When Joffrey started his remarks, he directly named Chen Nan, without any evasion at all.
However, his words did not offend the people around him too much, and many people even laughed.
"hehe……"
"Hahaha……"
These laughters also did not shy away from Chen Nan.
It seems that, as Joffrey said, the gap between the two is too big, and many people do not believe that China has developed a drug that is comparable to car-t cell therapy.
After all, no matter how many changes in oncology drugs have been made over the years, it seems that they have become a game for these large pharmaceutical companies.
Cancer has also become a stage for everyone to compete with each other.
In contrast, China has been weak in this field for a long time, and this is by no means a fact that can be changed overnight.
People like Qin Shiming in the medical field work hard to negotiate with these companies every day.
Keep prices as low as possible to benefit domestic patients.
It seems...China is lagging far behind in this field compared to India, where generic drugs are prevalent.
actually!
Not so. Why doesn't Qin Shiming understand that he can learn from India and liberalize drug patents?
However, if we let go, we will face a very serious problem: bad money chases good money!
When everyone blindly makes imitation drugs and pirated drugs, this is definitely digging their own grave.
Because this means that the benefits of innovation are too low, and no one will work hard in this industry.
The pharmaceutical industry is definitely not like this.
Therefore, many things must be done by oneself even if it is gritted teeth.
Offstage!
Joffrey's words stung the hearts of many people, especially Yuan Chaomin and others.
In everyone's eyes, what Joffrey was mocking was not Chen Nan, but their country!
While overseas, each of them represents that flag and that country.
However, although what Joffrey said was very annoying, how could everyone not understand that this was the current truth?
Being backward is indeed the current situation.
Yuan Chaomin and others took a deep breath, their faces solemn, and their eyes full of determination and a heavy sense of responsibility.
Lu Shouyue glanced at Chen Nan: "Don't worry!"
"We always have to have someone take the first step!"
Chen Nan nodded. Wasn't that what he was feeling?
at this time!
Joffrey stood on the stage, high-spirited.
Car-T cell therapy is indeed a very top therapy in the field of tumor treatment.
It was born in the context of precision medicine. With the help of genetic testing, precise sequencing and other methods, Gilead overtook the company and became one of the top ten anti-cancer drug companies.
Joffrey smiled and said:
"Improvements in CAR-T cell therapy will not only target cells that have already caused cancer."
"We will strengthen T-cell therapy and develop better early anti-cancer drugs."
"Previously, our CAR-T cell therapy was mainly a survival-prolonging therapy for late-stage cancer."
"but!"
"Now, it's different."
"Our new drug will be combined with the NMPA testing company to establish an early intervention cancer program."
"The purpose of early intervention is to allow the body's immune cells to identify those cells that have lost the control of tumor suppressor genes as early as possible, so as to prevent the disease as early as possible!"
…
Following Joffrey's excited words, the scene was plunged into crazy discussions.
Chen Nan was also a little surprised. Sure enough, the background and technological strength of these large pharmaceutical companies are indeed beyond what we can currently catch up with.
The other party's plan was actually similar to what I had in mind.
I have to say, it’s true that we are enemies on the same road.
The core of the other party's improved car-t cell therapy lies in early intervention and early treatment.
By cultivating special immune cells in vitro, cells with early loss of tumor suppressor genes can be cleaned up!
This is obviously an idea of not treating the existing disease but treating the non-disease.
But……
Is it really possible?
Indeed, on the basis of precision medical gene sequencing, it is theoretically possible to culture T cells in vitro.
Chen Nan didn't understand the core content of precise sequencing before. If it were before today, he would definitely be as shocked as everyone else at the scene by the other party's theory.
After all, if Gilead really manages to intervene in tumor cells early, it could be a great thing.
Offstage!
Many people were a little moved at this time.
Even Guild President Drizzt fell into deep thought at this time.
Professor James Hacken looked solemn and said nothing. He was trying hard to think about the feasibility of this treatment.
The core of CAR-T cell therapy lies in multiple targets, allowing cultured T cells to recognize those tumor cells and carry out self-immunity.
The previous target was to target the nucleic acids of existing tumor cells.
but……
At this time, if they can really achieve early intervention, this will definitely be a great thing for tumors.
Under the stage, heated discussions arose one after another.
"If car-T cell therapy can really do this, it would be amazing!"
"Yes, allowing T cells to improve and successfully identify tumor cells and kill them can be said to strengthen the body's immune function, and it is even much less powerful than the effects of radiotherapy and chemotherapy."
"It's unbelievable that Gilead has such strength!"
"yes……"
In the audience, more and more experts began to discuss and think crazily.
When Joffrey saw this scene, he smiled inwardly and looked at Chen Nan not far away with a bit of mockery in his eyes.
It seems to be saying: Look? See? This is the real strength!
soon!
Someone stood up and began to speak and ask questions: "Mr. Joffrey, at what stage is the current progress of this treatment?"
“How much feasibility analysis do you have?”
This person is a board member of the Cancer Society, and his question quickly attracted everyone's attention.
Seeing this, Joffrey smiled and said:
"Professor, our feasibility, at present, there should be no problem!"
"We have reached a cooperation agreement with NMPA sequencing company to cooperate on early prediction of tumor cell targets!"
"However, it is undeniable that this is an absolutely remarkable progress and a great creation in the history of cancer."
"Currently, our progress is only over 40%, but every day, our scientists are researching and innovating, and our progress is moving forward!"
When Joffrey said these words, the audience burst into applause that lasted for a long time.
No one hates a person who changes the times.
In this new drug launch, every publisher needs to face the doubts of experts in the audience to answer questions and express their opinions.
Likewise, this is also the meaning of this press conference.
After the director finished his speech, people in the audience quickly stood up.
"Mr. Joffrey, I have a question. The biggest problem with CAR-T cell therapy is that the human body cannot tolerate the improved T cells. When the immune response is enhanced, the body's wear and tear will also increase."
"Will this improved therapy cause damage to the human body?"
"Will it cause the body's immune system to collapse?"
Joffrey smiled and said: "That's a good question!"
"Actually, we have already thought of this."
"This is why we found the NMPA gene sequencing company to cooperate."
"NMPA now has second-generation sequencing technology, which is so-called high-throughput sequencing."
"We use physical or chemical methods to randomly break DNA into countless small fragments, probably between 250-300bp!
These DNA fragments were then enriched through library construction.
Next, put the completed library into a sequencer for sequencing. The sequencer has an area where DNA fragments can be attached. Each fragment has an independent attachment area, so that the sequencer can detect all attached DNA sequence information at one time."
"Second-generation sequencing technology allows us to measure a large number of sequences at one time!"
"Making our T-cell therapy more precise."
Joffrey said this and said excitedly: "This will be the true victory of precision medicine!"
"This is the real core of cancer treatment."
Joffrey spoke without caring what other pharmaceutical companies thought.
Maybe, this is the heroism that Americans admire.
They are flamboyant and pursue freedom and the liberation of their individuality.
However, no matter what, Joffrey still aroused fierce applause from the audience.
Joffrey enjoyed this moment very much.
By the time the applause ends, time is almost up. After all, time is very tight for this new drug launch, and the time everyone has is limited.
Chen Nan was not in a hurry, because his time was at the bottom of the queue.
Joffrey smiled and said, "Everyone, does anyone have any questions?"
Secretary-General Oliva glanced at Drizzt: "Sir, the time has come, isn't it..."
Drizzt couldn't help but wave his hand at this time.
Although he had directly expressed his displeasure with Joffrey before, but... one size fits all.
The treatment proposed by the other party is indeed very innovative, and may even lead to a new track in tumor treatment.
Let tumors move from the era of targeted drugs to a new era.
If so!
This meeting will definitely be a great meeting, even a meeting with historical memories.
Drizzt waved his hand: "He can have more time."
That’s right!
This is a double standard that exists everywhere in the world.
Oliva heard the sound and nodded without disturbing.
When Joffrey saw this, he smiled at Drizzt as well.
Everything is left unsaid.
When a person is good enough, whatever he says makes sense.
However, when a person has nothing, even breathing is wrong.
This world is originally a world of double standards.
Joffrey looked at Chen Nan and smiled, with a bit of teasing in his eyes.
He seemed to be saying, yes, it's me, and I'm the one who wants to stop you from coming in.
but……
Do you think I'm afraid of you?
Joffrey actually said it.
He said directly to Chen Nan: "This is Mr. Chen Nan from China."
"Do you think it's necessary for me to stop you?"
"Do you really think I didn't let you in because of fear?"
"No, I simply think that you are not qualified!"
"Oh, by the way, Professor Chen from China, do you have any questions?"
As expected, more people laughed this time!
Everyone looked at Chen Nan, and there seemed to be a complete contrast with what happened in the morning.
James Hacken also had to shake his head helplessly.
This Joffrey is obviously a little too much...
But when someone is good enough, is right or wrong so important?
For a moment, everyone's eyes fell on Chen Nan!
At this time, Yuan Chaomin and others were clenching their fists, filled with anger!
And right now!
Chen Nan suddenly stood up.
Under everyone's gaze, he stood up directly and said to Joffrey:
"Mr. Joffrey, I do have a problem."
This scene stunned everyone.
Chen Nan actually stood up?
this……
What is he going to do when he gets up?
Although Yuan Chaomin and others also wanted to stand up,... Qiao Li's new medicine was really too far ahead of its time.
Joffrey continued to look at Chen Nan teasingly, as if he had found an interesting toy.
"Oh? Please speak!"
Chen Nan got straight to the point and said directly: "Mr. Joffrey seems to be very knowledgeable about second-generation sequencing."
"What I want to ask is, do you know a fatal problem with second-generation sequencing?"
Joffrey's pupils shrank instantly.
because!
This problem is the difficulty they are currently encountering.
Chen Nan didn't wait for the other party to say it, and said directly:
“Next-generation sequencing can indeed measure a large number of sequences at one time!
However, there is a fatal flaw!
Because gene fragments are limited to 250-300 bp, and because they are spliced through overlapping regions of sequences, some sequences may have been tested multiple times.
Moreover, since PCR-enriched sequences are used in library construction, some sequences in small amounts may not be amplified in large quantities, resulting in the loss of some information, and there is a probability that mismatched bases will be introduced in PCR.
This means that there will be a lot of information loss and the error rate will increase a lot!"
After Chen Nan finished speaking, his tone became sharp.
"Just like you said."
"Your improved car-t cell therapy is based on the NMPA sequencing facility."
"Then, good!"
"This will mean that if your company proceeds on the basis of second-generation sequencing."
“Not only can it not be accurately prevented and controlled, it will also greatly increase the burden on the immune system!”
"This is definitely not going to be a good thing!"
"On the contrary, it is a big flaw."
"What I want to ask here is...how does your company want to solve this problem?"
Suddenly!
As Chen Nan spoke such sharp words, the scene suddenly became quiet.
Joffrey on the stage couldn't help but look serious and his eyes wandered.
He really didn't expect that he would meet a master here!
You know, in gene sequencing, second-generation sequencing is still a core secret. How did Chen Nan master the core points of this technology?
There is no doubt that Chen Nan's words were a cruel attack on Joffrey!
to be honest!
When Joffrey came to power, he had even anticipated that Gilead's stock price would skyrocket after today.
With the publication of this conference journal, Gilead will surely become a target of capital chasing.
But!
He never expected that Chen Nan's sudden standing up would really put him in a dilemma.
For a moment, Joffrey felt a little more fearful and uneasy.
If Chen Nan's views are continuously recognized, this will mean that not only will their company not become the target of competition for capital, but its stock price will even fluctuate a lot.
As we all know, pharmaceutical companies are inherently high-risk, high-reward enterprises.
The basis of returns is based on the release of new drugs.
If investment in new drugs fails, they will also face a bloody capital market.
Historically, there has never been a shortage of some large pharmaceutical companies that have achieved glory for a while, but... with the failure of competition in the new drug market, the company will directly fall into a deadlock.
If there is no way to break the deadlock, the company will surely pay a heavy price, or even... go bankrupt!
At this time, why has Gilead not lowered the price of car-t cell therapy?
It’s because they have encountered economic problems in the research and development of new drugs!
Although the NMPA sequencing company is a cooperation, the main investor is still Gilead.
For the research and development of new drugs, they have spent nearly 2 billion US dollars in initial investment.
But!
This investment of two billion US dollars has not brought good benefits to the company's research progress.
On the contrary, he was caught in a dilemma.
Two billion, is that much?
Not much, it seems, for Gilead.
In Fortune's ranking of the top 500 companies in the United States, Gilead Sciences ranks 92nd.
The company’s market value is as high as 100 billion US dollars!
The annual turnover has reached 20 billion US dollars.
but!
Gilead is currently developing five drugs, with car-T cell therapy being a top priority.
According to the latest financial report, Gilead had a net profit of US$5 billion last year.
This seems like a lot, but...it's really not much.
Because their annual investment in scientific research is a huge expense.
Therefore, Gilead’s intention to participate in the new drug launch conference this time is very clear, and it wants to attract capital to enter again.
But……
Chen Nan's words immediately silenced the scene.
Everyone whispered among themselves and began to discuss.
"What Professor Chen said makes sense. Gene sequencing itself is a new field. Although NMPA is indeed powerful, but... as a developing and mature channel, they have no way to provide Gilead's improved car-t
The cells make very good predictions!”
"Yes, this will be a very fatal problem, and even...it will be difficult to continue with this progress."
"It makes sense. If there is no way to reduce the error rate in gene sequencing, there will definitely be problems with this new drug!"
"Well, let me just say, how could this kind of cross-era technology appear now?"
"That's right, it's a gimmick!"
"yes!"
"I didn't expect that Professor Chen knows so much about gene sequencing!"
"Yeah...if it weren't for him, we would all have been deceived today!"
And soon, Chen Nan's words caused many people from the tumor association at the scene to start talking.
Even Drizzt did not expect this sudden turn of events.
He glanced at Chen Nan with some curiosity in his eyes.
And this time!
Joffrey was already riding a tiger.
He stood on the stage and suddenly regretted, was he stupid today?
Can't you go down early?
He already regretted it now. If he had ended it earlier, this would have become another story.
But, what now?
Chen Nan's doubts have already made everyone present and some pharmaceutical companies begin to react.
Chen Nan continued to ask: "Mr. Joffrey, I still want to ask, how does your company plan to solve this problem?"
"If you develop car-T cell therapy based on second-generation sequencing, do you think we would dare to use it?"
"I think, Mr. Joffrey, your qualification should be cancelled, because your new drug has big problems!"
"Moreover, you probably know this, but you still want to stand on this stage."
"Whether a drug with big problems is qualified to stand on this stage, I think, should be a question worth pondering for us!"
When Chen Nan said these words, he immediately aroused warm applause and support from those around him.
Yuan Chaomin, Lu Shouyue and others looked at Chen Nan with wide eyes as if they were reading a book from heaven.
He never thought it would be like this!
Originally, no one had much expectations for Chen Nan to stand up.
But what about now?
Chen Nan gave them a full surprise.
Although they don't know why Chen Nan knows so much about gene sequencing technology, but... they can no longer think about this issue.
Everyone was applauding crazily, but Joffrey on the stage was now in an embarrassing situation and was in a dilemma.
At this time, Drizzt suddenly stood up.
He said to Joffrey: "If Mr. Joffrey hasn't prepared the answer yet, please come down first."
"We have a new publisher next."
These words directly made him lose face.
Joffrey is still a little angry!
"You are so ignorant of scientific progress!"
"You are all scientific researchers, but you lack enterprising spirit and desire to explore!"
"Any progress across the ages requires too much hard work!"
“Don’t back down just because of a little difficulty!”
"Yes, that's right, gene sequencing is a developing subject, but...that's why we need to work harder and explore more firmly!"
Chen Nan doesn't like him!
He directly retorted: "What is the reason to support a technology that is about to be eliminated?"
“Second-generation sequencing inherently has big problems!”
"Even second-generation sequencing will disappear from the stage of history soon!"
Joffrey glared at him: "You're talking nonsense!"
"You have no right to say that!"
"The food and drug supervision currently used by China still uses the NMPA sequencing standard. What qualifications do you have to make such remarks!"
Chen Nan smiled lightly and said, "Oh?"
"It won't be long before you see all the problems with second-generation sequencing!"
“With third-generation sequencing, it’s just a matter of time!”
After Chen Nan finished speaking, he sat down directly.
No regard for what the people around you think.
Yuan Chaomin and Lu Shouyue carefully pulled Chen Nan and whispered:
"Professor Chen, you can't say this nonsense!"
"NMPA Sequencing Company is still an internationally recognized sequencing company."
"Their second-generation sequencing has entered multiple third-party testing by the FDA, including the Food and Drug Administration."
“Even our country is using it!”
"It's easy to offend the other party with your words."
"Isn't your icariin currently accepting applications from NMPA sequencing companies?"
"Be careful they stumble you!"
When Chen Nan heard this, he suddenly frowned slightly. He thought of this problem!
His new drug, icariin, is undergoing testing by a third-party company, NMPA.
Although the application was submitted from China, it is still subject to the other party's company.
However, what he told was the truth.
Such a neutral tripartite institution...
Before Chen Nan came to the United States, the domestic food and drug regulatory authorities sent the drugs to a third-party testing agency to test the sequencing of targeted drugs.
If he releases a new drug at a new drug press conference, he will also need the other party's approval.
Chen Nan thought for a moment and had an idea in his mind.
He is the last one anyway. He asked Kong Xu to send someone to pick it up at noon today. There should be results tomorrow, right?
…
…
The new drug press conference in the morning can be said to be explosive.
The emergence of new drugs one after another made everyone at the scene fall into madness and shock again and again.
But this climax was brought about by Gilead, a company that everyone has high hopes for.
But the final ending was rewritten because of Chen Nan!
So much so, at the luncheon that day.
Chen Nan and Joffrey have obviously become two hot topics.
At this time, Joffrey received a call from Gilead's headquarters.
The other party just vented his anger on Joffrey.
"Joffrey, are you out of your mind?"
"Do you know how much loss you have brought to the company this time?"
"Our liquidity will soon reach a deadlock, and new capital must come in at this time!"
"Why are you confronting Chen Nan? What loss can he cause you?"
"You idiot!"
"Did you know? He is using you to gain power!"
"Chen Nan is unknown, but what is Gilead?"
"You're so stupid!"
The other party vented his anger, causing Joffrey's anger towards Chen Nan to rise instantly.
After hanging up the phone, Joffrey smashed everything in the room!
However, even so, his anger still did not vent.
At this moment, a phone call came in.
Joffrey answered the phone and immediately heard the other party's words: "The new drug submitted by Chen Nan did not pass the NMPA sequencing standards!"
These words made Joffrey as excited as if he was reborn.
Time passes day by day.
And Joffrey became a joke at this meeting.
but……
Just when the meeting was held on the second day.
As Chen Nan came on stage, fierce applause suddenly broke out from the audience.
Everyone gave the young Chinese professor the most respectful ceremony.
Chen Nan stood on the stage, bowed, and smiled:
"Today, the medicine I brought is called akradine, which is a traditional Chinese medicine extract called icariin!"
"Next, I will release a set of data for you!"
"Although this drug has not yet undergone Phase III clinical trials, it has conducted clinical work with a small sample in the hospital."
"Obviously, the effect is very significant!"
"Icariin is a single compound, but it is a drug with multiple molecular targets. It has a remarkable effect on advanced and terminal liver cancer!"
"Next, I conducted a comparison using the icariin data and car-t cell therapy!"
“Everyone can look at the data!”
"Whether it is the reconstruction of immune function, human tolerance, analysis of patients' late-stage quality of life assessment scale, or analysis of improvement in quality of life..."
“We all achieved excellent results!”
"Everyone, please look!"
…
While talking, Chen Nan directly released the experimental data.
"I'm curious why car-t cell therapy has such a high price!"
"The quality of such a drug is simply not worthy of the price of such a drug!"
“I have to admire Gilead’s courage!”
As Chen Nan said these words, there was a lot of discussion in the audience.
This set of data is analyzed and compared in real terms.
Place car-t cell therapy directly on the fire pit.
Joffrey stood in the audience and was extremely angry!
Damn Chen Nan!
It's you again!
[Ding! Congratulations, you received a negative review from Joffrey, and the negative review level has been upgraded to: Advanced!]
Chen Nan saw this and ignored it.
soon!
It's time for questions.
Just when an expert was about to stand up and ask questions.
Suddenly Joffrey stood up.
"hehe!"
"Everyone, wait a moment!"
"I think this Chinese guy is lying, or even a scam!"
"He does not have the ability to develop targeted drugs."
"I just received the analysis form from NMPA's sequencing technology here."
"As far as I know, this drug does not seem to have obtained the three-party identification results from the NMPA company."
"What a coincidence!"
"I have results here."
"Professor Chen, would you like me to read it for you?"
"After testing, icariin and acoradine do not have the molecular level of a targeted drug..."
Such words!
Once again, the scene fell into a state of madness.
Everyone's scalp suddenly went numb when they saw the two people locked in a white-hot stalemate!
They suddenly felt that this meeting was not in vain!
Well worth the price of admission!
Drizzt was also dumbfounded.
This Joffrey actually got the identification results of icariin from the NMPA company directly.
And it...failed?!
He quickly looked at Chen Nan.
But……
He didn't see the slightest panic in Chen Nan's eyes, as if...everything was under his control.
However, Yuan Chaomin and others were dumbfounded.
Didn’t pass?!
No...it really didn't pass?!
Why did Chen Nan offend NMPA?
Thinking of this, everyone felt a little regretful.
Joffrey looked at Chen Nan with a bit of pride: "Professor Chen, I think you are more like a liar!"
"You dare to come to this meeting without even getting the standards from NMPA!"
"Do you think everyone is a fool?"
"What do you have to say!"
Chen Nan looked at Joffrey indifferently, with a bit of disdain in his eyes.
Then, he looked at everyone and said: "Why should my drugs be tested by the NMPA company?"
"hehe!"
"Second-generation sequencing technology has fallen behind."
"They are not worthy!"
…
ps: There are too many things to do today, so I can only postpone it until the evening. Eight thousand words are delivered, and the next part will be more exciting.