His reputation is unknown to people in the entertainment industry like Su Xingmou or Gao Benben, and policemen like Zhuang Wei who are so busy have no time to pay attention to it, but as long as they have a slight brush with the scientific community, they don't even have to brush it off.
If you are a little interested, you should have heard of it.
He studies proteins, to be precise, it is called proteomics, the most cutting-edge field of life science.
Since the human genome project was roughly completed, people have discovered that not all base sequences have been determined clearly, and the genetic secrets of life will be revealed. Genetic information does not directly participate in life activities, but indirectly operates organisms by controlling the formation of proteins.
So when the human genome framework map was released, "Nature" published the news of the establishment of the Human Proteome Research Organization at the same time, telling people that from now on, the forefront of biology will be proteomics.
It's so important!
Frederic Sanger, the only person to win the Nobel Prize in Chemistry twice, won his first prize for protein sequencing.
This situation reached its peak last year, in 2018!
In this year's Nobel Prize, the three natural prizes are surprisingly won by biology!
And proteomics occupies two seats among them!
The Physiology and Medicine Award is given to research on the mechanism of molecular brakes that inhibit immune cell defense or kill cancer cells and pathogenic microorganisms, and is related to proteins.
The chemistry prize is about enzymes, which are proteins with high catalytic efficiency.
As for the optical tweezers technology that won the Physics Prize, it is also an important technical tool for studying the living state of biomolecules.
Some people may say, does the excitement have anything to do with Ye Han's research?
There really is...
His research focus is on basic structure determination of proteomics.
Protein sequence determination means figuring out the order of amino acid residues, which is equivalent to figuring out molecular expression;
There is also structure determination, which is to figure out the three-dimensional structure of the protein, because the way long chains are bent in space will greatly affect the function and expression of the protein.
Sequence determination is not too difficult, but it is useless; structure determination is more useful, but it is also more difficult...
How difficult is it?
The order of arrangement is often called the primary structure.
On top of this, there is the secondary structure of the local spatial arrangement of atoms in the main chain of the polypeptide chain; the super secondary structure of adjacent secondary structures in the polypeptide chain that are spatially folded close to each other; on this basis, the tertiary structure formed by further twisting and overlapping
Structure; and the quaternary structure formed by the combination of secondary bonds between polypeptide chains...
Therefore, if sequence determination is at the level of a primary school student, then structure determination is at least a university undergraduate level.
If sequence determination is a linear equation of one variable, then structure determination is at least a fifth degree equation of one variable... Such difficulty.
The current common practice is to predict spatial structure through sequences, and there are homology modeling methods; threading methods, or stringing methods, and folding recognition methods; and de novo prediction methods, which use supercomputers or distributed computing to brute force crack.
The three methods have the same level of difficulty.
The ones that are as easy as before are more limited; the ones that are unrestricted are more difficult.
Among them, the ab initio prediction method is the most difficult, but it is also the most applicable.
Because it is based on molecular dynamics, it does not require homologous proteins or core folding databases. In addition to being extremely computationally intensive, it is almost perfect.
Ye Han's paper optimized this method through a purely mathematical algorithm, which greatly reduced the calculation amount of certain steps while ensuring accuracy.
Although biologists don't need much IQ, and more would be a waste. It is a profession that requires more physical strength, but it is different when you reach Ye Han's level.
His thesis is hailed as, after the Duke de Broglie, another doctoral thesis that can directly win the Nobel Prize! Or, it can also win the Fields or Turing Medal...
There must be some unscrupulous flattery from the domestic media, but it is indeed very impressive!
For this reason, he and Cao Yuan, who discovered the magic angle superconductivity of graphene, were called "Young Geniuses", "Twin Stars of the University of Science and Technology", and "Double Students Studying Abroad"... and a senior from their same school.
Together, he appeared on Nature's list of the top ten most influential scientific figures in the world in 2018.
There are also two scenes, and the exposure rate is extremely high.
Even until now, many headlines and public accounts have shamelessly used his schooling experience and overseas study experience to demonstrate the gap between domestic and foreign education and the success or failure of cramming education and quality education. Of course, the main purpose is to attract attention and attract traffic.
After learning about Ye Han's achievements, Hu Stan was overjoyed and bowed his head.
To be precise, I am kneeling down to worship and popularizing science at the same time.
"Boss! Ye Shen! How come you, you, you, you, you, you, you, you, you, you, you, you, you, you, you, you, you, you, you, how did you come here?" I even forgot that there are no master's and doctoral students here, "I am willing to study as your doctoral student, and I am committed to you!"
Although this person is two years younger than me, but... there is no priority in learning, the master comes first!
This is the legendary Ye Shen who already holds the Nobel Prize in his hands. He is a sure future scholar. If we don’t hug him tightly now, when will we wait?
Ye Han moved away calmly.
Students who stab their teacher in the lungs one after another, do not want to bully their teacher and destroy their ancestors like this!
==========
Although Hustan did popular science...
Su Xingmou still timidly asked the question in her heart: "Imo, what is ipho?"
What is imo? What is ipho? Su Baibai, you are so white!
Hu Stan's nose was about to smoke: "It's just a Mathematical Olympiad. Have you never heard of this?"
Once you say this, everyone will understand.
imo, the full name is the International Mathematics Olympiad; ipho, the full name is the International Physics Olympiad.
I think Hustan also participated in it back then.
Of course, it wasn't an international competition or a domestic competition, it was a school trial... If he didn't pass, that was when he was 16 years old.
From this we can also see that Ye Han's strength has been consistent from childhood to adulthood.
Winning an IMO silver medal at the age of 11 is on par with Australian Chinese mathematician and Fields Medal winner Terence Tao.
It's a pity that he switched to ipho in the second year and did not participate in IMO. Otherwise, he would probably be like Tao, winning a bronze medal at the age of 10, a silver medal at the age of 11, and a gold medal at the age of 12, leaving a good story.
Everyone present finally knew who Ye Han was.
I would also like to thank various public accounts for generating traffic and reading endless reports that everyone has read more or less. It’s just that for such academic reports, people generally don’t pay much attention to their appearance...
In fact, there is no need to learn too much about science. Even if you explain academic matters, no one will understand them.
Hustan, who has one of the highest IQs and is usually very arrogant and arrogant, knelt down and hugged his thighs, which is enough to explain everything.
Duan Yan can't do it even if he wants to bow his head and lick it like this...
The crowd was in awe for a moment.
This guy, how old is this guy? Is he a Nobel Prize-level scientist? You know, someone as awesome as Sheldon only won the Nobel Prize after the finale...
Ye Han had no choice but to maintain a social smile: Ordinary people only know Sheldon.