The time soon came to the 30th day of the twelfth lunar month, the day for family reunion, but on this day, the lights in the institute were still brightly lit, and everyone seemed to have forgotten what New Year's Eve meant.
Time is never wasted. On this day, just as the New Year's bell rang, a big news came from Cheng Ran's research room.
A special protein that is sensitive to cobalt and chromium elements was discovered. This compound is a substance extracted from km mice.
The discovery process is also very simple, which is to create models for experimental animals such as km mice, guinea pigs, rabbits, and domestic pigs. It is required to inject a certain amount of cobalt-chromium free substances into the body, but these cobalt-chromium free substances need to be specially processed.
Radioactive labeling is used to observe the main route of entry of these substances into the animal's body.
This is a method that Bai Ye came up with. Although he has found these substances through [deep scanning], it does not mean that he can tell others clearly.
Therefore, the first step is to put forward various hypotheses. Through observation and analysis, Bai Ye found that the main attachment sites of cobalt-chromium elements are still nerve cells, blood vessel walls, liver and kidneys.
While analyzing each screenshot, Bai Ye suddenly discovered a strange phenomenon, which is how cobalt chromium ions enter the white matter of the brain!
By comparing tens of thousands of screenshots of different sizes, Bai Ye discovered an interesting thing. On the cell membrane of vascular endothelial cells, a protein channel has a cobalt ion embedded in it. It is in a pure free form.
, and does not react with other substances.
This aroused Bai Ye's curiosity.
Continuing to observe other photos and information, he found a magical secret this time, which is how cobalt enters the neurons of the white matter of the brain through the blood-brain barrier!
You must know that the blood-brain barrier is one of the body’s strongest defense systems!
It is the barrier between the plasma and brain cells formed by the brain capillary wall and glial cells, and it is also the barrier between the plasma and cerebrospinal fluid formed by the choroid plexus.
These barriers happen to prevent certain substances from entering the brain tissue from the blood, and most of these substances are harmful substances, as if the human body has a recognition function for harmful substances and can keep them out.
It is difficult and easy for various solutes in the blood to enter the brain tissue from the brain capillaries; some pass quickly, some pass slowly, and some cannot pass at all. This selective permeability phenomenon makes people imagine that there may be restrictions on solute permeability.
This structure can make the brain tissue less or even immune to damage by harmful substances in the circulating blood, thereby maintaining the basic stability of the internal environment of the brain tissue and playing an important biological role in maintaining the normal physiological state of the central nervous system.
significance.
Therefore, when Bai Ye was observing how cobalt ions passed through this barrier, he suddenly discovered a mysterious protein!
The cell membrane has pathways, including some protein channels, and it is obvious that this cobalt element penetrates the blood-brain barrier through this protein, causing damage to neurons and some damage to myelin.
This discovery is crucial!
So he proposed an animal model to look for this protein. Since cobalt can pass through the blood-brain barrier of the human body, it must also exist in other animals.
To this end, Bai Ye asked the experimental team to increase the dosage of cobalt, even to the extreme dosage and maximum lethal dosage.
As long as the animal can survive, continue to increase cobalt ions, hoping to see whether this probability can be increased by observing a high-concentration environment.
These people are professional scientific researchers, they know a lot and they do it very quickly.
A gentle man with eyes under Cheng Ran's experimental group and a tall classmate of his discovered a protein together during the experiment. He has a certain affinity with cobalt ions. This protein is very rare and is found in
A special protein found in km mice.
This made the two of them excited instantly!
This was definitely big news. After getting the news, the two people quickly reported it.
It is almost twelve o'clock. Everywhere in China is welcoming the New Year with joy, but many rooms in the Baiye Research Institute are still brightly lit.
Of course, most people are at home, and not many people are in the laboratory.
Since Bai Ye's family members were all in the United States, he naturally did not return to the Puze Family House to celebrate the New Year. Li Ziyan invited Bai Ye to go home for the New Year, but Bai Ye refused.
Because now is the critical time of the experiment, Bai Ye doesn't want to relax at this time. After all, there are still a lot of people abroad waiting to see the joke!
Gao Yueyang received an invitation to go to the Spring Festival Gala this year, and Liu Boli wanted to accompany his family. After all, he already needs to take care of himself at such an old age, and Cheng Ran even went to the Spring Festival Gala this year to receive commendations. As a leader in science and technology, the country
Every year some people are commended.
Bai Ye was lucky enough to go there, but because he went to Mai Country, his mother took it on his behalf.
Anyway, most of the experts, professors and academicians are going home to celebrate the New Year at this time. It is these young people who stay in the institute. They are hardworking and enterprising, and they also have a longing for the future.
Just like the glasses man Chen Yu and his classmate Qin Yue, a tall man, they basically spend all their time in experiments every day except for their rest time.
Doing experiments is not done all the time, most of them are doing experiments and waiting for the results to create new results.
During the time they were waiting for the results, they used it to check the information, which was very fulfilling.
When they reported the news to Bai Ye, Bai Ye ran directly to their laboratory.
Seeing Bai Ye coming, the two of them spoke excitedly and felt awkward!
"Dean, we found a substance that is a special transporter on the cell membrane. His km mouse... We found that it has a certain affinity and specificity with cobalt ions. This specificity allows proteins and ions to form
A special state that allows cobalt ions to penetrate the cell membrane and enter the organs."
Bai Ye's eyes lit up and he quickly looked at the microscope. Sure enough, under the high-power field of view, he found a cell membrane with a special shape, and the cobalt ions were specially labeled, so it could be found under an electron microscope!
Bai Ye suddenly became energetic: "Where did you find it?"
Qin Yue said excitedly: "It was found on the capillaries of the kidneys."
Bai Ye understood that they found this substance on the blood vessel walls of the kidneys, and its shape was exactly the same as the one he had found on his human body during the [deep scan].
good news!
Definitely good news!
His discovery was actually confirmed by these two young men. The more Bai Ye thought about it, the happier he felt.