Will this case be operated on here? Xia Shu was very interested and asked again.
Yang Ping nodded: "Of course, we need to prepare in advance and come up with the best plan in advance. Let's find a time to discuss it formally. Let's check the information in the past few days to get a comprehensive understanding of this case."
Yang Ping does not plan to discuss it now, because many people have not checked the information and lack this knowledge, so the discussion will appear feeble and of little value.
So Yang Ping asked Song Zimo to distribute the case information, let everyone take time to look at it carefully, and then choose a time for everyone to gather in the conference room to discuss it seriously. After dealing with these matters, Yang Ping decided to go to the laboratory to see Lu Xiaolu.
With so many things happening recently, Yang Ping was worried that Lu Xiaolu's mood might be unstable, so he asked Tang Shun to take more care of him, and he also tried his best to take time to visit so that he could feel the warmth of the team.
Guan Ruyan has never appeared again, and his social accounts have all been cleared and there is no longer any sign of activity. Some people say that he went to the United States because an alumnus who graduated from Nandu Medical University saw him in the United States. It is said that he was seen delivering food. Once
His takeaway was robbed on the street, and he sat on the ground crying. Seeing that he was Chinese, the schoolmate went up to ask if he needed help. What surprised the classmate was that this person was Professor Guan whom he had met before, but this gentleman
He refused to admit that he was Guan Ruyan, kept saying that he had recognized the wrong person, and then stumbled away.
No matter what, Guan Ruyan got the punishment he deserved.
President Rao resigned voluntarily to take responsibility for the incident. Professor Su Qingyun was appointed as the president of Nandu Medical University and concurrently as the director of the First Affiliated Hospital of Nandu Medical University. This incident had a profound impact not only on Nandu Medical University but also on the entire education sector. It caused a stir in universities across the country.
In the academic rectification movement, some things have a long way to go and cannot be accomplished overnight.
Yang Ping chatted with Lu Xiaolu for a while and asked about the current situation of the experiment. Lu Xiaolu's mood was very stable. He now devoted almost all his energy to scientific research.
Ding Xinyu resigned from Nandu Medical University and went to work as a teacher in a vocational high school. This was her own choice. Lu Xiaolu respects her choice. Lu Xiaolu often takes the time to visit her and her children, sometimes
Help children with their homework.
For the study of tumor cell apoptosis, Yang Ping began to think about a new route. He wanted to find a suitable virus, chimerize the virus with K factor, and then inject them into the human blood, allowing the blood to carry this special
The virus travels throughout the body looking for tumor cells and then kills them.
Using viruses as tools, judging from the literature, this method has been tried by some people. Oncolytic viruses use this principle. Oncolytic viruses are a special type of virus that have the ability to replicate and have a certain ability to kill tumors.
The discovery of oncolytic viruses was an accident. At that time, a cervical cancer patient was injected with a rabies vaccine because she was bitten by a dog. The vaccine itself was a modified virus. After the virus entered her body, it accidentally killed the patient with cervical cancer.
Tumor cells miraculously cured this patient's cervical cancer.
But this was an accidental event, and no one was able to solve the mystery. Naturally, nothing valuable for the treatment of cervical cancer was discovered. However, the chapter on using viruses to treat tumors has since been solved.
In 1991, Martuza et al. published an article in Science magazine, which stated that genetically modified HSV has a certain effect in the treatment of malignant glioma. Since then, oncolytic virus therapy using HSV has attracted increasing attention from the medical community.
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The principle is to genetically modify some viruses with weak pathogenicity that exist in nature to make them into special oncolytic viruses, and use the inactivation or defects of tumor suppressor genes in target cells to selectively create oncolytic viruses.
Infect tumor cells without harming normal cells. Oncolytic viruses replicate in large quantities in tumor cells and eventually destroy tumor cells. At the same time, oncolytic viruses can also stimulate immune responses and attract more immune cells to help continue to kill remaining cancer cells.
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In recent years, there have been more and more studies on oncolytic viruses. The most intensively studied oncolytic viruses include adenovirus and herpes simplex virus type I, which have entered the clinical trial stage.
However, there is currently no study in the world that combines oncolytic viruses with protein factors that initiate tumor cell apoptosis. Yang Ping plans to start his own experiments in this area. Yang Ping's idea is now very clear, transforming viruses into tools
, combine K factor with them, and then let the virus carrying K factor infect the target tumor cells, continue to replicate and infect, and eventually kill all the tumor cells.
But what kind of virus is suitable for your transformation? This virus must have existed for a long time, so that the human body can adapt and not cause unexpected reactions. Secondly, this virus must have weak curing ability or no lethal ability.
Good, it will not cause harm to the human body.
M13 bacteriophage!
Yang Ping screened various viruses in his mind, and finally felt that the most suitable tool for K factor was M13 phage. This virus often lives in bacteria or inside the human body and is not harmful to the human body.
M13 phage has a very slender appearance. It is a single-stranded DNA encapsulated in a cylindrical protein shell, with several other types of proteins at both ends. The entire M13 phage is like a precision machine composed of miniature proteins and DNA.
The proteins on the sides and ends of the cylindrical phage can adsorb different material molecules, and different phages adsorb different molecules. In this way, the phage that is most suitable for binding to a certain molecule can be found through experiments. For example, a certain phage can be found through experiments.
A phage capable of adsorbing K factor.
How to find such a specific phage?
The simplest method is to put the phage into a beaker containing K factor, then increase the acidity of the solution to wash away the phage that cannot bind to K factor. Repeat this many times, and the remaining phage will be able to adsorb K factor.
This chapter is not over, please click on the next page to continue reading! Of course, this method is the clumsiest, primitive and simplest. If you use cutting-edge genetic engineering technology to change the proteins at both ends of the phage, you can create something that can
Phages that adhere to different molecules, and the proteins on the side of the phage also have adsorption capabilities, so that many phages can be produced using different combinations, and the K factor can be adhered to both ends or sides, so the success rate of the experiment is significantly increased.
a lot of.
Yang Ping wrote his thoughts on A4 paper and handed it to Lu Xiaolu. Lu Xiaolu was very surprised after reading it. The breadth and depth of Professor Yang’s knowledge was staggering. Otherwise, how could he break down the barriers between various fields?
Come up with such a wild and unconstrained idea.
"Start again according to this idea!" Yang Ping ordered Lu Xiaolu.
Lu Xiaolu regretted the original research results: "This is equivalent to overturning all previous research and starting over. Isn't it a bit too radical?"
Yang Ping shook his head: "No, it might be a good thing to change the direction in time when you find that you are going the wrong way."
''Then let me try. In this case, your experiment is the field I am good at. When I was in Germany, I did research on phages and oncolytic viruses. I remember that there was a team at Heidelberg University working on oncology.
The mechanism of cell apoptosis, but I don’t know why they haven’t cooperated to study it after so many years?” Lu Xiaolu was very confused.
"Some thinking inertia is difficult to overcome. There are subjective reasons and objective reasons. The barriers between majors have deepened everyone's thinking inertia. For example, the pathogenesis of Castleman's disease has always been thought to be based on interleukin 6. Everyone focuses on it.
We have done a lot of research, and each research is from different angles. The terrible thing is that everyone seems to see a little hope in their research, so they go further and further down the wrong road. No one has ever thought that the mTOR signaling pathway may be more correct.
It's just like a car. When everyone's energy and financial resources are all focused on improving the engine, few people delve into the motor. Neither subjectively nor objectively can they change the direction.
Yang Ping told Lu Xiaolu.
"So I think it takes a lot of courage for you to change direction now." Lu Xiaolu said.
In fact, Lu Xiaolu didn't know that the reason why Yang Ping could overturn and start over at will was because he had a huge advantage that others didn't have: the cost of testing in the system space laboratory was extremely low. This allowed Yang Ping not to consider anything else but to follow his own wishes.
