Chapter 154: Strategies for breaking the whole into pieces
The cross-cutting development of top disciplines in multiple fields, as well as the sponsorship of top biomedical groups, put mio in a good virtuous cycle.
At this time, in the research center of the MIO Research Institute, Enders was breathing calmly with a flushed face.
This is the fourth meeting since I received the article "BPFH Grading System for Experimental Rats" from Bai Ye of China, and every time the debate is lively or very heated.
Attending the meeting were more than 20 related project teams affiliated to the mio institute.
As the most authoritative organization in the field of experimental animals, MIO has established specialized scientific research groups for each indicator and field of experimental animals in order to have specialized personnel engaged in specialized work.
In this way, not only can multiple disciplines develop together, but they can also be integrated for comprehensive development.
Today's meeting is also about Bai Ye's "BPFH Grading System for Experimental Rats".
As the chief engineer in charge of animal experiments at Johnson & Johnson, Enders has long seen the merits of this article, especially the proposal of the bpfh score, which can be said to be a remarkable score in the entire field of animal experiments.
Enders took a deep breath and continued: "Everyone, today we are here to get a better conclusion, not to argue. I really think the ideas proposed in this article are worthy of our study."
At this time, a white man in his 50s with a serious face and thick eyebrows knitted together said solemnly: "Enders, I think you are a bit exaggerated. Do you know if you verify the score sheet?
How much work will all the projects require?”
"This requires more than twenty of our groups to conduct experiments at the same time, abandon all the research we are currently engaged in, and instead evaluate these scores that are likely to be meaningless. The time required is seven days. Do you know what this concept is?"
"To be very realistic, this is not something that a small number can afford. Do you think those pharmaceutical groups want money so much? They are just a bunch of vampires. Where can they have the extra money to do this ridiculous scoring test?"
Enders was a little angry. This white Makota was simply too selfish to be a scientific researcher!
However, MIO is a democratic and free institution, and dictatorship does not exist. However, as chairman, Enders has the privileges of the chairman, although this privilege is limited.
However, he was very interested in Bai Ye's bpfh score. This scoring method opened a new era in experimental mouse research. Once successful, there is no doubt that it will be a milestone in the development of mouse research.
After a long silence, Enders raised his head, his eyes were bright, and he said word by word: "I have decided that all groups will suspend all current projects and conduct a systematic review of the BPfH score to test the reliability of the "BPFH Grading System for Experimental Rats."
"
Karta was stunned!
He widened his eyes and said: "Enders, you are talking nonsense, do you know what you are talking about? Suspend the current research, do you know what research we are engaged in now?"
Enders snorted: "Oh? Of course I know. Have you been studying the research on matching stable mice? Haha, how many years have it been? Have there been any results? It has been five years since mice were matched to human gene stability.
Is it too much? Are we still stuck at that point with no way to move forward? So a one-week suspension shouldn’t have any impact, right? Maybe we can save some money.”
"Okay! You don't need to say it. I will use the privilege of Chairman MIO once. From now on, I will suspend the current research and verify the "BPFH Grading System for Experimental Rats"!"
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Bai Ye frowned and looked at Keao's data records in his notebook. These were all completed, but Bai Ye had a different idea in his mind.
Although he now knows why Keao and the others failed, how can he prove it?
How to prove the unique adaptability of km mice has caused the genetic sequence of mice to mutate, leading to a series of erroneous conclusions.
In fact, that drug does not inhibit the reproduction of tumor cells, but causes a purine mutation in the DNA and RNA sequences of mice during transcription and translation, resulting in a series of adaptive changes similar to evolution, and a wrong result was obtained.
in conclusion.
Bai Ye felt that a series of experiments should be conducted to prove the stability of the gene sequence of km mice.
If it is proven that a certain gene sequence of the km mouse is unstable, it can lead to mutation under specific conditions and produce specific adaptability.
This mutation makes mice unsuitable for animal experiments because they are too different from humans, and the conclusions drawn from the experiments are not applicable to humans.
Therefore, these km mice are not completely suitable for animal experiments on human drugs!
But how to conduct such an experiment?
This is not a simple control group experiment. It involves issues of genetic engineering. Once genetic engineering is involved, this issue cannot be solved with millions of dollars.
Because those genetic engineering instruments are very expensive, the experimental costs are very high. Not to mention Bai Ye, even the current Jinxi University of Traditional Chinese Medicine does not have such experimental conditions.
Is it just going to be delayed like this?
Bai Ye was a little reluctant, hey...it would be great if he had his own laboratory!
Thinking of this, Bai Ye was full of endless fantasies about his 500-square-meter laboratory.
It's a pity, 5 million is terrible!
We have to make money! Isn’t it just five million? Bai Ye is confident that when the feed is researched, five million will not be a big deal at all!
There have been too many messy things recently. Bai Ye is a bit messy. He can't take on so many things in the future, otherwise he really won't have enough energy.
Further genetic testing research on km mice has temporarily stalled.
Next, let’s get the feed matter settled first. Once the “BPFH Rating System for Experimental Rats” is released, it will definitely be a storm in the experimental animal world. By then, if you add fuel to the fire, you will definitely be able to use by-1 type feed.
Push it abroad!
Let foreigners also experience the traditional core technology of China.
We raise rats... we can actually be very professional.
Thinking of this, Bai Ye's thinking became clear, and his current work direction was also clear.
The assignments still have to be done, but instead of doing bpfh grading, we have to go into every small step and make specific comparisons.
For example, the measurement of a specific item of mouse experimental stability in the bpfh score is also possible!
That is to say, separate the indicators in the bpfh score and do them separately!
Compare Baiye's by-1 type feed with the imported feed on the market to culture mice to see which one has better results.
This is also a topic!
When the "BPFH Rating System for Experimental Rats" is released, I can combine these data through techniques. Wouldn't the combination be the so-called BPFH rating?
Besides, since I am the inventor of this score, I have naturally verified that my feed can effectively improve the score of bpfh.