Lidocaine spray and lidocaine gel are topical drugs and are very low-concentration anesthetics used on the skin, so they are relatively easier to obtain approval.
Generally speaking, the difficulty of drug approval is as follows: intravenous drip drugs are the most difficult, oral drugs are second, and topical drugs are relatively easy.
But even so, patients' trust in drugs that are not officially on the market is still relatively low.
Therefore, when the doctors negotiated with the patients, there were still very few people who accepted the trial. On the first day, there were 60 hospital beds and less than 10 patients received dressing changes. After all, no one lacked the subsidy.
However, there is a kind of pain called pain that is too embarrassing to mention, such as the pain in the anorectal department.
The lidocaine concentration of this kind of spray is very low, and it will only spread locally and infiltrate in the surrounding area. The drug concentration is very low. Again, the price is that it lasts a long time, which only lasts for a few minutes.
However, this is enough time for dressing changes in the anorectal department, and other patients are also in a wait-and-see state about using this spray.
When the first batch of patients participating in the experiment were ready to be discharged from the hospital, they deliberately reviewed various indicators, including routine blood tests, liver and kidney function and other safety indicators, and found that short-term use of this spray would not cause too many drug reactions.
Moreover, Check and Balance Medicine has not been idle during this period. It has conducted various experiments and tests on the medicinal ingredients of "Penlixiao", and studied a series of reactions such as the lethal dose and disabling dose of the drug.
The conclusion reached is that a one-time external use of 100ml has a 10% chance of causing some adverse reactions.
A bottle of "Penlixiao" is only 35ml, and a dressing change may only have 1-2ml, and it is in the form of a spray, so it will not cause a strong reaction.
This certificate with an official signature was sent to the Anorectal Department of Puze Hospital. With this safety certificate, more and more people are willing to use it.
What is the most important thing?
Every dressing change in the anorectal department is like going to the execution ground because it hurts!
However, the ten dressing changers who tried to use "Penlixiao" were very quiet. After the dressing change was completed, the patients did not feel the discomfort caused by the dressing change. This personal experience and feeling immediately made the people around them shaken.
.
And the safety certificate Bai Ye brought made them accept it.
After several days of testing, more and more patients began to actively apply to use this dressing-changing tool!
Not only that, the use of foam dressings has received unanimous praise from patients.
After all, lidocaine spray is a drug after all, but disposable foam dressing is different. It is something like tape. This kind of dressing is easier for people to accept.
So this was carried out relatively smoothly, and the case collection was also very smooth.
Not only Puze Hospital, Check and Balance Group began to try out outstanding hospitals to promote and use it, provide it free of charge, and collect samples for data feedback.
On October 19th, Bai Ye sat in his dormitory and started analyzing a lot of data, conducting a comprehensive evaluation of these two drugs through various data.
The World Pain Scale is the most intuitive scale to test the effectiveness of "Penlitix", while the safety analysis uses conventional analysis.
The observation indicators of dressings use the international relevant recovery standard scale in the anorectal field, and everything is done in accordance with the world's mainstream standards.
In two days, Bai Ye had already prepared all kinds of information in his hand, and Pan Xiangnian notified him to prepare to leave for Tokyo in these two days, asking him to prepare what he needed to bring.
……………………
On October 21st, Pan Xiangnian and Bai Ye prepared to set off with their luggage. There were dedicated people in charge to guide them. They were always staff sent by the sponsor to take charge of the experts and professors who were invited to attend the meeting.
Bai Ye packed his things in advance and followed Pan Xiangnian to a temporary gathering place.
There are many people here. After Pan Xiangnian entered, everyone greeted him one after another. The medical circle is not big, especially those in the same industry. They often come and visit, and they meet several times a year, so they are very familiar with each other.
"Director Pan, here we come!"
"Hello, Director Pan, I'm just waiting for you."
"Yes, long time no see, Director Pan."
Pan Xiangnian looked at everyone and said hello one by one. Pan Xiangnian is already in his fifties this year and is relatively well-known in the anorectal field in Kyoto. He belongs to the older generation of directors, so everyone respects him more.
At this time, a man in a suit and glasses of a similar grade came over. Pan Xiangnian looked at him, smiled, took the initiative to greet him, shook hands, and said with a smile: "Director Li, are you back? Haha, I haven't seen you for a long time."
The other party also patted Pan Xiangnian on the back: "Well, I haven't seen you for a while. I just came back. If I don't come back, I will receive a meeting notice and I have to go out. Haha, but I won't do it this time with you, Lao Pan."
boring."
Pan Xiangnian smiled: "How can our anorectal department's annual meeting be without Director Li? Your Union Medical College is the birthplace of our domestic anorectal department's guidelines. After studying for so long this time, you have to give it to everyone at the annual meeting in Tokyo.
Guy, you have such a long face!"
Li Muyang chuckled, looked at Bai Ye, and said, "Huh? Lao Pan, you actually accepted a graduate student?"
Pan Xiangnian has been promoted to senior high school for more than ten years. Associate senior students and above can actually teach graduate students. However, Pan Xiangnian has never recruited a single student in all these years, so he was a little surprised to see Pan Xiangnian taking Bai Ye with him.
"No, this is a regular trainee in our department, a student of Director Liu of our hospital." Pan Xiangnian shook his head, and then introduced to Bai Ye: "Xiao Ye, this is Director Li Muyang, director of the Anorectal Department of Union Hospital.
A leader in anorectal medicine in China.”
Bai Ye smiled and said hello: "Hello, Teacher Li, my name is Bai Ye, and I study encephalopathy."
Li Muyang nodded thoughtfully and said, "Young man is quite energetic."
There were not too many people going to Tokyo this time, but not too few. There were nearly twenty people in the entire Kyoto city. After the group gathered, a dedicated person in charge led them onto the plane.
As soon as he got on the plane, Bai Ye heard the sound from the system:
[Ding! Unlimited mission: This trip is worth it. The mission is triggered. The trip to Tokyo is hard-won. The system will evaluate you based on your performance. Tip: This is an unlimited mission. Try to improve your performance and influence. You
The greater your influence, the more amazing your performance, the richer your harvest will be. Please let go of your courage. How bold you are, how productive the system will be!]
Bai Ye was stunned for a moment. Unlimited missions were amazing. Bai Ye had a deep understanding of the power of the items produced by the system. Thinking of this, Bai Ye was full of expectations.
It's just... this tip is a bit touching: work hard to improve your performance and influence. The greater your influence, the more amazing your performance, the greater your rewards.