In the Virology Laboratory of Nandu Medical University, the K virus has been cultured, and the follow-up work is being carried out in an intense and orderly manner. For this experiment, the researchers worked overtime to meet the deadline. They cherished this cooperation with Professor Yang Ping, because Yang Ping was in
Everyone already has a god-like figure in their hearts.
At this time, the researchers' faces were filled with joy and excitement, but their actions were extremely cautious. They knew that this time was different from the past. Although the source virus was a safe virus that was harmless to humans and animals, this time the virus would directly
For human experiments, a little carelessness may endanger the safety of the experimental subjects. Therefore, they always maintain a high degree of vigilance and concentration to ensure that every step is accurate and try to avoid mistakes.
K-virus samples will undergo a series of tests. During the test process, researchers need to constantly observe and record data, and analyze the test results. Their eyes are firm and focused, and every small change in the data tugs at their heartstrings.
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After standardized testing, the K virus met the laboratory conditions, and everyone breathed a sigh of relief. Everyone knew about Professor Yang's urgent time requirements for this experiment, so everyone tried their best to cooperate, hoping that Professor Yang's work would not be delayed.
experiment.
Viruses that pass the test will enter the encapsulation process. The encapsulation process is extremely strict. They will seal a certain amount of virus into special biological preparation bottles in a sterile environment, make bottles one by one, and then label them.
Stored in refrigerators, just like vaccines, their storage and transportation process is a traceable cold chain.
The moment these K-virus biological agents that could be used in clinical trials at any time were produced, the atmosphere in the laboratory reached a climax, and the researchers cheered and celebrated each other.
Regardless of whether this clinical trial is a success or a failure, they have taken a new step with Yang Ping. They will be the first in the world to artificially create protein factors that can initiate tumor cell apoptosis by chimerizing them with carrier viruses.
They have developed a brand-new virus, which is the first virus in the world that can kill tumors. This virus also creates a separate category in classification. Regardless of success or failure, their current work is to open up a new field.
As participants, they were of course very excited.
Professor Zhang Zhiwei put these preparations into the storage portable refrigerator with his own hands through the goggles of protective clothing. In the past few days, Professor Zhang has been thinking about Yang Ping's aggressive and time-consuming laboratory methods. In fact, it is not all shortcomings. If not
Considering other factors, objectively speaking, this method also has certain advantages.
According to the regular procedure, computer simulation experiments are first followed by animal experiments, then phase I, II and III clinical trials, and finally clinical application. Now Yang Ping directly applies the virus to patients. In fact, he is not simply taking a blind risk.
, but a very comprehensive assessment of this virus has been made, and the probability of a risk event is very small. The patient receiving treatment is in a very urgent condition and has no time to wait. This is the only possible effective method for her.
Considering both aspects and comparing the risks and benefits, Yang Ping's choice is undoubtedly very smart. The immune systems of animals and humans are different, and the immune mechanisms are not exactly the same, so the data accumulated in animal experiments can be transferred to humans.
If you want to talk about risks, there are still very big risks in conducting experiments. So even if you follow normal procedures, clinical trials from Phase I to Phase III still face risks, but this risk is in compliance with regulations, and the risks Yang Ping is facing now are not.
Compliant.
If we remain absolutely rational, even if the patient does not do the K-virus experiment now, she does not have much time left. Even if the K-virus experiment fails, the most authentic and valuable data can be obtained, and she can immediately learn and modify it. In fact, it is successful.
The probability is still very high.
After thinking about it for the past few days, Professor Zhang Zhiwei felt that Yang Ping's cooperation with him in this experiment was like pie in the sky. If Sanbo Hospital did not have a P3 biological laboratory, I am afraid that such a good thing would not be his turn.
His team just helped him cultivate the virus and became the main participants in the experiment. This kind of experiment, regardless of success or failure, can occupy a top position in the academic world.
Thinking of this, Professor Zhang couldn't help but feel a sense of shame that he had done nothing but passively shared Yang Ping's academic achievements for no reason. From another aspect, it can be seen that Yang Ping is also a scholar who doesn't care about these false reputations.
, he only considers experiments from an objective perspective and never considers things like false reputation. Professor Zhang respects Yang Ping from the bottom of his heart.
But these young Ph.D.s are very happy about this. What does it mean to participate in this experiment? It means that they may hold CNS papers in their hands after graduation. It means that they may complete in just a few weeks what others cannot complete in decades.
Academic accumulation.
After the K-virus preparation was packed, Professor Zhang Zhiwei and two doctors personally escorted it to Sanbo Hospital.
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I had just finished my shift in the early morning, and the special bus from Nandu Medical University had arrived at Sanbo Hospital.
Professor Zhang Zhiwei personally carried the box containing K-virus biological agents. Accompanied by two doctors, he came to the independent ward of the Institute of Surgery. This ward was specially opened for Sisi to facilitate her clinical experiments. Yang Ping
No matter the cost for this experiment.
Yang Ping took the box and carried it to the treatment room in the independent ward. Here, Sisi and the doctors and nurses had been waiting for a long time. Sisi had made all preparations.
In the treatment room, Sisi was lying quietly on the hospital bed, with her eyes closed and breathing evenly. Her left arm had been prepared for the indwelling needle, and her body was connected to the wires of various monitoring instruments. All kinds of rescue equipment were also in place.
Keep it lying around, ready to be used at any time.
She waited quietly for the start of this new treatment. Although the outcome was unknown, she was mentally prepared for the worst, so everything seemed so peaceful.
This chapter is not over yet, please click on the next page to continue reading! "It's like an injection, don't be nervous." Yang Ping comforted her.
Sisi said in a calm tone: "I'm not afraid."
The ECG on the ECG monitor showed that she was indeed not afraid because her heart rate was still within the normal range and very stable with no obvious fluctuations.
"Can we start?" Professor Zhang Zhiwei asked.
Yang Ping nodded: "Start."
The portable refrigerator was opened, and Professor Zhang Zhiwei personally took out the K-virus biological preparation from it. This preparation has been designed as a disposable syringe device. When it is taken out of the sealed sterile packaging box, it can be directly connected to the indwelling needle on Sisi's arm.
, and then it can be used directly as a syringe to inject the K virus liquid inside
When injected into the veins, the K virus enters the heart along with the blood circulation in the blood vessels, and then distributes throughout the body through the arterial blood. They will selectively infect tumor cells and then parasitize in the tumor cells. Once the infection is successful, they will initiate tumors.
The cell apoptosis program allows tumor cells to die quietly.
The whole process is perfect from a theoretical point of view. But theory is theory and practice is practice. How many drugs and treatments seem perfect in theory, but after clinical testing, they are ultimately useless and are eventually cruelly eliminated. Treatment
No matter how comprehensive the method is in the theoretical stage, it is far inferior to the complexity of the human body in reality.
A nurse was assisting beside her. She straightened out the indwelling syringe on Sisi's arm. Yang Ping connected the preparation device to the syringe. When he was about to inject it, he hesitated, looked at Sisi, and did not inject it immediately.
Sisi may have felt something. She opened her eyes and raised her head slightly, and saw Yang Ping who had not yet made a move: "Don't worry, I'm not afraid." After saying that, she made a naughty face towards everyone, and the atmosphere in the treatment room instantly changed.
be alleviated.
Originally, Song Zimo, Xu Zhiliang and many doctors next to them had serious faces, but just now they were so amused by Sisi's grimace that they couldn't help but laugh. This little girl was so relaxed.
This K-virus biological agent was developed by Yang Ping and his team members after countless efforts, and it carried everyone's expectations. Yang Ping knew that this was Sisi's only life-saving straw, and he had to ensure that the injection process was foolproof.
Yang Ping checked it carefully again to make sure there was nothing wrong. Then, he gently pushed the piston of the syringe. At this moment, everyone's hearts were in their throats.
The injection began, and Yang Ping pushed the syringe carefully, fearing that something might go wrong. The viral biological agent slowly flowed into Sisi's body, as if a warm current of life was surging in her blood vessels. Everyone held their breath, nervous.
Watching Sisi's changes carefully.
With the injection of the virus, Sisi's expression did not change. Everything seemed so normal. Sisi felt as if she had received an ordinary painkiller injection, without any discomfort.
Yang Ping was always paying attention to Sisi's vital signs. The numbers on the ECG monitor kept beating, showing important indicators such as her heart rate, blood pressure and blood oxygen saturation. He knew that this battle had just begun, and what would come next
During this time, he must always remain vigilant and be ready to deal with possible unexpected situations.
After the injection, everyone's tense nerves relaxed slightly, but they still did not dare to be careless. Sisi's condition may change at any time, and they must stay awake and prepared at all times.
"Get up and go back to the ward to rest." Yang Ping breathed a sigh of relief. At least there were no accidents in the early days after the injection.
Professor Zhang said while packing the portable refrigerator: "Then let's go back first and contact us anytime if we need anything."
Yang Ping thanked Professor Zhang's team and helped Sisi up. Seeing Sisi getting up from the hospital bed with great energy, those interns thought that the oppressive feeling of being faced with an enemy just now was really unnecessary. Isn't it good now?
Nothing happened.
But Yang Ping knew in his heart that the real dangerous moment had not yet come. After the virus enters the human body, it takes a while for the virus to react, not immediately. Just like a cold, it often takes a few days for cold symptoms to appear after being infected with the virus.
Yang Ping decided to stay vigil in the department and closely observe Sisi's changes. He knew that the next time would be their most critical test. Sisi's condition may change in a short period of time, and they must be fully prepared.
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The nurses on duty worked in shifts and guarded her 24 hours a day. They were always paying attention to Sisi's vital signs and recording every subtle change.
At around one o'clock in the morning, Sisi's mother found that her daughter's body was scalding hot, as if surrounded by a ball of fire. She panicked and called the nurse. The nurse who was dedicated to accompanying her 24 hours a day in the ward immediately took Sisi's temperature. The results showed that Sisi's body temperature was
Her body temperature was as high as 42 degrees Celsius. This kind of questioning has reached the limit that the human body can bear. After hearing the news, Yang Ping rushed over and immediately gave a verbal medical order to give Sisi an antipyretic injection.
At the same time, he immediately ordered the use of ice caps and ice blankets for Sisi, using this physical cooling method to protect her brain and important organs of the body. He knew that high fever would cause irreversible damage to the brain and even be life-threatening. Therefore,
, the body temperature must be lowered as soon as possible.
Soon, Sisi suffered from convulsions due to high fever and entered a state of unconsciousness. Sisi's body kept twitching and her mouth began to utter nonsense.
Yang Ping stood by the bed and paid close attention to Sisi's vital signs, ready to deal with possible emergencies at any time.
All the antipyretics were of no use at all, and even the method of nasal feeding the Chinese patent medicine Angong Niuhuang Pills was used, but it had no effect.
The only thing that worked was the ice cap and ice blanket. The high fever lasted all night. If it weren't for the physical cooling effect of the ice cap and ice blanket, Sisi would have been unable to hold on. Yang Ping and the nurses also waited all night. They stayed up.
Their eyes were red and they were exhausted, but they never left their posts. They knew they could not slack off in the slightest.
Sisi's high fever was obviously an immune response triggered by the injection of the virus into her body. This brand-new virus was like an alien invader to Sisi's immune system, and her immune system activated a wide range of defense mechanisms in panic.
, the body temperature regulation center loses control, causing high fever.
In a high fever state, the oxygen consumption of brain tissue increases sharply and blood flow accelerates, putting the brain at risk of relative hypoxia. In order to protect this most important organ, the use of ice caps becomes crucial. It uses physical means
Reduce the temperature of the head, thereby slowing down the metabolic rate of brain tissue, reducing oxygen consumption, and ensuring a relatively sufficient blood supply to the brain.
This process, like animal hibernation, is a self-protection mechanism. In winter when food is scarce, animals reduce their need for food by lowering their metabolic rate and body temperature to survive the difficulties. Similarly, the use of ice caps uses a similar method
strategies to cope with this sudden oxygen shortage.
Yang Ping knew very well that this fight was not only a battle against the virus, but also a race against time. He always maintained a high degree of vigilance and carefully observed every subtle change of Sisi. Her breathing, heartbeat, blood pressure
, even every expression touches his heart.
Any negligence may be fatal.
However, the high fever persisted, and if this continued, even the ice cap and ice blanket would not help, because the ice cap and ice blanket only passively cooled the body, and Sisi's body would sooner or later collapse in the battle between the virus and the immune system.