Yang Ping chose to use stem cells to cultivate muscles as a project, not on a whim, but after careful consideration.
If successful, it will be easier to transition to cultivating other organs in the future, such as skin, tendons, ligaments, cartilage, bones, and even joints.
Taking a longer view, we can also develop the heart, liver, kidneys, etc.
The organization technology and equipment for this subject will be relatively more convenient, such as nano-micro scaffolds, which are relatively easy to obtain through Takahashi.
Nano-microscaffolds have very high requirements for 3D printing technology. Their three-dimensional structural arrangement is at the level of cell clusters and must be able to guide muscle fibers into spatial configuration.
This level of 3D printing technology is currently unavailable in China, and the core technology is monopolized by German and Japanese companies.
This is also the reason why Yang Ping seeks international cooperation. It is impossible for one person to break through all industrial technologies. He can only work hard on medical technology.
The obstacle that the United States and Japan cannot overcome now is the collapse of cells. The collapse results from the instability of certain cell structures. There are many unstable factors, including unstable cell membranes and unstable organelles.
Many papers now assume that any one of these collapse factors acts as a starting factor, causing cells to collapse, leading to the collapse of other structures. When observing, researchers focus on one side due to various reasons. It is not surprising. This is the inevitable result of artificially induced stem cell differentiation. When the induction technology is immature, it will inevitably cause some structural instability, which is a potential cause of collapse.
In fact, the cultivation of stem cells in organs is already in full swing.
The University of Tokyo also cultivated the world's first heart, with a diameter of 1 mm and a complete ventricular and atrial blood vessel structure, which is about the same size as a mouse fetal heart.
The National Center for Adult Education in Japan also cultivated a liver; the University of Edinburgh in the United Kingdom cultivated a kidney; and Harvard University in the United States cultivated skin.
These technologies all face a common problem - maturity and stability.
If this problem is solved, these technologies can move from the laboratory to the clinic.
Muscle culture is currently the most mature method and can be transplanted into animals to obtain a survival time of several weeks.
Those internal organs, such as the heart, a small heart with a diameter of only one millimeter, will face the problem of collapse if it is further cultivated, and the small heart will not be able to grow smoothly.
Yang Ping wants to start with muscles to solve the problem of maturity and stability.
Then it extends to skin, tendon, cartilage, etc., which are widely used in orthopedics.
With skin, there is no need to tear down the east wall to patch up the west wall, graft skin or make skin flaps.
With tendons, patients who undergo ligament reconstruction will have better surgical outcomes.
With cartilage, cartilage degenerative diseases, such as senile knee osteoarthritis, can be solved.
Even a joint was grown for joint replacement.
Stem cells are the most promising field in future surgery and will change the history of surgery.
Perhaps one day, a patient like Yu Shuilian can use her own cells to grow a complete lower body, and then perform a transplant operation to connect the upper and lower bodies to restore a complete body.
After get off work in the afternoon, young doctors from the Department of Orthopedics, whenever they have time, go to Mr. Guo’s dinner.
Mr. Guo was generous and set up several tables at the Hakka restaurant next to the hospital. I was so happy that I was willing to bleed like this.
After eating and taking a rest, Xiao Su said that Miyuki Fujiwara invited her to play ball together and asked Yang Ping to go too.
They seemed to have made an appointment a long time ago. They had tennis clothes under their coats and a backpack for their rackets.
Xiao Su usually works in the comprehensive orthopedic operating room, and only interacts with Miyuki during operations. Unexpectedly, they chatted quite well, and Tang Fei, the three of them seemed like old friends.
Everyone rests for half an hour, then goes to the court, etc. It’s almost time for strenuous exercise.
Song Zimo, Tang Fei and Xu Zhiliang returned to the department, Fatty went for a run, Xiao Wu wanted to go home to be with his wife, and Zhang Lin's wife was on duty. He packed a few bags, all of which were his wife's favorites, and he had to deliver them in time.
Yang Ping, Gao Qiao, Xiao Su, and Miyuki went to play tennis. Yang Ping and Gao Qiao didn't change clothes.
Xiao Su pulled Yang Ping: "Mei Xue and I will play a few games, and you can just be the audience."
Miyuki held Xiao Su's hand again: "China-Japan women's tennis friendly match."
Takahashi felt as if he had become redundant, so he followed behind, keeping a certain distance.
However, watching two tall beauties playing tennis is actually quite eye-catching.
The two of them had even booked the venue in the hospital gymnasium in advance. Yang Ping and Gao Qiao simply sat down next to them to discuss project cooperation.
Two stunning beauties playing tennis attracted a lot of attention from the sidelines, and people looked over from time to time.
Both of them were very good at it, and it was very fierce. The fight was indistinguishable, and the score was very tight. It seemed that Xiao Su had met an evenly matched opponent.
Takahashi took the initiative and said: "Dr. Yang, premature cell collapse is a problem faced by all stem cell cultured organs. If it can be solved, this will be an epoch-making progress. If Dr. Yang decides to set up this topic, Takahashi requests cooperation. The University of Tokyo
I am the main person in charge of the research team and have enough say."
"Cooperation can save us a lot of time. I don't want to reinvent the wheel, I just want to tackle the most critical difficulties." Yang Ping expressed his plan.
"If Dr. Yang is willing to cooperate with us, we can share all the early technology, which will save Dr. Yang's time. It will be a win-win situation for us." Takahashi also thinks so.
Currently, the University of Tokyo is at the forefront of this technology, but it has encountered difficulties. Yang Ping analyzed all current papers.
I found that the recent papers from the University of Tokyo all focus on the survival period of cells implanted in animals, and the increase in time, from one day to two days, is very slow.
This shows that they have no technological breakthrough for the time being, but are just continuously improving the original technology.
Cooperating with them will achieve twice the result with half the effort.
Scientific research is similar to navigation. The opening of a new route requires countless trials and errors, constant revisions, and the accumulation of data.
If you obtain the artifact of the System Space Laboratory in the future, you will also need a real-life laboratory to complete the experiment.
This chapter is not over yet, please click on the next page to continue reading!
The data obtained in the system space laboratory can help you avoid detours in reality and even get it right in one step, but it still requires a real-world laboratory to repeat the entire experiment.
Therefore, it is beneficial and harmless to cooperate with these top international universities or hospitals.
The key is how to use and control these resources and be the leader among them. While insisting on independent innovation in scientific research, we must also be open to cooperation, Yang Ping thought.
Takahashi has seen Yang Ping's surgical skills and thinking ability with his own eyes and is convinced of Yang Ping's abilities.
Now I have established a friendship with Yang Ping because of my further training, so I am lucky enough to be able to cooperate with him.
In the future, when Yang Ping's scientific research becomes popular, the teams working with Yang Ping will probably have to queue up, and it will be even more difficult for Takahashi to squeeze in.
Yang Ping was watching the beauty play and thought: "Takahashi, let's cooperate and share the results."
"No problem. I will send a formal email to the University of Tokyo in the evening to obtain authorization to negotiate and sign a contract. We will definitely not be worse than Duke University. Although we used stem cells to grow muscles later than them, we also completed it independently.
, but the paper was published a little later. Compared with them, we are more advanced in induction technology and micro-scaffolding. Their animal survival time is three weeks, and ours is six weeks."
Since Takahashi got to know Yang Ping, he has constantly seen Yang Ping create miracles. He firmly believes that Yang Ping can create miracles if he focuses on the field of stem cells.
From a selfish point of view, Takahashi wants to catch this smooth sailing. As for the conditions of the laboratory and the existing technology, they may be very precious to others, but for people like Yang Ping, even if you don't agree with him
If he cooperates, he can catch up on his own, it just takes a little longer.
If cooperation was proposed at that time, it is estimated that Yang Ping would not be interested at all. If cooperation is proposed now, at least existing technology can be used to help him save time.
After playing a few games, the two beauties were drinking water, chatting and laughing across the net. Both of them were dripping with sweat. The girls in motion are really cute.
After five games, Xiao Su was still stronger and won three games.
Everyone packed up, Xiao Su and Miyuki went back to the dormitory to take a shower and change clothes, Yang Ping and Gao Qiao went to grab a seat, and they wanted to find a barbecue stall for supper.
Yang Ping also called out Song Zimo, Xu Zhiliang, Zhang Lin, Xiao Wu and Fatty.
Zhang Lin is still in the pediatric department and works the night shift with his wife. Xiaowu's home is near the hospital, and the two of them can get there soon.
Song Zimo and Xu Zhiliang were practicing peeling grape skins under the microscope. When they heard there was a midnight snack, they came out without hesitation.
Everyone gathered around and Zhang Lin ordered several boxes of beer. Except for Yang Ping and Song Zimo, all the other men drank.
Several grown men kept talking professionally and continued the topic they just talked about. Song Zimo and Xu Zhiliang also joined in.
The three girls chatted together. Miyuki Fujiwara spoke very good Chinese. From time to time she would come up with interesting Internet slang, making everyone laugh. She would also take selfies with Xiao Su and Tang Fei in her arms and post them on WeChat Moments.
Takahashi drinks very happily. He drinks the glass as soon as he touches it. He also strictly follows Teacher Tang's instruction, no matter who he clinks the glass with, the glass must be lowered by one centimeter.
"When you go to Japan, I'll treat you to Wakayama's Marina Beer!"
Takahashi feels that these Chinese friends are really good. He wants to learn from Abe Nakamaro and write an article about this training, preferably a book, so that the Japanese can also learn a lot.
Those girls didn’t know what they were talking about so happily. They seemed to be talking about which places in China were fun. Miyuki had finally found a good sister in China.
They didn't care what the men here were talking about. They clinked glasses of juice and made plans to go horseback riding on the grasslands of Inner Mongolia, to see the snow-capped mountains in Tibet, and to take pictures wearing Hanfu at West Lake in Hangzhou.
Pairing skewers with beer is so damn fun!
Gao Qiao, Xu Zhiliang, Zhang Lin, Xiao Wu, Fatty, one cup for you, one cup for me, plus two jealous people, the atmosphere is very lively.
"Xiao Gao, okay, do it!" Zhang Lin immediately handed Gao Qiao Man.
"Do it first as a courtesy!" Takahashi didn't hesitate, flipped the cup over and drank it, and he didn't refuse anyone who came.
After finishing his drink, Takahashi stood up and pointed in the direction of the bathroom: "Old men! Wait for me, relax, and come back to continue fighting."
Who taught him this, and all the veterans called him?
Zhang Lin, Xiaowu and Fatty were stunned for a moment, this kid.
