Chapter 331 Scumbag! (Thanks to the leader of the Mobai Alliance in Qiancheng)
Chen Nan's words were really domineering.
It completely blinded everyone present!
"They...don't deserve it?!"
soon!
The audience fell into a discussion.
Yuan Chaomin and others looked confused. They looked at Chen Nan, obviously unable to understand Chen Nan's confidence in saying this.
Damn it!
They were really panicked inside.
They came to attend the conference and indeed learned a lot of professional knowledge and new drug concepts.
Yuan Chaomin, Lu Shouyue and others naturally hope that Chen Nan's drug will receive attention and publicity on this platform.
After all, this is the venue for the launch of the world’s top new cancer drugs.
But!
Chen Nan actually started to fire on the NMPA company directly here, saying that their second-generation sequencing has fallen behind and is not worthy of genetic testing at all.
These words instantly made everyone a little annoyed.
Sure enough, soon!
More people began to question Chen Nan.
After all, in addition to experts in the field of oncology, there were also many pharmaceutical companies launching new drugs.
What they got were also sequencing results from NMPA.
A targeted drug must pass sequencing to prove that it indeed has a targeting effect on cancer cells. Only then can it obtain the threshold standard for targeted drugs.
Otherwise, even the name "targeted drug" cannot be mentioned.
After Chen Nan was denied by the NMPA sequencing company, he directly targeted the opponent.
He even said that the other party was not worthy of sequencing.
How arrogant and domineering is this?
In an instant, more and more people in the audience began to accuse Chen Nan.
"This... Chen Nan is too arrogant!"
"Yes, NMPA sequencing company is the current international standard, who has the right to say that others are not worthy!"
"That's right! What qualifications does he have to deny NMPA's sequencing standards?"
"China has not even developed a targeted drug, and it is ridiculous to talk about qualifications!"
"Yes, I originally thought this young man was good, but his tone was too loud!"
…
For a time, more and more people began to question and even criticize Chen Nan's words.
On such a stage, one needs to speak with strength and discuss matters with evidence.
It's not who has a loud voice or a tough tone who is more likely to quarrel.
Seeing Chen Nan like this.
Joffrey, who was originally a little disgusted and angry towards Chen Nan, suddenly laughed at this moment.
He was originally a little worried about Chen Nan's new medicine.
The NMPA company actually directly denied the targeting effect of icariin.
Chen Nan even directly started to retaliate against the opponent here.
This immediately aroused heated discussion, and Joffrey didn't even need to stand up himself.
it's good now!
Chen Nan can be said to be surrounded by enemies on all sides.
No matter how many tongues he has, can he stop so many experts present?
Tilson has some dandruff and numbness.
Damn it, isn't Chen Nan too brave?
Yesterday, he directly criticized Gilead's Joffrey. Today, Gilead's stock price continues to slump.
To know!
Some time ago, Gilead's stock price could be said to be a very rare good thing.
Now it's good, many investors are beginning to hesitate.
The United States can be said to be a country where all people participate in stock trading, and many people’s savings are in the stock market.
Chen Nan's questions about Gilead yesterday were quickly published in relevant medical newspapers and magazines, causing the other company's shares to plummet instantly.
And today!
Chen Nan actually directly targeted NMPA Precision Medicine Company.
This operation made Tiersen's waist tremble a little.
but!
Most people showed strong disgust at Chen Nan's words!
Even Drizzt frowned a little at this time.
Although he doesn't like those profit-seeking pharmaceutical companies, there is no denying their contribution to the development of the pharmaceutical industry.
However, Chen Nan now directly criticized the NMPA, which made Drizzt a little unhappy.
Although the World New Cancer Drug Conference welcomes major new pharmaceutical products from all over the world, as long as they pass the review and have recommendations from regions or countries, they are eligible to enter this conference.
However, that doesn't mean you can talk nonsense.
soon!
Someone stood up.
This is Brooks, vice president of the Cancer Society.
Brooks stood up and looked at Chen Nan and said:
"Professor Chen, your speech yesterday was a speech with suggestions for the World Society of Oncology."
"But that doesn't mean you can talk nonsense!"
"The significance of the existence of NMPA has proven its value. Over the years, the strict review of targeted drugs has become something that the industry is aware of."
"The Food and Drug Administrations of many countries will accept and recognize each other's standards by default."
"I want to know why you evaluate each other so much?!"
"Is it just because you haven't obtained the certification from the other company?"
"If so, you are not a qualified oncology researcher."
Brooks' words attracted the attention of many people, and everyone started talking in low voices.
When Joffrey saw this scene, he was overjoyed.
It can be said that he has no good impression of Chen Nan now.
I wish that the other party would encounter difficulties from everyone.
Chen Nan heard the sound and said with a smile: "Sir, of course I am not talking nonsense."
"NMPA currently uses second-generation gene sequencing technology."
"But my drug, icariin, is a multi-molecule target drug."
"He failed the test, which is a very normal thing."
"In fact, starting from this point, it can also prove the shortcomings and loopholes of second-generation sequencing."
"Furthermore, I was not surprised that it failed to pass the other party's detection!"
"The truly great place of Akela Din lies here!
It is different from the drug synthesis of screening targets and is not a one-way gene target.
The shortcomings of second-generation sequencing are obvious. It cannot accurately predict gene fragments and can easily cause errors!
If it is a targeted drug that screens the target, it can be verified through screening.
but!
Akradine is a multi-target small molecule therapeutic drug!
This means that the detection is very difficult, not specific, and can easily be negated by second-generation sequencing!"
Following Chen Nan's words, the audience fell silent for an instant.
Because more and more people seem to realize that Chen Nan is not aimless.
It's not just nonsense.
The other party really meant what he said.
Currently, the main targeted anticancer drugs are based on screening target types.
Second-generation sequencing can detect it and it seems normal.
Chen Nan saw that everyone in the audience was clearly attracted by his remarks.
I feel happy inside.
he knows!
The opportunity has come.
Chen Nan directly slid the device in his hand, and a detailed flow chart appeared on the big screen!
“Everyone can take a look!”
"This is the specific pinnacle of the drug Acladine."
“The core mechanism is to downregulate the inflammatory pathway!
That is, through the inhibition of IL-6/JAK2/STAT3 and TLR-MyD88-IKK-NFκB pathways, it downregulates the expression of TNF-α, IL-6, PD-L1, etc. to exert anti-tumor effects.
At the same time, through the regulation of MDSC\Tregs cells of immunosuppressive cells, the immune microenvironment can be regulated to inhibit tumor growth."
"This is a path that is very close to the activity of human immune cells!"
"Human immune cells are also a multi-target operating mechanism!"
"The same is true for our Akradine. It does not act on tumor cells simply in the form of a drug!"
"It is through the regulation of immune cells to regulate the immune microenvironment, thereby inhibiting the development of cancer cells!"
"If we really want to say which drug our drug is more similar to, it must be CAR-T cell therapy."
"but!"
"We are different from others in modifying T cells so that they do not meet the requirements of the human body."
"It's about using drugs to enhance the regulation of immune cells and make the body immune to cancer cells!"
The people in the audience are all experts in the field of cancer in the world!
Those who can be invited to attend the meeting are definitely not ordinary people.
On the stage, Chen Nan didn't have any timidity in his eyes, he was full of energy and scolded Fang Qiu.
He ignored the hundreds of experts and scholars in the audience, as well as reporters and media from pharmaceutical companies and professional journals around the world!
Those eyes are full of confidence.
And soon, Chen Nan's words attracted the attention of many people.
They began to follow Chen Nan's thoughts carefully.
At this time, no one continued to blame each other.
When Joffrey saw this, he suddenly panicked.
He vaguely felt something was wrong.
So does Brooks.
As time approaches minute by minute.
Chen Nan's story has attracted more and more people.
And Chen Nanyue said that everyone below was increasingly aware that something was wrong with this matter!
Because... Chen Nan began to gradually lead everyone to think in a new direction!
That’s the problem with genetic sequencing!
That’s right!
James Harken soon realized this.
He even looked at Chen Nan in surprise, feeling that something was not right...
What is Chen Nan going to do?
Drizzt on the side even frowned!
He seemed to have thought of something.
suddenly!
He suddenly opened his eyes and looked sharply at Chen Nan on the stage.
He finally knew what Chen Nan was going to say!
Sequence!
Chen Nan is not just launching new drugs today.
It is undeniable that this drug called "Aceladine" is indeed very attractive.
It’s also a novel idea!
but……
This was obviously not the reason that shocked him the most.
Chen Nan didn't seem to care too much about this drug.
Instead, I am using this drug as an example to guide everyone's thinking and transform the concept!
In normal times, Drizzt would definitely stop it.
but!
At this time, Drizzt is not there!
Because he thought of a special possibility.
That is... where is the result of Chen Nan's guidance?
He took a deep breath, feeling a little excited.
Could it be that... Is Chen Nan really working on next-generation sequencing technology?
That’s right!
Akradine cannot be completely denied under second-generation sequencing. On the contrary, this multi-target drug is easier to identify.
but!
In the current environment of screening targets, it is impossible for NMPA to give Chen Nan a pass!
Because once passed, there will be many problems!
First, the emergence of multi-target drugs will expose the flaws of NMPA!
Second, second-generation sequencing technology is a phased product!
as expected!
As time passes by minute by minute.
Everyone in the audience is at the top level of the oncology field.
Whether it is representatives of pharmaceutical companies, experts from tumor societies present, or bosses of academic journals.
They all vaguely grasped a little bit of something.
That is second-generation sequencing... which seems to be falling behind the current oncology environment.
Targeted drugs are making progress!
This is undeniable.
With the continuous innovation of tumor-targeted drugs, drug resistance is constantly increasing. If sequencing technology cannot keep up, this will lead to a big drawback.
That’s the therapeutic effect!
Targeted drugs have always represented the pioneers of oncology drugs in the world.
But in fact, this is also a huge network compiled.
When the sun rises, all scams will be destroyed.
The oncology pharmaceutical company has obviously reached an agreement with the NMPA testing company long ago.
That is the technical difficulty and mystery that maintains targeted drugs.
But!
As the efficacy of second-generation targeted drugs has become worse and worse, third-generation targeted drugs have gradually entered the market, which has reached the peak and limit of second-generation sequencing technology.
If you go further.
They simply cannot meet the sequencing requirements.
The error rate will be greatly increased.
The difficulty of the fourth generation of targeted drugs is also increasing.
to be honest.
Targeted drugs, sooner or later, will follow in the footsteps of antibiotics.
As the drug resistance of cancer cells increases and nucleic acid genes change, this will lead to the dilemma of targeted drugs.
Precision medicine has already encountered big problems...
so!
With Chen Nan's speech, more and more people realized... Chen Nan might be talking about "third generation sequencing"?!
Thinking of this name, almost everyone's body could not help but tremble.
If that’s really the case!
this……
This is too exciting.
Once third-generation sequencing technology emerges, oncology drugs will inevitably usher in a new development opportunity, which will also lead to a new reshuffle of oncology pharmaceutical companies.
All of a sudden!
More and more people cannot help but wrap up their clothes tightly.
Although the temperature on the south coast of the United States is not cold.
However, even so, everyone in the Rochester Hotel still felt a sense of excitement before the climax!
This is especially true for Yuan Chaomin and others.
Before, they were very curious about Chen Nan.
Even... everyone is a little confused about what Chen Nan is going to do.
but!
Along with Chen Nan's analysis of the drug Aceladine, and as Chen Nan brought out some special information from the third-generation sequencing, it seemed that... a mysterious picture was unfolding!
Lu Shouyue and others looked at Chen Nan on the stage, suddenly feeling strange.
Is this Xiao Chen?
Is this really Xiao Chen who came here from China with them for a new drug launch and is it his first time to participate in such a high-end international conference?
this……
Looking at the audience, how many people looked at Chen Nan with a bit of fiery eyes.
That’s right!
Tilson was filled with excitement.
He is waiting!
Wait until Chen Nan says the words "third generation sequencing".
James Harken is waiting!
Dane is waiting too!
And Drizzt is also waiting.
In the room, hundreds of people almost stood up, waiting for Chen Nan to say the words "third generation sequencing"!
pity!
Just at this time.
Chen Nan looked up at the time and suddenly bowed to everyone!
He smiled and said:
"Thanks!"
"This concludes my report for today."
"Akradine will definitely become a targeted drug with cross-generational significance!"
"because……"
"Keep it secret!"
After saying that, Chen Nan walked straight towards the audience.
And this scene!
Suddenly everyone in the audience was dumbfounded.
this?
That's it?
Is this the end?
Does it fit?
That’s right!
Everyone was dumbfounded.
We have all posed, and our interest has reached its peak...
Did you go down?
I've already taken off my clothes. You show me this?
That’s what it feels like!
Chen Nan suddenly came back and added:
"Today is the launch of new cancer drugs."
"We only talk about new drugs and nothing else!"
"thanks for your support!"
After saying that, Chen Nan walked towards the audience.
And hundreds of pairs of eyes were staring at him.
Although Chen Nan did not say a word about "third generation sequencing".
but!
No one doubts whether Chen Nan understands third-generation sequencing technology!
even!
Many people started to think about it.
Could it be...
Third-generation sequencing is already out?
All of a sudden!
Everyone's souls were unknowingly taken away by Chen Nan.
This resulted in the subsequent new drug launch conference being a little less exciting.
Pearls and jade in front.
Everyone feels that after drinking good wine, the taste is taken away, and then... the taste behind it is always a little worse.
Those pharmaceutical companies are also dumbfounded.
Damn it!
Originally, I wanted to demonstrate this new drug on such a stage.
But……
No one was even interested in asking questions.
We've been preparing for this for a long time, okay?
Can you ask me a question?
Even one question will do!
pity!
Everyone's thoughts are on Chen Nan.
He is just like a scumbag who seduces the minds of all the beautiful girls and then walks away?
Really are……
Scumbag!
Pooh!
…
…
The meeting ended quickly.
This will mean that this new drug launch conference has come to a successful conclusion.
Drizzt came on stage and made a summary.
There is a grand luncheon at noon.
This luncheon is of a business nature.
The experts who come to the conference will have friendly negotiations with pharmaceutical companies here, and at the same time obtain the qualifications for donating drugs, participate in drug clinical trials, and receive recommendations for free diagnosis and treatment.
In the past, Yuan Chaomin and others were generally lonely and lonely.
Compared with other bustling experts, they have only obtained some symbolic qualifications.
but……
This time!
But it's completely different from before.
The Chinese expert group actually obtained an independent banquet restaurant.
The restaurant is as luxurious as a conference venue.
The luncheon hadn't even started yet, but a group of people had already walked in impatiently.
They all left their contact information with Chen Nan and others.
"Professor Chen, nice to meet you. I am the vice president of Pfizer Pharmaceuticals. I think we will have many cooperative projects!"
"We are very interested in your icariin."
"I think we can have a deeper understanding and communicate."
…
"Professor Chen, hello, I am from Johnson & Johnson Pharmaceutical Company..."
"Professor Chen, nice to meet you, we are Roche... I think that if you meet the qualifications of our senior professors to donate medicines, we will give you special rights to donate medicines..."
"..."
…
More and more big-name companies are coming to seek further cooperation with Chen Nan.
These pharmaceutical companies are not stupid!
Their humble purpose has only one purpose.
That is third-generation sequencing.
Almost everyone has a hunch that Chen Nan definitely has relevant information about third-generation sequencing.
Otherwise, it would be impossible to make such a display at the launch site of new drugs.
Chen Nan suddenly obtained the high-level drug donation qualification authorization from almost all pharmaceutical companies.
In the United States, there are many clinical trials. These trials are generally Phase III clinical trials and have a high safety factor.
And, the key is free medical care.
You must know that the prices of these new drugs are very expensive, ranging from tens of thousands to hundreds of thousands, which is very difficult for many families.
However, the quota for Phase III clinical trials is not something that can be obtained casually.
For phase III clinical trials of common drugs, you still need to actively spend money to find people!
However, for those targeted drugs that are very mature and expensive, the opportunity for clinical trials is very rare!
But Chen Nan has a lot in his hands!
These pharmaceutical companies are certainly not stupid.
They just want to get the latest third-generation sequencing information from Chen Nan.
For these large international pharmaceutical companies, opportunities represent future market share!
However, Chen Nan pretended to be confused and did not understand.
And when the pharmaceutical company representatives left.
Only then did Yuan Chaomin have time to eat. He looked at the splendid private room and said with some emotion: "It's unbelievable..."
"All this... is true!"
"How can we be so popular?"
Lu Shouyue smiled bitterly: "That's true."
And Yang Fupeng on the side is the most unlucky winner ever.
When we learned that Yang Fupeng was brought by Chen Nan, he was originally not qualified to donate medicine.
But he gained the qualification second only to Chen Nan!
When Yang Fupeng said this, he felt like he was in a dream.
Damn it!
The feeling of holding my thigh is really comfortable.
Hug more in the future...
Yuan Chaomin suddenly lowered his voice at this time and said to Chen Nan:
"Professor Chen, do you really...understand that?"
Chen Nan was stunned: "What?"
Yuan Chaomin was tickled by Chen Nan: "That's it!"
"The one you were talking about! Sandai!"
"Three generations!"
Chen Nan smiled: "Keep it secret!"
Suddenly, Yuan Chaomin lost his temper and started eating angrily.
The food is delicious!
He ate very quickly.
However, he soon discovered that eating quickly was a good thing.
Because soon, an endless stream of experts came to talk to Chen Nan and left their contact information...
Chen Nan didn't refuse.
But when he saw those experts who would rather not attend the meeting for his sake, and those experts who helped him speak.
In the remarks column, there is an additional special symbol.
Wait until the luncheon is over.
Yuan Chaomin and others were about to return to the hotel.
However, Chen Nan was personally invited by Drizzt to chat in the room.
Straight to the point, Drizzt took out an invitation letter!
"Professor Chen, I would like to invite you to join the World Oncology Society!"
"However, according to our rules, there is no way for you to be directly elected to the council."
"So, we can only give you a membership invitation letter."
"At the same time, he was awarded the title of Honorary Director of China Region."
"Our Cancer Society needs talents like you."
Chen Nan was stunned for a moment!
"Is this...appropriate?"
Drizzt smiled slightly: "We, the World Cancer Society, serve patients, and ability is the only criterion for testing!"
"And you have such ability!"
Chen Nan smiled and did not refuse.
After the two chatted for a long time, Drizzt still couldn't hold back his inner curiosity and asked: "Director Chen, third-generation sequencing... do you really know anything about it?"
Chen Nan looked at Drizzt, nodded, and smiled slightly.
Then he turned around and left!
Drizzt was left standing in the room without turning around for a long time!
really have?!
real!
Drizzt was very excited.
…
…
End of the meeting,
The last day is still a reception for pharmaceutical companies.
As for Shen Guzhang, here he saw his son after the operation.
He looked at Shen Yuzhe who was lying on the bed, staring blankly out of the window, and felt extremely distressed!
This blow was too serious for Shen Yuzhe.
The surgery was a success!
Eighty percent of Shen Yuzhe's tongue was removed.
Although tongue reconstruction surgery was performed,... a prosthesis is a prosthesis after all.
From now on!
The world's delicacies have no chance with him.
Sweet and sour, farewell.
Even talking...
It has become very difficult.
all of these!
For Shen Yuzhe, it was a big blow.
Shen Guzhang was about to speak when he suddenly saw Shen Yuzhe holding a newspaper in his hand!
"Rochester Special"
This is a very famous local media.
And the key!
On the cover, there is a young man, majestic, sharp eyes, and full of confidence!
But the title is like this!
"The mysterious Chinese medicine genius from the East made a blockbuster appearance at the world's new cancer drug launch conference!"
In China, even the UC editorial department would not be able to report such a headline.
But!
In the United States, it has attracted a lot of attention.
Chen Nan's demeanor at this meeting was immediately known to many people in the United States.
When Shen Guzhang saw this scene, he was extremely angry!
He quickly picked up the newspaper and was about to throw it away.
But he was suddenly grabbed by Shen Yuzhe.
"Son, don't worry!"
"There is a dad!"
"don’t worry!"
"I remember this grudge..."
Shen Yuzhe's eyes were empty, as if he had lost his soul.
And he slowly turned around and looked at Shen Guzhang, tears streaming down his face.
He had too many grievances that he wanted to vent.
I originally thought that this time I came to the United States, I would be able to defeat Chen Nan very well.
But who would have thought?
However, Chen Nannan attended the meeting, and at the meeting site, Joffrey was defeated in Maicheng, the stock price was depressed, and faced with the NMPA's doubts, he even angrily criticized the other party, causing the other party to reach a deadlock.
The key is that the new drug he came up with was released and became a blockbuster.
They even took out some information about third-generation sequencing, which attracted everyone.
If anyone is the most dazzling person at this year's new drug launch conference, I think it is Chen Nan!
the next day!
Award ceremony!
Sure enough, it was as expected by everyone.
Chen Nan won the honor of this year's Most Anticipated New Drug Award.
This title is equivalent to this year's best performance award.
However, no one doubted or questioned the award given to Chen Nan.
Now, many people are speculating that Chen Nan has really mastered third-generation sequencing technology?
Not just them!
Even in China at this time.
Qin Shiming and others held an emergency meeting to discuss issues with third-generation sequencing technology.
Because it started yesterday!
Qin Shiming received no less than fifty phone calls one after another.
All come from major pharmaceutical companies, as well as some cooperative countries and friendly academic exchange countries.
Their problem is only one!
That's the problem with third-generation sequencing.
This question directly stunned Qin Shiming.
I'm even a little confused as to what's going on?
Until later!
Only then did he know the truth.
Qin Shiming was also a little confused.
Has Chen Nan really mastered third-generation sequencing technology?
What if this is true?
This is awesome!
Qin Shiming thought of this and quickly called Chen Nan!
Asked straight to the point:
"Xiao Chen, do you know third-generation sequencing?"
Chen Nan responded tactfully: "Well, understand a little!"
Qin Shiming, who heard Chen Nan's reply with his own ears, suddenly became excited.
"good!"
"OK!"
"This is a big deal!"
But what Chen Nan said next made Qin Shiming stunned.
"But... Mr. Qin, this technology is not mine."
"It belongs to one of my partners."
"The other party is a research institute established in the United States. It has conducted research on third-generation sequencing relatively early and has achieved results now."
"But...I don't have enough say."
Chen Nan's words immediately made Qin Shiming stunned and even a little disappointed.
actually!
There is a reason why Chen Nan said this.
The new drug Akeladine that was released some time ago attracted the attention of those crazy bees and butterflies.
He even resorts to any means necessary!
He couldn't even imagine that if this technology was brought out, would there be more powerful forces taking action?
Chen Nan is patriotic!
I also want to contribute to the country.
However, he wanted to ensure his own safety first, and he hoped to have chips in his hand.
Moreover, as a genetic testing company, he can openly discuss cooperation with the country.
Hua Ran, if the operation is better.
It may even become a trump card in Chen Nan’s hands!
That's why he made these remarks.
"Can you contact him?"
Chen Nan nodded: "Okay!"
After Qin Shiming heard this, he became excited.
"good!"
"OK!"
"By the way, Xiao Chen, congratulations on winning the honor of the most anticipated new drug."
"Come back, I'll give you a celebration banquet!"
Chen Nan smiled and nodded: "Thank you, director."
…
the next day.
Chen Nan was about to return to China when he received a special invitation.
The inviter is Dane's teacher.
Chief oncologist at Mayo Clinic in Rochester.
Mr. Nelson!
This person is also the Vice President of the World Society of Oncology.
Chen Nan looked at the time and saw that he had an evening flight in the afternoon, so he was not in a hurry.
The other party's invitation was to ask Chen Nan to help diagnose and treat a patient.
Chen Nan was personally invited by Dane.
In this regard, Chen Nan did not refuse.
"Okay, just pick me up tomorrow."
Dan En heard this and smiled gratefully: "Thank you very much, Professor Chen."
"Also, congratulations on joining the World Society of Oncology."
Chen Nan couldn't help but smile and smiled.
"What's the point of congratulations?"
"Professor Dane is already a member of the association."
Dane shook his head: "No, there is a big difference."
"The Cancer Association, being invited by the president, is very valuable."
Chen Nan asked curiously at this time: "By the way, who is the patient?"
Dane suddenly said: "Chinese-American."
"The old gentleman is very old."
"Professor Nelson would like your help."
Chen Nan became even more curious.
…
ps: I would like to thank the leader of the "Only a Thousand Cities of Ink White" leader for his generous reward of 100,000 and becoming the 20th leader of this book. Thank you very much!