps the later clinical trials took longer, ten to eight years, although I don’t know why the subsequent data was lost.
But this process is already extremely precious.
It is a complete and mature new drug research and development system from the drug conception stage, to the preparation of new drugs, to the design of new drugs, the development and production of new drugs, and clinical trials.
This drug is very precious and is a molecularly targeted drug for the treatment of malignant tumors.
At present, the cause of tumors is still unclear, so this experiment is based on single-cell sequencing, which uses a single cell as a template for downstream second-generation sequencing research.
Currently, the most common single-cell sequencing is used in tumors.
After Bai Ye saw this sophisticated thing, he suddenly felt like his head was too big.
One of the most difficult directions in bioengineering is genetic engineering, and this experiment is precisely the first step in genetic engineering, which is the most cutting-edge scientific research direction in the world.
The development of second-generation sequencing technology has made people aware of the increasingly serious relationship between human diseases and genomic variation.
The occurrence of tumor diseases occurs precisely at the monoclonal level, making it very necessary to detect mutations at the nucleotide level of single cell nuclei.
The content of the first large part of the data is precisely to conduct a systematic analysis of the pre-implantation, prenatal, screened embryos, etc. during the implantation stage of this experiment.
Single-cell sequencing mainly involves two aspects: single-cell genome sequencing and transcriptome sequencing, which perform sequence analysis and comparison on the DNA and RNA of a single cell respectively, thereby revealing changes in the genome and transcriptome.
The first large-scale data mainly focuses on observation and observation of the transcription and translation processes of single cells.
Their experimental process mainly involves continuously cultivating single cells and then causing cancer under various external conditions. This process is within the scope of detection.
It is necessary to carefully observe a mutation in DNA and RNA during the transcription and translation processes.
Of course, this is an experimental process, but this is not Bai Ye's job. Bai Ye's job is to study data.
However, this kind of molecularly targeted drugs, especially those studied at the genetic level, are rare in China. There is insufficient experience and technology in this area. If this process is carefully sorted out, it will be a very valuable thing.
Through these observed data, the results are found.
Bai Ye's calculations went smoothly, initially smoothly.
In one day, Bai Ye got the results of the first part.
The mutation point has been found, and the mutation results are also very accurate.
However, what surprised Bai Ye was that there was a result at the end of this data!
At the end of the first stage, the results of the data analysis are written.
This result is exactly the same as Bai Ye's calculation.
This embarrassed Bai Ye.
Keao came back in the evening, looked at Bai Ye who looked confused, and asked what happened.
Bai Ye then said: "I calculated the results of the first part, but... I found that there is a summary in the ending below, and the other party's answer is exactly the same as what I calculated."
Keao seemed to know the result, frowning and asked: "Is there something wrong with the analysis of the first process?"
Bai Ye shook his head: "No, there is no problem! I can guarantee the first part of the data analysis results, there is no problem, and... what do you want me to calculate?"
As soon as Keao heard Bai Ye's words, he became a little restless and walked around the room without speaking.
After a long while, he seemed to be struggling and said: "Calculate the second part of the data, do it carefully, be sure to pay attention to every detail, and see if there are any problems. Remember... don't miss any clue..."
When speaking, Bai Ye felt that Ke Ao's voice, which was usually a bit sharp, was much hoarse!
What has actually happened?
Bai Ye spent the whole night thinking about this data.
There was no problem at all. I calculated it again and again, but the result was the same as the other party's.
Even the probabilities are exactly the same!
At dawn the next day, Bai Ye and Ke Ao had a buffet breakfast together. During the meal, Ke Ao looked a little depressed, probably because he didn't sleep well last night.
Before leaving, Keao hesitated to speak, but turned around and left again.
In the following time, Bai Ye ignored the purpose of the experiment and the records of the experimental methods.
After all, what is written above is not detailed. It only describes the method used to obtain a certain step, and then the data results. The core technology is not available at all.
So, just don’t bother!
Let's study the data carefully.
In this way, the speed is obviously accelerated.
In three days, Bai Ye calculated the second part and came up with the result...
Well, no surprise, the result is exactly the same as the other party's.
This is embarrassing...
This... you did nothing with yourself?
Calculate a bunch of results that are exactly the same as the answers?
If this were a test, Bai Ye would definitely be happy. After all, it was exactly the same as the correct answer, so why would he be unhappy?
But this was not an exam for him, and looking at Keao's state, Bai Ye felt that the purpose of him asking him to calculate was definitely not to verify the correctness of the answer!
Could it be...that he wanted a different result?
Today, Keao's lecture has ended. In the evening, everyone had a dinner to express their gratitude to the lecturers.