Makalite frowned. This question undoubtedly questioned his answer, and the research and expression of genes were indeed full of randomness. It was not easy for him to answer this question.
"These are two issues. The adaptability and stability of the mouse have nothing to do with it. It may be related to its own expression. I think this student should go back and make up for the lessons. As for the issue of genetic engineering, you
Is there anything else you want to ask?"
After Makalite's words came out, discussions immediately started among the following.
Even Zhang Shulan frowned. This was obviously a quibble. Gene expression is the cause of adaptability, and adaptability is the result of gene expression.
Makalite obviously couldn't answer Bai Ye's question, but he couldn't explain the problem, so there was no way to explain why shr used wistar mice instead of other types of mice such as sd or km.
Or... he didn't engage in research in this area at all, but just made up the answer.
Zhang Shulan thought of this and looked at the young Bai Ye with interest.
Bai Ye said lightly: "Can I think that the priority of shr may not be able to withstand the market test, or we can try to use other mice to conduct research to see if gene grafting can obtain a new type of
Mature essential hypertensive mice?"
When Makalite heard this, he immediately said with a straight face: "Any experiment requires results and data to prove. SHR can persist for several years and is widely recognized internationally. It has the meaning of its existence. No doubts can be raised."
It needs to be supported by data and experiments. If not, your words are just a meaningless argument."
After saying that, Macalette stood up and left.
This meeting broke up on bad terms, and Bai Ye undoubtedly ruined the launch of Lonka SHR's new product.
But Bai Ye has gained a lot. He feels that he has found a direction, which is to start with shr mice and study km mice. Maybe he can find the mechanism for gene expression.
Since shr has lost 100% of its anti-hypertensive gene after so many generations of development, but km mice have it, it means that there is something in the km body that controls the gene expression of km mice.
Dong Cunguang looked at Bai Ye and gave a thumbs up.
"You are so awesome!"
Bai Ye smiled. He was not trying to argue, he just wanted to gain some knowledge.
The two stood up and were about to leave when Zhang Shulan stepped forward.
Bai Ye was a little surprised. He had listened to Zhang Shulan's lectures, which were very simple and without any academic exaggeration.
"Professor Zhang?"
Zhang Shulan smiled: "You are very good, you are doing genetic engineering? What is your name?"
Bai Ye shook his head: "I am a medical student, my name is Bai Ye."
Zhang Shulan's eyes lit up: "That Bai Ye who scored the bpfh rating?"
Bai Ye didn't expect that he was so famous: "Yes."
When Zhang Shulan heard this, she immediately raised her eyebrows in surprise and smiled happily: "You are Bai Ye, the proud disciple that Mr. Liu praises all day long!"
Bai Ye was stunned for a moment, a little confused, what's the situation?
Zhang Shulan then smiled and said: "Isn't your mentor Academician Liu Boli Liu? I praise you all day long, and I wish I could talk about you and say how outstanding you are! When I heard what you said today, I also believed it. You are indeed an outstanding person.
The young man!"
Bai Ye scratched his head awkwardly and said thank you. Then he remembered that the teacher was also an academician of the Chinese Academy of Sciences, and he probably knew Professor Zhang.
Zhang Shulan said seriously at this time: "Actually, the idea you proposed is very good. Our research on mice has always been based on the latest foreign reports. We have been learning and have never questioned it. Your idea is worth giving a try.
Yes, this is my phone number. If you don’t understand anything, come to me at the Chinese Academy of Sciences."
With that said, Zhang Shulan read a series of phone calls to Bai Ye and left with a smile.
Bai Ye looked at Zhang Shulan's leaving figure, suddenly remembered something, and said quickly: "Teacher Zhang... don't tell my tutor that I am studying mice again..."
When Zhang Shulan heard the figure, she almost sprained her feet, then laughed and walked away.
Bai Ye sighed, hey... he was going to be scolded again for not doing his job properly.
Dong Cunguang's face was red and he pulled Bai Ye with some excitement: "Zhang...Zhang...Professor Zhang actually left you a phone number!"
Bai Ye hummed: "Yes, you heard it too, didn't you remember it? I'll go back and give it to you. Do you know Teacher Zhang?"
Dong Cunguang said with a shy face: "She is my idol, and many of her thoughts have a great influence on me. I have always hoped to take the doctoral examination of Teacher Zhang..."
Bai Ye sighed: "Then you don't want to say hello?"
Dong Cunguang said awkwardly: "I am too nervous to speak. I am afraid that I will leave a bad impression on Teacher Zhang if I stutter."
Bai Ye: "..."
At this meeting, Bai Ye felt that the 1,000 yuan was well spent. He had a few meals, stayed in a high-end hotel for two days, challenged an international celebrity, met a domestic celebrity, and came up with a research idea.
Overall, Bai Ye gives himself full marks.
Back in the laboratory, Bai Ye started researching along the original idea.
I checked the information, especially on some basic subjects such as mouse anatomy and physiology. Fortunately, one method can be used to solve all problems, and the progress is still very fast.
One morning at the end of July, Bai Ye couldn't believe it. Could it be that he had found it just like this?
However, it is a bit too incredible.
Why do you say that this is just an ordinary base, guanine, on the double helix structure of mouse DNA?
This thing can actually affect the expression of genes and achieve a special mutation during transcription?
Bai Ye couldn't believe it. In order to confirm, he directly found the drug that was originally tested and wanted to test it.
Three days later, Bai Ye finally completed the verification and came to a conclusion!
Under special circumstances, this guanine may have a certain chance of causing mutations in RNA, resulting in variations in gene expression during translation!
This is an expression of the adaptability of mice in certain special environments.
Of course, this does not mean that all gene expression is related to the guanine in mice, but that the presence of this purine will affect the stability of the mouse gene structure and achieve variation under certain special circumstances.
Bai Ye quietly looked at the laboratory in front of him and took a deep breath.
This should be the main reason why Keao's experiment failed. When the mice were stimulated by that drug, guanine mutated, causing changes in the DNA molecular structure, transcription and translation processes, inhibiting the reproduction of tumor cells.
.
The ultimate reason is guanine!
The mystery that had been unsolved for decades finally had a reason. Thinking of this, Bai Ye sighed with emotion. If the mouse experiment had failed, it would not have been used in the first phase of clinical trials, and those patients would not have died.
Bai Ye sighed, maybe science develops in dialectics, maybe one day Newton's laws will be overturned?
Bai Ye smiled, wrote an answer in his notebook, organized the data, and put it in his bag.