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0354 Chapter subject

 Yang Ping is quite worried about little Andrew’s surgery.

Although he has drawn detailed surgical drawings, I am afraid that Robert still cannot achieve satisfactory results from the operation.

With Robert's rigor as a doctor, he would definitely not do this surgery rashly. He would either ask Yang Ping to do it, or wait a few years for Robert to become proficient in the surgery before doing it.

Robert should choose the former, because he is a doctor, an outstanding doctor, and he will think from the patient's perspective rather than his own interests.

The most difficult cases in Yang Ping's hands include little Andrew and boss Cheng. There is a patient with brittle knee joints. His surgery was botched in Yunjian and he plans to have it repaired at Liquan Hospital.

Wei Danian, who is admitted to the ICU once a year, has yet to receive a diagnosis. What is the cause of lactic acidosis?

There is no news about the WeChat group specially created to discuss Wei Danian's condition during this period. It seems that Dr. Dawen of Nandu Medical University has not yet produced the results of the genetic test.

Yang Ping has devoted the most effort, and thinks the most difficult thing is Sisi. Sisi's femur has been lengthened by more than ten centimeters. Once it reaches the target value, the two ends will meet, and the next step of surgery will be to reconstruct her thigh muscles.

After multiple resection surgeries for the primary tumor, not only the entire femur was removed, but very little of the surrounding muscles were removed. If the muscles were to be reconstructed, muscle flaps had to be taken from other places for transplantation.

The muscles of the thigh, whether it is the quadriceps or biceps, are the strongest muscles in the human body, and a suitable donor site cannot be found.

This is a thorny issue, but it can be dealt with slowly. Sisi’s last review showed that no recurrence of the tumors treated with Haifu Knife was found for the time being.

But recurrence is a matter of time, and it is almost impossible to remove the spread of tumor cells simply by surgical means.

What should I do if it relapses?

Continue to use the Haifu knife. This kind of fire-extinguishing surgery cannot touch the source of the fire, so you can only run for your life.

But for osteosarcoma, there are no specific targeted drugs in the world. Apart from surgery, radiotherapy and chemotherapy, there is no good method. Relatively speaking, Haifu's focused ultrasound is currently the best method.

Regarding Sisi, Yang Ping had to think further. Subconsciously, he had made up his mind to go all out, no matter what the outcome was, he would not hesitate.

Therefore, the laboratory rewarded by the system space is urgent for Yang Ping. He needs a laboratory for research, just like massive surgical training. With this laboratory, he can establish research projects and spend endless time conducting research.

.

Yang Ping checked the time on his mobile phone. Song Zimo's surgery should have been performed. He got up from the bench and went to the operating room to take a look.

The first operation was stress-free for Song Zimo. The operation was performed strictly in accordance with the standard procedure.

The steps of the standard process actually correspond to each scoring point, and there is no contradiction between the two.

Immediately afterwards, Director Han and Professor Zhang also came in, and they were discussing something.

Song Zimo's surgery was impeccable, every step was neither redundant nor omitted, meticulous but not rigid, and there was no trace of deliberate standardization for competition.

The judges who were watching the live broadcast were scoring step by step, full score, full score, full score---

Director Han and Professor Zhang seemed very relaxed. Seeing Yang Ping, Director Han waved: "Xiao Yang, the stem cell research license of the Orthopedic Research Institute has been issued. If you see any scientific research projects, you can set up one."

Yang Ping really wants to set up a project to do scientific research now. For the time being, he wants to focus on the repair of defective tissues, such as the repair of muscle tissue defects. This is the next step for Sisi to solve.

It’s such a big subject, we’ll wait until we get a system space laboratory later.

"I want to set up a topic in tissue engineering that requires the use of stem cells and 3D printing." Yang Ping expressed his thoughts.

"The orthopedic laboratory is for you to use, and all the equipment can be used at will." Director Han's purpose of building this platform is for young people.

Yang Ping is already very familiar with the equipment inside. The 3D printer can print at the macroscopic level, but not at the microscopic level, and even less at the nanometer level.

This equipment originally had nano-level micro-printing, but when it was introduced, it was a restricted technology and people were unwilling to sell it, thus emasculating the corresponding hardware and software modules.

It’s not surprising that once these cutting-edge devices are introduced to China, these foreigners will emasculate their functions, deliberately reduce hardware and software modules, and compromise functions, euphemistically calling them technical limitations.

After Song Zimo's surgery was completed, the video was turned off, and the scores already given were all full marks.

This kind of surgery is not difficult for any orthopedic surgeon to complete, but it is very difficult to achieve perfect scores.

Mr. Guo from the Department of Traumatology and Orthopedics went to the operating rooms one by one to inform him that he would treat him to dinner that night, unknowingly thinking that Mr. Guo was getting married or had a one-month-old child.

Mr. Guo is single and has not been promoted to a professional title recently. What makes him so happy? He broadcasts invitations to people for dinner.

It turns out that Mr. Guo has ended a year of hospitalization and a life of being on call 24 hours a day for 365 days, which is certainly worthy of celebration.

He wants to set up a few tables near the hospital to celebrate. At the same time, he might as well inform everyone: Those who have sisters, cousins, cousins, and other unmarried female relatives and friends can now be formally introduced to him.

If you don't eat this meal, you won't get it for nothing. Everyone in the orthopedics department who heard the news shouted to have a good gathering in the evening.

Watching Song Zimo finish the first operation for the Golden Knife Award, Director Han and Professor Zhang had nothing to do and planned to leave. Director Han told Yang Ping to come up with the project as soon as possible and he helped apply for funds.

While Yang Ping was free, Takahashi came over and asked, "Can we play tennis together after get off work in the afternoon?"

Yang Ping felt strange that he was playing tennis and playing mandarin duck ball with Baking Soda. Why did you participate in it?

Takahashi smiled and said: "That's not what I meant---"

Then he pointed at Miyuki Fujiwara who was chatting with Xiao Su and asking about equipment.

"It's her, Dr. Fujiwara. She saw you playing with Nurse Su several times in the hospital gymnasium. She asked me to tell you to play tennis together." Takahashi is just a messenger. As for whether Yang Ping agrees, he can

No matter.

"She is a tennis master!" Takahashi added.

Seeing that they were so interested, Yang Ping thought it would be okay to play basketball together: "Okay, Mr. Guo from the Department of Traumatology and Orthopedics will treat us to a treat this afternoon. Let's all have dinner together and then go play basketball after dinner."

After the Golden Knife Award-winning surgery, there were several more surgeries to follow, both performed by Song Zimo and Xu Zhiliang. Yang Ping was also very busy in the operating room.

He just wanted to communicate with Takahashi about tissue engineering and what new research trends there were at the University of Tokyo.

After chatting for so long, Takahashi was still standing. Yang Ping asked him to move a stool to sit down, so he moved a round stool and sat next to Yang Ping.

"In terms of tissue engineering, especially the application of stem cells in tissue engineering, what progress have you made there?" Yang Ping asked Gao Qiao.

Takahashi is very familiar with these and talks eloquently: "Duke University in the United States successfully used stem cells to grow muscles for the first time. The Stem Cell Laboratory of the University of Tokyo followed closely and soon after also grew muscles. These muscles have the characteristics of normal muscles."

The function can accept stimulation and contract."

"They use pluripotent stem cells, inject a large amount of Pax7 protein into them, use these proteins to release signals to the stem cells, and then guide the stem cells to differentiate into muscle cells. Once the differentiation is completed, they stop the injection of Pax7 protein and instead provide the necessary conditions for muscle cell development.

With the necessary nutrients, these muscle cells can maintain stable division and development under the nutritional support. After three to four weeks of culture on the prefabricated nano 3D template, the muscle cells will gather to form muscle fibers. These muscle fibers are similar to the normal muscle fibers of the human body.

It can contract when stimulated, but the intensity and strength are not as good as natural muscles. They transplanted the cultivated muscles into mice and obtained a three-week survival time. During the survival period, they had normal muscle function."

"In the Stem Cell Laboratory of the University of Tokyo, I am one of the main leaders of this project. The key technology lies in the differentiation guidance of stem cells and the printing of nano-3D scaffolds. At present, our common obstacle is that the cultured muscle cells have a long survival time in experimental animals.

Short, our time can be extended to six weeks, twice as long as in the United States, but in the end the muscle cells will still disintegrate. If the mystery of disintegration can be solved, unlimited muscles can be cultivated in the laboratory in the future. On this basis, further

Looking for substances that induce differentiation of various tissues, so that differentiation of any tissue is not a problem. Unfortunately, neither the United States nor we have mastered only one differentiation substance - Pax7 protein."

Takahashi has no doubts about Yang Ping's ability, and he is very eager to establish cooperation with Yang Ping to carry out this project together, because he encountered resistance in this project and was unable to continue to make breakthroughs.

I just learned about the equipment of the orthopedic laboratory from Director Han. The 3D printer does not have the ability to print microscopically. This function has been castrated by the German manufacturer.

Because of these cutting-edge technologies, they need to keep them secret. Currently, only the macro printing function is open. As for micro-printing, they will not sell it no matter how much money they pay. Therefore, this machine cannot perform nano-level micro-printing and lacks physics and

Software modules.

To conduct this experiment, a 3D module scaffold for cultivating muscles is indispensable, which is relied upon to guide the arrangement of muscle cells.

"I want to set up this topic at the Institute of Orthopedics, which also uses stem cells to cultivate muscle tissue. Regarding the problem of disintegration, the problem lies in mitochondria, which is equivalent to the mechanism of cell aging and death. It is just an accelerated version of this mechanism. I set up this topic

, just to solve this problem, you and the Americans have fallen into a dead end---"

In the system space, Yang Ping's knowledge obtained by using massive data is unmatched by Takahashi in terms of breadth and depth.

It's just that Yang Ping has not conducted such experiments so far. If he can cooperate with Takahashi, he can borrow a chicken to lay eggs, which will save a lot of time than starting over by himself.

Yang Ping explained the solution to the problem in one sentence, but stopped talking in the middle of the sentence.

It's equivalent to patting your pocket. There is a sound of keys inside, but you just don't take out the keys: "The keys are here!"

Takahashi is deeply aware of Yang Ping's super high IQ, and he firmly believes that by working with Yang Ping, he can find a way to break through.

However, Yang Ping did not propose cooperation, but simply said that Takahashi and the Americans had fallen into a trap.

"Dr. Yang, if you are interested, can we work together?" Takahashi asked.

Yang Ping seemed to have little interest: "My starting point is relatively high. If we cooperate, I don't want to do those basic things. I am only responsible for extending the survival period of the cultured muscle cells."

"Okay!" Takahashi was very happy. This is what they want and they can never break through.


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