The time it takes for a virus to replicate through division is 6-8 hours, which is an astonishing speed.
About one billion viruses are piled together and are about the size of a grain of rice. With one virus as the source of exponential division, it needs to be replicated 30 times to reach about 1 billion. 30 divisions take about 150 hours, which is 6
About days.
The virus divides so quickly, so the risk is high.
If all the split viruses do not mutate, or the changes after mutation are not significant and do not deviate from our expectations, there is generally no problem. Because the consequences of these viruses are already within the expectation and control of the experimenter, and the experiment
The viruses used by researchers have also been carefully selected and will not cause obvious harm to the human body. For example, measles virus and vesicular stomatitis virus have minimal negative effects on the human body and are transient.
The most terrifying thing is that the virus mutates beyond expectations and control during the iterative process. Once the virus mutates like this, its harm will exceed our expectations and control. These mutated viruses can still divide exponentially.
, the number is increasing.
If these brand-new viruses have some pathogenicity, once they enter the human body, there are no effective drugs to eliminate them, or the human immune system cannot eliminate them. This is tantamount to infecting the patient with a brand-new viral disease. Of course, it will happen.
The probability of this risk event is extremely rare.
The virus cultivation experiment must be conducted in a biosafety level three laboratory, so Lu Xiaolu needs to conduct the virus experiment in the high-level biosafety laboratory of Nandu Medical University. Currently, the stem cell laboratory and tumor laboratory of the Institute of Surgery do not have such facilities.
Conditions, these two laboratories are not prepared for virus experiments.
When Lu Xiaolu was studying in Germany, he had a lot of exposure to these multidisciplinary fields, so he was familiar with tumor immunological treatment, biological treatment, targeted therapy, and oncolytic virus therapy. This experiment was the most suitable for him.
The professors in the virus laboratory at Nandu Medical University were happy to cooperate with Sanbo Hospital, so they quickly reached an intention to cooperate, and a Nobel Prize-winning virologist introduced by Professor Brian would soon be working with Lu.
Xiaolu started cooperation and exchanges.
Yang Ping and Lu Xiaolu went to Nandu Medical University to inspect the virus laboratory. They had a long talk with Professor Zhang Zhiwei, the director of the virus laboratory. After the conversation, Yang Ping and Lu Xiaolu decided to walk around the campus of Nandu Medical University a few times. They rarely come here every time.
As long as he can spare time, Yang Ping will also walk in such a circle.
On a boulevard, from a distance, Yang Ping saw Principal Rao, who came to the school to apply for early retirement.
At that time, President Rao resigned due to the incident involving Guan Ruyan and President Ding. Professor Su Qingyun, the dean of the First Affiliated Hospital of Nandu Medical University, succeeded President Rao as the new president of Nandu Medical University and concurrently served as the director of the First Affiliated Hospital of Nandu Medical University.
In fact, President Rao is indeed a good principal, upright and upright, daring to act, and quite an upright scholar. During his tenure, he made great contributions to the development of Nandu Medical University and implemented many very meaningful reforms. Then
He also provided a lot of help to Yang Ping.
When President Rao resigned, Dean Xia, Professor Su, Yang Ping and others invited President Rao to dinner and held a farewell ceremony for him.
From a long distance, Yang Ping saw Professor Su and several vice-principals talking to Principal Rao, surrounded by a large number of students. In fact, these students were reluctant to leave Principal Rao. When they heard that Principal Rao was back to complete the formalities, everyone spontaneously
People gathered around and wanted to shake hands with Principal Rao.
Principal Rao also saw Yang Ping. The two stretched out their hands from a distance, then walked over and held each other's hands.
"Professor Yang, how are you doing lately? I heard that you have recently been conducting experiments on virus treatment of tumors. Professor Zhang Zhiwei from our school's virology laboratory is very good. He has worked in several top virology laboratories in the United States, Britain, and Germany.
Academic achievements are outstanding." Principal Rao is in good spirits and obviously does not have the retirement syndrome of leading cadres.
"Yes, we are here to talk to Professor Zhang about cooperation on this project. How are you doing now?" Yang Ping was also very concerned about Principal Rao's current situation.
"As for me, I have retired from old age and returned to my hometown. Not long ago, I went back to my hometown to worship my ancestors. The local government heard that I retired and hoped to ask me to go back and serve as a consultant to the government in education. For this matter, the county magistrate of our hometown came here three times.
, I couldn’t refuse, and agreed to go back and help with education, so as to use my spare energy and have something to do after retirement.” Principal Rao said with emotion.
It seems that Principal Rao is also a person who can't take any time off.
"Professor Yang, have you met Professor Zhang Zhiwei?" Professor Su usually calls Yang Ping Xiao Yang at home, and now outside, he is also called Professor Yang in a formal manner.
"I met you and talked for a long time. We just visited the laboratory. I told Professor Lu that it was a rare trip and we were going to walk around the campus." Yang Ping explained immediately.
More and more students gathered around, including many teachers. The entire road was crowded at both ends. The atmosphere was even more lively than when celebrities appeared. Yang Ping looked at it and saw that there were thousands of people, and the number was still increasing.
They have spontaneously stood on both sides of the road, leaving a gap in the middle.
"Principal Rao, we miss you so much!"
I don’t know who took the lead in shouting.
"Principal Rao, we miss you so much!" The shouts of the entire crowd sounded like waves, one after another, and finally turned into a uniform shout.
President Rao has been on leave since he took the blame and resigned. Today he officially came to go through the formalities for early retirement. Unexpectedly, less than two hours after his appearance on the campus of Nandu Medical University, so many people gathered.
Principal Rao was a little overwhelmed at first, and then his eyes turned red. He immediately took out a tissue and pressed it gently to his eyes, and then waved to everyone.
"I miss you too!" Principal Rao kept waving.
This chapter is not finished yet, please click on the next page to continue reading the exciting content! There is no room for people on the road here, and the woods on both sides are also full of people. They all gathered temporarily after receiving the news, and there is no organization or organization.
Banners, no flowers, only sincere shouts.
Principal Rao shook hands with the students and teachers who extended their hands, but he couldn't hold them at all.
A black car drove in, and Professor Su said: "The car is here."
"Professor Su, look, why bother you and arrange a taxi? I can just take a taxi myself." Principal Rao said while waving to the crowd.
Professor Su opened the car door: "No trouble, let the Nandu Medical University car take you there again."
"Goodbye, Principal Rao, you must come back often."
Principal Rao turned around and saw the waving crowd, and reluctantly got into the car.
---
The frequency of Sisi's transient dizziness is getting higher and higher, and the symptoms are becoming more and more obvious. Sometimes when the dizziness is severe, there will be a brief disturbance of consciousness. However, this kind of temporary disturbance of consciousness generally does not last very long, only a few seconds.
seconds.
Yang Ping knew that her dizziness was caused by an intracranial tumor. At this time, the intracranial tumor had affected the heartbeat center, causing a short-term suppression of the heartbeat. The suppression of the heartbeat would reduce or stop blood output, which would lead to a loss of blood supply to the brain.
Insufficiency, dizziness is a reaction to insufficient blood supply to the brain. If this heartbeat suppression continues to worsen, one day the brain will die due to prolonged insufficient blood supply.
Even if Yang Ping did not inform Sisi of her illness, the smart little girl knew that it was the last moment, because Yang Ping never told her about her illness or the next treatment plan. That is, there is no plan now, and she has no plan.
I have been mentally prepared to face all this calmly.
These days, every time Yang Ping makes rounds, he talks to her about the cactus and discusses his experience in growing desert succulents. Yang Ping never talks about his illness, and Sisi doesn't ask. Their chats around the cactus are very interesting.
joy.
The doctors, nurses and students who followed the ward rounds in the morning couldn't understand why Professor Yang didn't talk about the disease during the ward rounds, but only talked about cactus.
Every time she went for ward rounds, Sisi would read under the window. The lighting in the ward was very good. At that time, the early morning sunlight shone into the ward and shone on Sisi's body. She looked so peaceful, so calm and calm.
Yang Ping wanted to know what this little girl's inner world was like, and why she could be so calm in the face of death. Most adults couldn't do this.
In the afternoon, Yang Ping came to Sisi's ward alone for rounds. Sisi sat under the window again and read a book. The golden sunset had not yet receded and was shining on her body. Sisi looked like a beautiful flower.
Yang Ping walked over slowly and Sisi closed the book.
Yang Ping glanced at Tagore's poetry collection. The page she just read was "Life is Like a Summer Flower".
"Are you scared? Sisi."
Now that there were only Yang Ping and Sisi in the ward, he decided to talk to her. Yang Ping was standing next to the cactus.
Sisi smiled, with a blush unique to teenagers on her face: "I used to be afraid, but I'm not afraid anymore. I've read a lot of books since I got sick. The math teacher once told us that we will learn laws called axioms in middle school. The axioms are
If it does not need to be proved, it is correct. I found that there are two self-evident axioms in medicine, or axioms that do not need to be proved. I don’t know if they are correct or not, and I don’t know if there are such axioms in other books.
.”
She could actually summarize axioms, and they were medical axioms. Yang Ping was very curious about what this weird little elf girl was thinking in her mind.
"Tell me what you think and let me see if this axiom is your original creation or an accidental overlap with the results of previous generations." Yang Ping smiled.
Si thought for a while and said, "You can't laugh at me when I say it, and you can't say it's a child's words."
Yang Ping quickly said: "I promise, I won't laugh or talk like a child."
Sisi lowered her head and thought for a while, then raised her head and said, "Everyone will get sick, and everyone will die from illness."
Yang Ping repeated this sentence in his heart, and he couldn't help but be surprised. What a smart little girl. She really gave a very profound philosophical interpretation of the disease from a certain perspective.
Everyone is going to get sick, and everyone is going to die from illness, that’s absolutely true.
Borrowing a commonly used concept in oncology: 5-year survival rate. In a sense, the difference between normal people and patients, or even normal people and cancer patients, is just that the five-year survival rates are different, and they are all less than 100%.
In layman's terms, birth, old age, illness and death are inevitable for everyone. Everyone will die eventually, but the age at which this end point is is different.
At this time, Yang Ping didn't know what to say. He could only use the efforts he was making to give the little girl a glimmer of hope. Even if she didn't need it now, Yang Ping felt that he was a doctor and had the responsibility and obligation to give to terminally ill patients.
A glimmer of hope, even comfort, even care.
"I am trying a new treatment method that uses viruses to carry factors that can kill tumor cells to treat you. Inject these viruses into your body. They are carried by the blood to various places throughout the body and can penetrate the blood-brain barrier.
They can infect those tumor cells and then use the lethal factors they carry to kill the tumor cells. Our viruses have been successfully modified, and these viruses have been cultivated in the laboratory and can be injected into your body soon."
Sisi always kept a bright smile on her face, like an angel: "I said that the eyes are the windows to the soul. I can see from your eyes that you are comforting me. This treatment plan is medically from design to
Clinical application takes more than ten years, and the success rate is pitifully low, often less than one percent, but I am willing to be your experimental subject. I once said that I am willing to be your wrong answer book."
''Have you read any books or papers on this subject?" Yang Ping was very surprised.
Sisi nodded: "Didn't you get me a library card from the hospital? I often go there to read books and magazines, so I know a little bit about it."
"You will definitely be a good doctor when you study medicine in the future." Yang Ping encouraged her, although this was just to deceive her.
Sisi pursed her lips: "I have something to ask you. Have you asked me? I don't know if the remains of tumor patients can be donated to the medical school. If so, I would like to donate the remains to Nandu Medical University as specimens for medical students.
, I said before that I would study medicine with you, but now it seems that I can’t do it. If I can donate my body to Nandu Medical University to be an anatomy teacher, will I enter the medical field in another way and realize my ideal."
Can't empathize!
Yang Ping told himself in his heart, but he couldn't help it, his eyes were already wet.
"Can you agree? This is your last request."
"Can!"
Yang Ping turned to look at the cactus in the corner. He didn't want Sisi to see him crying. He had always been a confident and omnipotent big brother in front of Sisi.
''Are you a professor at Nandu Medical University?"
"Yes."
Yang Ping deliberately lowered his head and played with the cactus.
"Then you will definitely go to class." Sisi looked very happy.
Yang Ping's voice was a little hoarse: "I have one class every week."
"Is it an anatomy class?"
'No, it's "Surgery", taught to senior medical students.'
'That's it...'
Sisi's tone was a little disappointed.
"What's wrong?"
"If you go to anatomy class, then I can listen to your lectures every week..."
Yang Ping took a deep breath, tears streaming down his face, his throat was blocked by something, and he could no longer speak.