Chapter 191: This will be a news that affects the world
The news about Naya Group spread instantly in the country and caused a heated discussion.
Everyone was talking about Naya Group's move at this moment.
"Let me go? Is it true or not, Naya Group has launched a new type of SHR? No, it can no longer be called SHR, it should be called a new type of essential hypertensive mouse!"
"Haha, is it true or not? It would be great if it was true. You don't have to be angry. Those stupid capitalists are making you jealous." Even scientists who were well-mannered in the past said swear words happily.
But while everyone was discussing it, Macalette, an expert from the European Gene Bank, was sitting in the office. Holding a cup of coffee in his hand, he said with a smile: "Pointer, don't worry, if the new shr really has such
If it’s easy, those Chinese people won’t make so many reservations.”
Pointer looked at the computer in silence, not knowing what he was thinking. He always felt that things were a little strange.
Tang Han understands that Naya Group and Longka have been competitors for a day or two. If the person who knows you best is not necessarily your friend, it is very likely that he is your opponent. Pointer agrees with this statement.
.
He felt that Tang Han was not the kind of person who bluffed. That man was very courageous. If he didn't do something, he would definitely go all out to do it.
This announcement was officially launched by Naya, and it must have been authorized by Tang Han.
In this case, this matter requires further research.
Thinking of this, he called the person in charge of the Asia region: "You should pay close attention to Naya's developments. If you have any news, please tell me immediately."
Macalette smelled the fragrant coffee, and he sneered a little at Point's caution.
If the new model of essential hypertension were so simple, their efforts would not have been so slow for so many years.
"Pointer, I think what you should do now is not to be cautious about Naya, but to defeat this lie! I think this is just a delaying tactic by the Naya group."
Pointer smiled: "I naturally believe in Mr. Wright's ability. In the field of genetic engineering, you may be the most professional. I will release new information now. The sales quantity of SHR in Asia will be limited in one month."
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After Zhang Hanlin saw Naya's announcement, he quickly dialed Tang Han's phone number. Now the two communicate frequently.
"Mr. Tang, has your company really developed a new type of essential hypertensive mouse?" Zhang Hanlin was still a little unsure.
Tang Han smiled: "Well, if there are no big problems, it might be true!"
Zhang Hanlin felt inspired when he heard Tang Han's personal confirmation!
"Beautiful! Give our countrymen a chance to breathe!"
Tang Han suddenly asked: "Aren't you surprised who did this?"
Zhang Hanlin was stunned: "Who can do something different? Naya Group is full of talents, I believe there are always geniuses!"
Tang Han laughed: "It was studied by Bai Ye."
After hearing this, Zhang Hanlin said lightly and asked, "Bai Ye went to your place?"
Tang Han was a little confused: "Aren't you surprised?"
Zhang Hanlin: "Surprised? If it was someone else who did it, maybe I should be surprised, but... as for Bai Ye, I should be used to it, otherwise I would have a heart attack. Now you are telling me that Bai Ye was nominated for the Nobel Prize, I
There won't be any fluctuation in my heart. How do you say that? Steady as a dog!"
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While everyone was paying attention to the news about essential hypertensive mice, Bai Ye finally wrote a paper on the unstable gene in km mice.
The name is: "Avenging those past experiments, the real culprit of deaths in clinical trials is actually unstable guanine"
He restored and written all the experimental data, and to be on the safe side, he also made several backup copies of the data.
The genes of this stable km mouse did not change much after removing the guanine. During this period, Bai Ye tried to remove which guanine base in the nucleic acid of embryonic cells.
But this kind of operation is no longer possible for him, because it is difficult for the base contained in the mouse embryo to undergo further changes without reaction.
Just like a defense mechanism, this base will only play its role when a series of reactions occur.
Bai Ye communicated this news with Dong Cunguang, but he also frowned and had no choice.
what to do?
I don’t know much about experts in the field of genetic engineering, right! Zhang Shulan.
This is a big shot who graduated from a world-class university. Maybe she can find a solution?
After Bai Ye called Zhang Shulan, he told her his findings. Zhang Shulan was silent for a while and suddenly said: "Come to the Institute of Bioengineering, Chinese Academy of Sciences, I will wait for you in the office."
After Zhang Shulan hung up the phone, although her words were calm, her heart was like a volcano erupting under the sea!
The news that Bai Ye brought to him was so shocking. The km mouse is recognized by the world as extremely stable and the most suitable mouse for human research and experiments.
But can this view be proven wrong?
If it's true...
The consequences are disastrous. This is not just a mouse problem. If it is proven that the instability of km mice does exist, then many previous experimental failures...and so many problems with marketed drugs...can all be explained.
So after understanding this problem, Zhang Shulan directly asked Bai Ye to come to the office. Bai Ye was not in a hurry, but she was fidgeting anxiously.
After Bai Ye arrived, the two of them closed the door directly. Bai Ye had already opened the prepared notebook, and all the data was recorded in it.
Zhang Shulan carefully looked at the data and experimental analysis results one by one, holding a piece of paper in her hand, and kept writing and drawing, hoping that Bai Ye had a problem in that link.
To be honest, she didn't want Bai Ye's conclusion to be true.
Because if this is true, it is very likely that the medical market will face a huge turbulence for a long time to come. This is not a good thing, and people's emotional panic is also a disaster.
However, after reading most of them, Zhang Shulan sighed, Fortunately... this kind of genetic instability only occurs in a few cases, and it is not easy to trigger.
Zhang Shulan looked at Bai Ye, a little curious: "How did you think of studying this?"
Bai Ye said: "This involves the previous research on a new drug. I published a paper in the magazine "Cell"..."
After Bai Ye told Keao's story, Zhang Shulan suddenly said with wide eyes:
"You're talking about the Mikasu-Tranli incident?"
Bai Ye was stunned: "Teacher Zhang, do you know?"
Zhang Shulan sighed: "Mikasu is the person who was nominated for the Nobel Prize. If he had not done that, it is very likely that the next Nobel Prize winner would be him. It is a pity that as a top scientist in the field of microbiology in the world,
Ka, his research on microorganisms is definitely unparalleled by others."
"When I was still doing research at Johns Hopkins, I heard that Dr. Mikasu invented a drug that can inhibit the expansion of tumor cells through research on single cells of a certain microorganism. That matter can be said to be unprecedented abroad.
There is a lot of excitement. If that drug is invented, it will definitely be a blessing to the oncology community."
"That experiment attracted the attention of countless people at that time. As a star experiment abroad at that time, scientific research funding reached 1.2 billion U.S. dollars. All the experimental data and experimental equipment, and the participants were the top people in various industries. The first phase
After the animal experiments were successful, major institutions and pharmaceutical companies made huge promises, and even prepared nearly 2 billion in reserves for subsequent clinical trials."
"At that time, "Nature", "Science" and even Time Magazine were ready to put Dr. Mikasu Tranly on the cover, waiting for the results of his clinical trials!"
"It's a pity... In the first phase of the clinical trial, all the experimenters who participated in it all died at an accelerated rate. Instead of curbing the growth of tumor cells, it actually inhibited the growth and development of normal cells in the human body..."
Speaking of this, Zhang Shulan sighed: "In the following years, they have been exploring the reasons, but unfortunately they have not found any reasons. Dr. Mikasu suffered from severe anxiety and depression under the pressure of public opinion and self-condemnation.
Committed suicide in the laboratory."
The room fell into silence for a while, and Bai Ye finally understood the whole story. It turned out that this incident was so famous.
Zhang Shulan said with regret: "I also attended Dr. Mikasu's lecture at that time. He was really the most amazing figure in the field of microbial engineering. His death is a great loss to the entire field of human bioengineering."
Speaking of this, Zhang Shulan suddenly looked at Bai Ye with a complicated expression: "If only you could have been born a few years earlier, maybe... he wouldn't have to die. He is only 59 years old and has achieved such great achievements..."
In the next few days, Bai Ye and Zhang Shulan reconstructed the experiment from beginning to end about the unstable gene, and still obtained this unstable base.
Zhang Shulan looked at Bai Ye and said, "Where do you want to send this article?"
Bai Ye shook his head: "I haven't thought about it yet, maybe MIO, because this is also an article in the field of experimental animals. But "Cell" is also fine. After all, Ke Ao is the editor-in-chief there, so let him publish this article.
Maybe it would be more appropriate, at least it would allow him to..."
Zhang Shulan was suddenly stunned and asked: "How about you send it to the Proceedings of the Chinese Academy of Sciences?"
Bai Ye: "Ah?"
Zhang Shulan suddenly blushed: "You are also a graduate student who is an academician of our Chinese Academy of Sciences. Why did you publish it in our journal..."
""Proceedings of the Chinese Academy of Sciences" is also at the SCI level, but the impact factor is relatively low. In fact, our level is good, mainly because the international influence is a little worse. If your article is published on it, maybe it can improve its international influence.
status……"
Bai Ye was stunned and asked awkwardly: "Is this okay?"
Zhang Shulan also smiled coquettishly: "Actually, it's the same wherever you publish it. The key point is to spread the news. This is the most important thing, isn't it?"
"Besides... your impact factor is now 258, which is better than many mentors, and you don't lack this article, right?"
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Bai Ye called Keao that day.
"Hello? Bai Ye, can you consider the time difference next time you call? It's 3 o'clock in the morning." Keao said helplessly.
Bai Ye was still thinking about this issue at this time: "Keao, if I tell you now that I found out the reason for your teacher's failure, will you think that I disturb your sleep?"
Suddenly, there was silence on the other side of the phone for a moment: "This joke is not funny..."
Bai Ye smiled: "What I said is true. I have really calculated it. The failure of the entire experiment has nothing to do with your teacher."
Keao was stunned: "Is what you said true?"
Bai Ye nodded: "Perhaps you can come to the Chinese Academy of Sciences in Kyoto. I have a detailed experimental process here."
The next afternoon, Ke Ao arrived. As soon as they met, Ke Ao walked towards Bai Ye with red eyes: "Are you sure what you said on the phone is true?"
Bai Ye nodded: "Come with me, I will take you to prove it yourself."
Bai Ye took Ke Ao and Zhang Shulan, and the three of them restored the experiment again. After seeing the results of the experiment, Ke Ao burst into tears.
A tall man about 1.8 meters was crying like a child, and Zhang Shulan was also a little bit unbearable.
Three days later, "Proceedings of the Chinese Academy of Sciences" published a special issue. The cover was not Bai Ye, but the KM mouse, and the image of Dr. Mikasu Tranly.
There is a title on the cover:
"Avenging those past experiments, the real culprit of deaths in clinical trials is actually unstable guanine"
The influence of "Proceedings of the Chinese Academy of Sciences" is still there, especially in Asia. After all, the technical content is still very high.
Therefore, the special issue has just been published and has aroused heated discussions among many people.
"Isn't it possible? We have been using the km mouse for so many years, but there is something wrong with it?"
"Generally there will be no problem. Didn't you see what it said above? Only under special conditions will there be a trace of variation."
"But... this is also terrifying!"
"It turns out that Dr. Mikasu died because of rats!"
"Oh! Oh my God, is this true? It's unbelievable."
For a time, many people in the entire scientific research field who paid attention to bioengineering information saw the information in this weekly article and immediately started discussing it.
This news was so shocking that everyone had to doubt his reliability.
The km mouse that people have used for so many years turns out to be an unstable mouse, and may even change differently from the human body. This is terrible.
Moreover, not only these bystanders, many examples of scientific research failures began to reflect on whether they used km mice in the first place and how much impact the mice had on their experiments.