Chapter three hundred and forty-eight: a cross-era nail
[Ding! Obtain absorbable bone nails. Product characteristics: The initial bending strength of the material is 375mpa, the shearing strength is 320mpa, the strength maintenance time is 1218 weeks, and it can be completely absorbed by the body within 3 years. Compared with traditional materials, the degradation speed and bone
It matches the healing speed and has excellent conductivity, which is conducive to bone healing.】
[Ding! Congratulations, you have received an absorbable bone nail. Tip: This is an absorbable bone nail produced by Buis Company. This bone nail is the fourth generation bone nail, and its composition material is a new synthetic biodegradable material.
Materials, many clinical advantages.】
[Reminder, this material is a polymer material, with poly-kl-lactic acid as the main raw material, which can be decomposed into carbon dioxide and water in the human body and is harmless to the human body. Compared with traditional bone nails, it combines the strength of traditional titanium metal
Advantages and absorbable advantages of polymeric lactic acid products... The advantages are obvious. Researching this item requires: Materials Science lv6, Orthopedics Skills lv6, Biomedicine lv5.】
The moment Bai Ye saw the nail, he naturally understood what it was!
After all, my system is different from others. It is a good system that serves the host with conscience, huh!
Naturally, what comes out cannot be waste.
At present, the main material of absorbable bone nails is pla material. As an orthopedic internal fixation material, pla material has even revolutionized traditional materials. It can be said to be the most advanced orthopedic internal fixation material in the world.
As we all know, traditional fracture internal fixation materials are generally made of stainless steel, titanium and their alloys. However, long-term implantation can cause corrosion, allergies, osteoporosis due to stress shielding, and postoperative recurrence of fractures. Most of them require two
Take it out once.
In recent years, many fracture fixators made of absorbable materials have been used clinically, and have achieved good internal fixation effects.
Compared with metal internal fixation, its most clinically attractive advantage is that patients who receive polymer biodegradable material devices for fracture internal fixation do not need to perform a removal operation after the fracture heals.
Absorbable boards and nails are generally made of absorbable biodegradable material polylactic acid. Polylactic acid is non-toxic to the human body and has good biocompatibility. It does not cause inflammatory reactions and foreign body rejection reactions in surrounding tissues. Its degradation products are
Glycolic acid and lactic acid can participate in the carbohydrate metabolism cycle in the body. After a series of biochemical reactions, they are finally degraded into carbon dioxide and water and are excreted from the body.
No residue, no irritation to tissues, and no toxic or side effects. In addition, polylactic acid has good mechanical strength and elastic modulus. By adjusting the molecular weight and selecting different polymerization methods and molding methods, the mechanical properties of polylactic acid can be adjusted and controlled.
and degradation speed to meet different clinical needs.
Moreover, what surprised Bai Ye the most was the several properties of this new material, such as the material's initial bending strength, shear resistance, etc.
Because the main function of bone nails and fixation plates is to serve as the fracture ends of bone nails, these fixation materials need to be able to withstand strong force and tensile strength.
Although this kind of pla material is absorbable, its strength is very insufficient, which is a very important drawback.
In the past, it was precisely because of the weak mechanical properties of this absorbable biodegradable internal fixation that it limited its widespread application.
In practical clinical applications, polymer biodegradable materials must have physical properties such as considerable hardness, sufficient stability, and ultimate complete degradation in the human body without causing any complications.
Over the years, through continuous innovation and research by foreign researchers, polymer biodegradable implantable devices have met the above requirements and achieved the intended goals.
However, even so, the initial bending strength of the material is only 175mpa, and the shearing strength is 120mpa, but the strength of the nail in my hand has more than doubled!
This more than twice the capability is comparable to most alloy materials today.
As for the degradation speed, in fact, the faster is not the better. The degradation speed of 12-18 weeks and the resorption period of three years are perfectly in line with human fracture recovery.
When the fractured bone segment is completely healed, it begins to be disintegrated and absorbed in the body.
This degradation rate not only ensures good in-situ healing of the bone segments, but also avoids the stress shielding effect in the later stages of bone healing, which is beneficial to the reconstruction of the later stages of bone healing.
It can not only promote bone healing and reconstruction, but also be decomposed and excreted from the body after healing, avoiding possible adverse reactions that may occur if the implant remains in the body for a long time.
At present, the raw material used in absorbable bone fixation products is mainly PLA (polylactic acid). PLA has been widely used in clinical treatment because it has obtained certification from the US FDA.
Although it is a bit embarrassing, I have to admit that all the materials such as bone pins, bone nails, orthopedic fixation plates, etc. currently used in our country are imported!
Yes, all of them!
Because there is a large development lag in our domestic Pla synthesis technology, the synthesis technology has not yet achieved a breakthrough, especially the lack of high-purity chiral monomer preparation technology, which has resulted in the industrialization of Pla orthopedic products.
Of course, this does not mean that pla materials are perfect. It can only be said that there are a lot of improvements compared to previous materials.
At present, the shortcomings of pla materials as orthopedic internal fixation materials include the following aspects:
1: It does not have bone conductivity, and the speed of repairing bone defects is very slow. For large bone defects, it is difficult to achieve complete bone repair.
2: The mechanical strength of the material is not enough to be used as an internal fixation material for fractures in load-bearing parts:.
3: Its early biodegradation rate is too fast to ensure that it can meet the mechanical property requirements before new bone tissue grows out, and its mid-term degradation rate is too slow, so that there are still residues left after new bone tissue grows out.
Cause complications in the body.
Therefore, the nail that Bai Ye obtained is completely an evolved version of modern orthopedic internal fixation materials!
Moreover, although pla material is leading, there is still a potential risk factor. Bai Ye remembered that when reading the paper at that time, many leading experts in Japan found that pla material was actually carcinogenic, and its experimental incidence rate was as high as 44%.
However, some scholars have questioned its experimental design, so this issue requires long-term observation.
However, this also just shows his shortcomings!
Therefore, when Bai Ye saw this nail, his heart jumped for no reason.
This is more than just a nail, more than just a product, this is a new era!
Bai Ye feels that if this kind of absorbable bone nail can be developed and the materials can be researched, it can be used as an orthopedic internal fixation material.
Moreover, if this material is used properly, it can be used in many aspects and fields.
Once this is done, it will be a future, an unlimited future!
Thinking of this, Bai Ye was a little excited.
After all, we ourselves can research and produce world-leading orthopedic materials.
Bai Ye is confident that what he can do is open up a new era.
Bai Ye put away the bone nails carefully, thinking about it.
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To be honest, Bai Ye found a problem, that is, as the level of subject skills improved, he found that the surrounding supporting facilities were increasingly unable to keep up.
He even feels that if he wants to further improve his subject skills, medical materials, medical equipment, medical drugs, etc. are very important and critical things.
If you think about it, it’s a very intuitive question.
For example, what is the difference between an orthopedic surgeon 30 years ago and an orthopedic surgeon of the same level today?
There are many differences, because with the development of science and technology, concepts and so on are constantly updated.
In the past, there were few CT and MRI machines in China, but now with the help of these auxiliary tools, many previously difficult and complicated diseases have been discovered and treated.
This is progress!
Therefore, medicine, whether it is traditional Chinese medicine or Western medicine, is actually a discipline that treats diseases and saves lives.
Their ultimate goal will be to serve mankind.
Thinking of this, Bai Ye smiled gratefully at the virtual screen.
Without him, maybe I would just be an ordinary person!
When Bai Ye returns to China, the first thing he needs to do is to improve the talent allocation of scientific research institutes.
No!
You have to start researching now. Maybe you can hold a job fair in Los Angeles tomorrow!
Thinking of this, Bai Ye felt that this matter was very feasible.
After all, I just cured your hero in Los Angeles. In Lao Bai's words, I am now a popular figure and one who is at the forefront of public opinion.
Moreover, Los Angeles is also a great place!
California Institute of Technology, home to the California Institute of Technology, is a world-famous private research university. Although it is small, it has a long-standing reputation in the world's science and technology community.
Its dominant disciplines are in physics and chemistry, astronomy and space science, and it is also an international leader in materials science.
Although this school is very small, with only over 2,000 students in total, this school has produced 36 Nobel Prize winners in history!
What a terrifying number!
Moreover, it is an institution with the highest density of Nobel Prize winners in the world.
Therefore, Bai Ye would not forgive himself if he returned empty-handed.
Thinking of this, Bai Ye felt that it was necessary to talk to Mr. Wynn about this matter tomorrow.
Maybe tomorrow I can take a top-notch talent back to college and take it back. I am very hungry for talents right now.
Orthopedic Research Institute Bai Ye does not plan to operate it as an ordinary hospital, he wants to develop this institute as an authoritative base for orthopedics in the world.
This is not just about research and treatment, but also about any products in the field of orthopedics. I have the final say!
This is authority!
In terms of academics, medical standards, medical drugs, medical equipment, medical talents and other fields, they are all at the highest level in the world!
As a distinguished member of life, Bai Ye feels that he should be more courageous.
ps: A veteran feels that he can grow a little longer... I have decided to write more big chapters in the future, which will make reading more comfortable. What do you think?