p<0.05 and p=0.05 were originally something not worth paying attention to.
It is easy to be ignored, because this matter is not worth studying, and many research institutions even think that p≤0.05 is acceptable!
But Bai Ye happened to encounter such an extreme probability event.
Of course, even p<0.05 does not mean that it is definitely effective, it can only mean that there is a 95% possibility that it is good!
Therefore, returning to statistics, all this is a matter of probability. Even if an error occurs, it may be a type I error or type II error or even a small probability error event.
Bai Ye took a deep breath and continued to start a new round of calculations.
Is it a type I error or a type II error?
Bai Ye was about to start calculating when he suddenly found an aunt standing beside him and said, "Young man, why don't you go back so late? The library is closed."
Bai Ye looked at the time and saw that it was half past ten. He looked at his aunt and quickly said sorry.
Such a familiar scene... It was this aunt who closed the library when I was taking the postgraduate entrance examination, right?
Bai Ye returned to the dormitory and did not do anything else, but carefully looked at the lost data.
This data is not much different from other data. Maybe at that time, you thought that losing it would not have much impact?
Bai Ye didn't know how to think about this kind of thing, so he consulted Karis and Daisy about p=0.05.
They believe that this probability is very small, and they may be able to reduce it by using another calculation method, or they may propose some unnecessary data.
But Bai Ye feels that this kind of real data can often reflect problems, and what is obtained after excluding it is not perfect!
what to do?
Why did Bai Ye struggle with this issue? Because in the first place, this issue might have been the reason for the failure of the experiment.
First of all, it may be because of the results of this animal experiment: in fact, this drug cannot change or reduce the incidence of tumors.
Another possibility is that although this drug is effective in mice, it has no obvious effect on humans.
The main purpose now is to prove these two points.
Bai Ye thought about it all night, and got up at dawn the next day and went to the same location in the library.
He suddenly remembered that when statistics reached level 6, many new testing methods became available.
Bai Ye had never tried these methods, so he reorganized the data and started calculations according to the new model.
Not long after, Bai Ye calculated the result!
But the result left Bai Ye stunned!
is effective!
This drug is effective against digestive tract tumors in km mice...
So why is there such a series of impacts?
Will it even speed up?
Could it be that km mice are not very effective in experiments on digestive tract tumors?
Has no one studied the fit between mice and humans?
Generally speaking, km mice are often used to study tumors. Is it unreasonable? Especially in the direction of digestive tract tumors, is there a problem?
Bai Ye suddenly remembered his copy of "Rat Raising Experience" by Sakr. Bai Ye quickly opened the virtual screen and checked it.
Is there... is there...
Bai Ye is a little excited. If it can be confirmed...this is a new discovery!
km mice are not suitable for the study of digestive tract tumors. Once this theory is confirmed, it will definitely be a big discovery!
Found it! Found it!
Thacker wrote a sentence in his experience: km mice will change their DNA transcription sequences in specific experiments for certain drugs. They are special targeted drugs. They are only applicable to km mice, but not to humans. Humans
The experiment ended in failure...
Bai Ye suddenly realized!
Is that so?
What drug is it? What is the reason?
Bai Ye quickly continued to look through it and found that the DNA sequence of km mice was relatively adaptable. When faced with some strong stimuli, it could mutate faster than humans?
Then he gave many examples to prove some shortcomings of km mice. The article also concluded that the original experiment caused some data gaps due to the loss of original data.
In fact, that is an opportunity to further improve the km experimental mice. If the cause of that mutation can be eliminated, perhaps it will be perfectly suitable for modern tumor research.
Bai Ye was stunned and quickly flipped up to read the name of this experiment: Dr. Mikasu Tranly's research on the use of a synthetic compound to target single-cell cancer.
Dr. Mikasu Tranly?
Bai Ye got up and walked to the toilet. He didn't care about the time and dialed Keao's number directly.
But he calmed down and breathed: "Hello? Keao, are you busy lately?"
Keao's voice was lazy: "Oh! Bai Ye, what time is it now..."
Bai Ye then apologized: "I'll calculate some of your data. By the way, what's the name of your instructor?"
When Ke Ao heard Bai Ye's words, he immediately woke up: "What? There is some result? What result?"
Bai Ye was stunned for a moment, shook his head, and continued to ask: "A little bit for the time being. After I have the results, I will tell you who is your mentor?"
Keao sighed: "I am... Mikasu Tranly! However, the old man is gone... he committed suicide due to depression."
Bai Ye was stunned. It was indeed him, but...why he committed suicide: "Sorry, thank you, wait for my good news."
…………
After chatting with Keao for a while, Bai Ye hung up the phone. He couldn't tell Keao to complete the data himself, but he could study it as the data was correct.
Since the data is correct, there is a problem with the mice, so what is the problem?
Bai Ye returned to the study of the second part of the data, and it was still the key missing data...
Bai Ye spent the next day doing calculations.
Bai Ye is very experienced in digging along the data, and this is not the first time he has done this.
On the third night, Bai Ye looked at the data excitedly, and there were results!
Mainly combined with the first phase data, the results prove that in a molecular sequence, a guanine can easily change the structure of its DNA during RNA transcription!
If the guanine in the km mouse can be deleted and its original DNA sequence is changed, the rate of mutation can be slowed down.
In this way, it is not conducive to the mutation of mice, but it is good for experiments!
Bai Ye was a little excited.
I am destined to be the one who creates history...
Bai Ye was extremely excited just thinking about the new type of mouse, which was suitable for tumor research.
Now we need to experiment. If the experiment results... I, Bai Ye, am destined to be the man who becomes the Rat King...
Although the name is not pleasant, but...
Any kind of work, done to the extreme, is art!
Moreover, now Bai Ye is still shouldering this scientific mission, and it is a mission with rich rewards!