Sisi's high fever persisted, and Yang Ping could only temporarily use an ice cap and ice blanket to physically cool down. By the next morning, Sisi's fever showed no sign of subsidence.
In order to keep the respiratory tract open, the nurse has intubated Sisi's trachea, and has also prepared a ventilator, ECMO and other life support nearby, which can be used at any time when needed.
Yang Ping observed the changes in Sisi's condition while thinking about countermeasures. There was no precedent for what kind of reaction this virus would have on the human body.
The impact of the source virus on the human body no longer has any reference value, because after the K factor is implanted, the symptoms caused by the new virus are completely absent from the source virus. The source virus can cause mild flu symptoms at most, and the current K virus actually causes 42 degrees Celsius.
Persistent high fever.
Yang Ping's current thinking is very clear. Use physical cooling to lower body temperature as much as possible, reduce brain tissue metabolism, and protect brain tissue and other important organs from damage. Maintain Sisi's body fluid balance and electrolyte balance, and maintain her normal nutrition and energy supply.
.As for reducing fever, leave it to the body’s own immunity.
These viruses have been castrated in their ability to replicate, so as long as Sisi can withstand the survival time of the virus itself, after the viruses die naturally one after another, the number of viruses will gradually decrease, and the high fever will naturally subside.
In fact, this is similar to the treatment idea for most diseases. Symptomatic treatment relieves symptoms and ensures life safety. Treatment of causes is left to the body’s own immunity.
Yang Ping and Song Zimo stayed up all night. When Xu Zhiliang, Xia Shu, and Dr. Jin came to work in the morning, they offered to change shifts with them. Now was the high fever period. Yang Ping did not dare to relax. He asked Dr. Jin to stay by the bedside. Xu Zhiliang and
Xia Shu went to the department to handle the work. He and Song Zimo took turns sleeping and resting in the companion bed in the ward. After all, we still don’t know how the disease will develop in the future, and whether we can sleep for a while, and try to maintain sufficient physical strength to cope with the future illness.
change.
There were also three nurses, several doctors and masters who participated in Sisi's experiment. Yang Ping asked them to change shifts, with new staff taking over their work, and let them go back to rest.
Sisi's parents were allowed to come in for a short visit, but they were not allowed to stay in the ward for a long time. After all, this kind of intensive care and treatment is not child's play, and any extra personnel would interfere with medical activities.
Seeing their daughter lying unconscious on the bed, the couple just burst into tears and felt extremely painful, but they could not speak out or interfere with Professor Yang's normal treatment. After only visiting for a few minutes, Sisi's father pulled the trigger.
Looking at her mother: "Let's go out."
On the ECG monitor at the bedside, the heart rate number is constantly rising, which is much higher than normal. Every time the body temperature rises by one degree Celsius, the heart rate will increase by 12-18 beats. Now Sisi's heart rate is already 150 beats. This high heart rate maintains
Once the time is too long, the heart will fail.
This is just like a car's engine. Maintaining the maximum speed for a long time is likely to cause the cylinder to explode. The same is true for the heart. Maintaining a heart rate much higher than normal for a long time can easily lead to arrhythmia, heart failure, and cardiac arrest.
Yang Ping and Song Zimo were sleeping and resting on the companion bed next to them. Dr. Jin, who was on duty, saw that the heart rate had been slowly rising. It was now possible to exceed 160 beats/min. He was not sure whether it needed to be dealt with, but he did not dare.
He took the decision without permission, so he had to wake up Yang Ping who was resting.
After Yang Ping woke up, he looked at the numbers on the monitor, and then listened to Sisi's heart with a stethoscope. After listening to the heart, he stared at the ECG waveform on the monitor and remained calm.
"What should I do? What if I don't use drugs to lower my heart rate?" Dr. Jin was worried next to him, and Song Zimo also got up and stood next to him.
In fact, when facing a patient's life-and-death challenge, the ability of the attending doctor is extremely tested. He needs to combine his knowledge, experience and the patient's clinical performance to make accurate judgments. This judgment is related to the patient's life and death.
Yang Ping observed the electrocardiogram for five minutes without saying anything. Dr. Jin and Song Zimo were also worried. The heart rate on the monitor was now fluctuating around 160 beats/min, and there was no guarantee whether it would continue to rise.
In this case, the heart can collapse at any time, so it is very difficult to make a choice at this time.
Yang Ping finally spoke, and he shook his head: "No! Keep observing! If you lower the heart rate, the drugs that lower the heart rate will inhibit myocardial contractility and lower blood pressure. Once used, the heart rate will drop, but the brain will be damaged due to weak perfusion.
Insufficient blood supply can easily cause irreversible damage to brain tissue. This is likely to result in a large area of brain tissue death before the heart collapses."
Dr. Jin and Song Zimo thought about it and found that this was indeed the truth. Yang Ping thought more carefully and profoundly.
"What should we do now?" Dr. Jin couldn't help but ask.
"Now we can only let her carry it on her own and let her own immunity deal with it all. We can only deal with and rescue sudden dangers and provide life support. We can't help with other things. Everyone must stay calm.
and rationality, a mistake in handling details will cause irreparable consequences."
At this time, Sisi twitched from time to time, and Yang Ping told the nurse to strengthen respiratory care to prevent suffocation during the convulsions. Anyway, keep an eye on the two vital organs of the heart and lungs, and deal with them immediately if any abnormalities occur.
This independent ward is fully equipped with all kinds of high-end rescue equipment. It was originally intended to be used as an independent ICU for the surgical institute. The decoration and equipment have been completed, but the staff is not in place yet, so it is temporarily vacant. It comes in handy now.
Create a laboratory ward for Sisi to avoid putting Sisi in the ICU and putting huge pressure on the ICU doctors' care.
"Is it okay to twitch like this?" Dr. Jin asked again. After all, Dr. Jin had been an orthopedic surgeon for so many years and didn't have much experience with this kind of febrile convulsions in children, so he felt a little worried.
This chapter is not finished yet, please click on the next page to continue reading the exciting content! Yang Ping said reassuringly: "Don't worry, leave the equipment here and let her pump. Now strengthen the monitoring of the heart and lungs, and pay attention to replenishing fluids and energy."
, we helped her carry it over."
After saying that, Yang Ping lay down on the accompanying bed to sleep again. Dr. Jin was very smart and practical, and Yang Ping was very reassured by him. If it were other young doctors, Yang Ping would definitely not be reassured. Inexperience can easily lead to misjudgment.
Some potential risks lack adequate identification and early warning capabilities.
Around four o'clock in the afternoon, Sisi's body temperature began to drop, which indicated that the virus began to die in the body one after another. The tug-of-war between the immune system and the virus began to tilt towards the immune system, and the virus began to lose.
This is good news. Not only is Sisi likely to escape death, but there is also a very important point. Although the impact of the virus on the human body is very different from the source virus, they are probably not the same type of virus, that is, K factor.
The addition of completely changed the character of the virus.
It can be initially estimated that the K virus is a completely new virus to the human body. The human body cannot produce antibodies against it and can only rely on excessive and extensive immunity to fight against it. The risk of this kind of confrontation is extremely high. Once it fails, the human body will
Collapse. Fortunately, these viruses no longer have the ability to replicate, and one less person dies, so their combat effectiveness is extremely limited.
From the injection of K virus to the current downward trend in body temperature, the nurse took a lot of Sisi's blood samples, which are used for various tests to dynamically monitor the changes in various indicators of the human body under the influence of the virus.
In fact, some of the testing reagents for these blood samples are brand new and were specially manufactured for this laboratory. This is because existing off-the-shelf testing reagents cannot detect many new indicators, such as the detection of markers for these viruses.
I don’t know if some viruses can be found in blood samples for research, especially to study whether viruses mutate in the body. Because these viruses do not have the ability to replicate, the mutations will not be inherited and will be difficult to capture.
After her body temperature dropped, Sisi sweated a lot, and the entire sheet was soaked with sweat. The nurse changed the sheets, put Sisi into dry clothes, and increased the amount of fluids to maintain the fluid balance.
On the ECG monitor, the heart rate slowly dropped as the body temperature dropped, and Yang Ping breathed a sigh of relief temporarily.
---
Nandu Medical University, the Virology Laboratory and the Digital Medicine Laboratory are working intensively. After receiving the data from this experiment, they immediately began to make corrections to the K virus and the experiment.
The digital medical laboratory's intelligent model virtual deduction was performed hundreds of thousands of times. The possibility of such a high fever was extremely low, less than one in 100,000. For something with such a low probability to happen to Sisi, or her
If you are unlucky and encounter this one in 100,000 probability, or the model prediction is wrong, the actual probability of such a high-risk outcome is much higher than the model prediction.
Of course, science cannot be left to luck, so Professor He and his team assumed that the reason was the latter, and they began to check and improve the model.
The data from this experiment is very valuable. It is not an animal experiment, but direct clinical experimental data, which is of great value in correcting the model.
Professor He's team improved their model, and Professor Zhang Zhiwei was not idle either. They began to further analyze the structure of the virus, where the K factor should be implanted, and what else needs to be done on the genes of the source virus.
Such changes, these are issues that should be reflected upon.
They must re-analyze and summarize the structure of the virus, and it is best to make theoretical revisions to the implantation of each part based on the experimental data.
Moreover, Professor Zhang’s team also needs to search for the K virus in the blood samples sent over. Although this task is very difficult. It is difficult to find the virus in the blood now, but they also want to try, because as long as they can find the virus, they can observe the virus.
Whether mutations have occurred after entering the human body, whether there have been any changes, and whether the implanted K factor is still functioning.
---
Sisi was still in a state of confusion, but her vital signs were stable, which gave Yang Ping great confidence.
He began to puncture Sisi's liver and lung tumors, and carried out precise punctures under the supervision of navigation equipment, so that some tumor cells could be removed. These tumor cells were then taken to the laboratory for analysis under an electron microscope.
This can confirm whether the K virus has successfully infected tumor cells. If they have successfully infected tumor cells, whether they have successfully initiated the apoptosis program of tumor cells. If they have initiated the apoptosis program, what is the process like.
This analysis must target tumor cells, there is no other way.
Yang Ping knew that Sisi had just escaped from death, and it was still uncertain whether she could escape. Performing various punctures at this time would undoubtedly aggravate her injuries. However, if she did not seize this opportunity to perform punctures, once the opportunity was missed, even if
Even if the virus infects tumor cells, it is impossible to obtain the true status of these tumor cells in the early, middle and late stages after infection.
To save her, there must be no soft-heartedness at this time and everything must be based on rational principles.
As long as the metastases could be punctured, Yang Ping punctured all the tumors and took many specimens and sent them to the electron microscope laboratory of Nandu Medical University for personal observation.
Under the electron microscope, Yang Ping searched for specimens one by one, which required a lot of patience. Because the virus was attacked by the human immune system during transportation, it was unknown how many tumor cells it could successfully infect.
Therefore, some of the specimens collected now may be normal cells and some may be tumor cells, but they may not be infected because the infected cells may not be collected at all.
Yang Ping can only find specimens one by one in person. This work cannot be replaced by software models or artificial intelligence, because both software models and artificial intelligence must be based on doctors' data. These brand-new experiments have no history.
Data feeds such models, and these models are simply useless.
After looking for hundreds of pictures, Yang Ping finally found an abnormal tumor cell. He immediately took out the picture of this cell for study. He found that this cell was a cell infected by the virus because it also contained the protein structure of the K virus.
.
Unfortunately, this cell did not undergo apoptosis, that is, the K virus did not initiate its apoptosis program. Whether it did not enter the initiation process or failed to initiate at all is currently unknown.
Only by continuing to search, and only by finding more of these virus-infected cells, can the problem be explained. If all cells do not enter the apoptosis program, then it is possible that these viruses have not initiated the apoptosis program of tumor cells.
If these tumor cells are in different states, even if only one cell enters the apoptosis program, it means that the K virus can infect the tumor cells and start its apoptosis program.
Yang Ping decided to continue searching, and Song Zimo took several doctors and masters to help Yang Ping search.
Yang Ping taught them the knowledge of looking at electron microscopy pictures and asked them to relax the indications, but if they felt suspicious, they would submit them to Yang Ping for review, so as to reduce the risk of missing specimens.