Professor Maninstein has not reacted until now. He is sitting in his office in a daze. On the table is a translated German paper pressed by a teacup. This is Yang Ping's paper on K-virus therapy.
As the leader of the German translation team of the journal "Medicine", Manstein completed the German translation of Yang Ping's paper on the first day it was published. This is the immediacy of online paper dissemination, and how can paper papers be
Unable to keep up with this speed of spread, the German-language paper spread crazily in German medical circles that day.
The paper not only spread in the medical circle, but also somehow reached the ears of some cancer patients. Some patients called Professor Manstein’s laboratory to inquire about the details of K-virus therapy and hoped to make an appointment for treatment. The telephone number of the laboratory
He was almost beaten to death, which made Professor Maninstein very speechless.
I have long known that this translation should be done anonymously and that I should not leave my name or the name of the laboratory, so now I don’t even dare to put away the laboratory phone, so I can only pick it up and put it aside.
Professor Maninstein has not yet digested the space-guided gene theory, and now Professor Yang has come up with a K-virus therapy for tumors, which makes Professor Maninstein a little overwhelmed.
What on earth is this? Professor Maninstein is thinking about why it has such magical abilities.
This magical K virus uses recombinant adenovirus to implant a protein structure called k factor. The adenovirus is equivalent to a missile, and the K factor is the warhead of the missile. This missile carries the k factor and is transported to the inside of the tumor through the blood circulation.
Once inside the tumor, the recombinant new viruses can widely infect tumor cells. They release K factors within the cells, just like ordinary viruses release viral particles within the cells.
Once K factor is released, it can initiate the apoptosis program of tumor cells. Using this principle, it can kill tumor cells, and this elimination is with great precision, which is truly a precision treatment worthy of the name.
How amazing!
Professor Mannstein sighed.
Every step is a wonderful idea. For example, Professor Yang's recombinant adenovirus technology is unparalleled. He genetically recombined the existing recombinant adenovirus and eliminated the shortcomings of the original adenovirus.
Almost all of them are avoided, and the advantages are fully utilized, which can be called a model of utilization of carrier viruses.
Originally, adenoviruses like this one have a very high infection rate for all cells in the human body, with almost 100% infection rate. This is the biggest advantage of this virus. Yang Ping took advantage of this. If other viruses are used as
The vector cannot infect various cells, and naturally it cannot infect tumor cells. If it cannot achieve the purpose of infection, it will be impossible to kill tumor cells.
The recombinant virus modified by Yang Ping maintains 100% infection of tumor cells, but the infection rate of other normal cells is reduced, that is, it can distinguish between tumor cells and normal cells, placing tumor cells in
Prioritize infection.
The K factor as a warhead is the weapon that many cancer experts dream of. Many teams around the world are studying the treatment of tumors, hoping to obtain this factor, but Yang Ping easily solved it.
If spatial guidance genes are so mysterious to most people, then the current K-virus therapy is so down-to-earth that almost every professionally trained oncologist can understand it.
Professor Maninstein cheered up and immediately called his assistant: "Book me a ticket to China!"
Originally, he was going to attend Yang Ping's wedding, but now he decided to move forward and see what the real situation of this experiment was like. It was really exciting.
---
Although the current K virus based on adenovirus is not the best configuration, under the current conditions, it must be the best choice. We will slowly look for new configurations in the future. Through these experiments, K virus
The therapy is basically taking shape. Although there are still many imperfections, it doesn't matter.
In the future, we will slowly improve and improve as we go. Sisi Yang Ping has already seen hope and has a sense of confidence. Unlike before, there is no way at all in the existing treatment methods. Traditional treatments include chemotherapy and radiotherapy.
If you continue, not only will it not be cured, it will only accelerate the worsening of the condition.
Yang Ping made a treatment plan for Sisi, injecting K virus regularly, because after the K virus is injected into Sisi's body, even if it successfully infects tumor cells, it will still be hit by the immune system later. Only viruses that can replicate can withstand the blow.
It takes longer, but as time goes by, these viruses are eventually eliminated by the human immune system.
The most dangerous thing is if the human body does not have any immunity to a virus. Once it starts to cause damage, the human body will be unable to resist it. This is why the human body is not afraid of viruses that it has been fighting against, but is afraid of brand-new viruses.
For example, viruses in the frozen soil or alien viruses are the most dangerous once they are infected by humans, because humans have no immunity to this virus and the human body has no experience in fighting it. Once infected, it means death.
Yang Ping's own blood test results have also come out. The virus has been eliminated and no more viruses have been found. It seems that no matter how this virus changes, it still uses the original adenovirus as its main gene, and the gene determines its properties.
, because mutations appeared in Yang Ping's body this time, the immune system needs a certain amount of time to adjust its combat plan and slowly eliminate them.
Now that the virus has been eliminated, Yang Ping is relieved, and so is everyone.
Child Zhao Yufan also received the same treatment as Sisi, because K-virus therapy was also successful on him. Now that K-virus therapy is both safe and effective, Yang Ping plans to recruit a group of volunteers for treatment.
More data can also be obtained, and the new method can bring benefits to patients as soon as possible, allowing some people to receive treatment in advance. If we wait for the real K virus therapy to be launched, I am afraid that we will really have to go through a formal process. Even if we get a green channel,
It will also take two or three years.
This chapter is not over yet, please click on the next page to continue reading! But thinking of the previous turmoil, Yang Ping gave up the idea again. He did not want another similar turmoil to interfere with his scientific research.
Looking at Sisi bouncing around and thinking about these days and nights, Yang Ping felt that it was very worthwhile, especially since this experiment had built up confidence in himself. Even without a system, he could solve problems with his own mind.
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Yang Ping had just planned to go home for dinner after taking a short break, but he received a call from Professor Su.
Nandu Affiliated No. 1 invited Yang Ping for emergency consultation. The patient was a young scientist. He suddenly suffered a strange illness at home while visiting relatives on vacation. He was rushed to Nandu Affiliated No. 1 for treatment. Now he has been admitted to ICU because of his serious condition. Preliminary diagnosis
for rabies.
Rabies has a 100% mortality rate. Perhaps because of the special status of this patient, Professor Su had to invite Yang Ping to the scene.
The emergency consultation could not be delayed. Yang Ping set off immediately and took the time to call Xiao Su in the car to explain the situation. He could not go home for dinner.
When we arrived at the 1st ICU of Nandu, the experts from the 1st ICU of Nandu had already gathered in the conference room to wait for Yang Ping. Everyone looked serious. Director Luo of the 1st ICU of Nandu immediately introduced the patient's condition to Yang Ping.
Extreme fear, fear of water, fear of wind, salivation, difficulty breathing, episodic pharyngeal muscle spasm, difficulty urinating and defecation, excessive sweating, etc.
I was bitten by a wild dog 20 years ago, and I was not vaccinated against rabies at that time.
Yang Ping listened to Director Luo's introduction to the condition while flipping through the medical records.
In the end, the diagnosis given by Nandu Annex 1 was: rabies.
Regardless of the medical history, physical examination or various auxiliary examinations, the diagnosis of rabies is supported, and there is no doubt about the diagnosis.
However, rabies has a 100% mortality rate, and there is no solution under current medical conditions.
Yang Ping decided to see the patient first. He put on an isolation gown and gloves and gave the patient a physical examination.
After watching the patient wash his hands, take off his isolation gown, return to the doctor's office and read the patient's medical record carefully.
Rabies! There is no problem with the diagnosis.
Professor Su said: "This patient is a bit special. He is responsible for a very important scientific research task in our country. This task is in the middle of the process. Without his participation, this project would have been delayed for at least 5-10 years before it could be successful. But now
This project is of vital importance to our country, so our superiors asked us to go all out to save it. We must try our best to save it, and you are called to participate in the emergency consultation."
Originally, Yang Ping was a surgeon and should not participate in consultations on infectious diseases, but his superiors asked him to do so, so Professor Su had no choice but to comply. Professor Su was now under great pressure.
The original intention of the Imperial Capital was to transfer the patient to the Imperial Capital for treatment as soon as possible, but now the patient cannot be transferred at all and can only be treated on the spot.
"This is not another disease, but rabies. No matter where it is, the mortality rate is 100%. There is no way. We can only do our best to let the patients live a few more days. How do you save rabies? Now
It can only be treated symptomatically." Director Yuan from the Department of Infectious Diseases Affiliated to Nandu University was straightforward.
"Yes, there are some things that cannot be changed by human power. Who can break the 100% mortality rate?" Director Luo also agreed with Director Yuan's opinion.
Professor Su said slowly: "Don't be anxious, everyone. The superiors will respect the objective facts and understand us, but even if the mortality rate is 100%, we must make 200% effort."
Yang Ping nodded: "Let me think about it."
In the past, he might not have said this, but after Sisi's treatment, he wanted to try any unresolved problem. Regardless of success or failure, the passion and curiosity in his mind were always ready to move.
Rabies has a 100% mortality rate. What else do you think? Are there any new opinions?
Everyone can't help but wonder what new ideas Yang Ping has. He is a genius, but geniuses are still human beings.
Thanks to the large amount of time the system gave him at that time, Yang Ping used the system space to read a large number of books and papers. It can be said that he utilized the system space to the extreme. He read and studied in the system space for a long time and accumulated a lot of
Regarding medical knowledge, it can be said that no one in the world would read so many books and papers like his.
Yang Ping tapped his fingers lightly on the table. Of course, there was no sound, he just kept a rhythm.
He thought in his mind that rabies usually dies from organ failure caused by damage to the nervous system. The nervous system is damaged first, then organ failure. Yang Ping tried hard to recall the information he had read about rabies, and then summarized and refined them.
Fortunately, at that time, he was fascinated by all medical books, no matter which specialty, he studied a lot. He did not expect that a surgeon would actually participate in rabies consultation.
Current pathological research on rabies has found that brain damage in rabies patients is not caused by the direct attack of the rabies virus on the brain, but rather by complications of the disease.
Yang Ping is thinking about if there is a switch that can suspend the function of the brain, which can protect the brain from complications. It can make the brain sleep while maintaining the normal operation of the patient's immune system. In this way, although the brain has been dormant, the immune system
It is possible to keep attacking the virus.
In this case, while the virus is fighting the immune system, those complications will not be able to affect the dormant brain. If the virus is eliminated, will the brain be able to escape? If the brain escapes, it will not cause damage to the subsequent organs.
Failure, so, is it possible for the patient to survive.
In the past, Yang Ping might have laughed at himself for his naive whims, but now he wouldn't. Wasn't Sisi saved because of his naive whims?
Anyway, rabies has a 100% mortality rate, so what’s the point of traditional treatment methods? It’s better to use something new.
The cause of death from rabies has not yet been fully understood. One of the extremely important hypotheses is the "neurotransmitter disorder" hypothesis. The core idea of this hypothesis is that the biomolecules in the patient's brain cannot be balanced and lead to death. There are already animal experiments
It shows that ketamine, as an NMDA receptor antagonist, seems to be a bridge to balance neurotransmitters in rabies patients.
Thinking of this, Yang Ping felt that he had some inspiration and could form some ideas, but the ideas in his mind were not fully formed yet.
"It's not completely impossible. I have to think about it carefully. I'll clarify my thoughts later." Yang Ping thought about it for a long time and came up with this sentence.
Yang Ping finally understood why he was able to come up with those new ideas during Sisi's treatment. It was because he had acquired a lot of knowledge by reading books in the system space. This knowledge was sometimes connected in series and combined with each other to produce some sparks of imagination.
No, boss, this is rabies with a 100% mortality rate. What can you do?
Everyone looked at each other, if it had been anyone else, everyone would have laughed at it, but Yang Ping and the others did not dare, because this young man is indeed a genius, and she is also the son-in-law of Dean Su.
"You give him symptomatic treatment first and try to help him delay it. I'll think about it carefully and I'll come back later."
Yang Ping's consultation ended like this, and even Professor Su was a little confused.
On the way back from Nandu Medical University, Yang Ping was thinking about this problem while sitting in the car. With 100% mortality rate, can he change his thinking and challenge it? There is no other way anyway, so why not try a new way of thinking? In this case