In the next few days, Bai Ye was immersed in the laboratory all day long. Bai Ye had a reference for the research on Salvia miltiorrhiza and Panax notoginseng.
Because these two drugs are actually used a lot, they have already gone through the stage of modern research in clinical practice.
Of course, the properties of traditional Chinese medicine are too complex and there are too many compounds in them. It is really a very difficult and cumbersome process to find them all.
It has to go through continuous separation and extraction, and then various processes to separate all the components of the drug, and then analyze the special molecules.
The preparation method of Danqi Huoxue Pills is very simple. After Bai Ye bought Salvia miltiorrhiza and Panax notoginseng from the market, after processing, Bai Ye did not make them into pills, but into a decoction.
Because pill analysis is inconvenient, it is better to use decoction for analysis.
Bai Ye prepared the decoction with the separation reagent according to the method written in the information, then continuously added the medicine into it, and then distilled and extracted it to obtain some water-soluble substances...
However, Bai Ye discovered a very important problem, that is, after the two traditional Chinese medicines are added, their original chemical structures will be changed and chemical reactions will occur to obtain new substances. This will undoubtedly increase the difficulty of extraction.
So Bai Ye extracted separately and made Salvia miltiorrhiza first. He crushed Salvia miltiorrhiza into coarse powder, added ethanol and heated under reflux for extraction three times, filtered, combined the filtrate, recovered the ethanol under reduced pressure, and concentrated it into a thick paste with a relative density of 1.30~1.35, and then used
Heat hot water to 80c...
This is a tedious process, but the harvest is great. Bai Ye looked at the sample he got: orange-red crystals. This should be the so-called cryptotanshinone. Bai Ye turned to aluminum oxide...
In fact, the extraction and separation of traditional Chinese medicine is a very important and critical channel for the modernization of traditional Chinese medicine.
Exploring and studying the active ingredients in traditional Chinese medicine can discover active substances with novel structures or new mechanisms, thereby finding new drugs with high efficiency and low toxicity, which is of great significance.
Therefore, after these days of research, Bai Ye discovered that Mr. Liu's purpose should be to cultivate this idea of his own. As for the actual separation and extraction of the two drugs, Salvia miltiorrhiza and Panax notoginseng?
These two drugs are old-fashioned and have been studied by many people. The technology is very complete. As long as you follow the process step by step, you can get the results.
Bai Ye basically spent the past few days in the laboratory and library and the office of Zhou Mao, dean of the Department of Traditional Chinese Medicine.
When Bai Ye encountered a problem, he went to the library to look it up. If he couldn't solve it, he checked it online, and finally consulted Zhou Mao.
Zhou Mao is not a doctor, but a graduate student of Beijing Pharmaceutical University. After graduation, he came here to work as a teacher and also did many projects. He and Zhang Hanlin are two different people. Although he is also doing scientific research at the school, for him,
The school is a platform, a platform that serves itself.
As the dean of the School of Pharmacy, he has maintained long-term cooperative relationships with many pharmaceutical companies, such as Zhennan Pharmaceutical, and often helps them do some drug research, such as drug ingredient analysis, drug toxicity identification, etc.
Bai Ye has only gotten to know him better in recent days. He is an economically minded scientific researcher. It is said that he has set up a small studio outside to undertake such outsourcing projects. Many of his graduate students have been working since graduation.
Just follow him.
He also applied for patents for some small discoveries in his studio and sold them to pharmaceutical companies. It can be said that he is the first person from Jinxi University of Traditional Chinese Medicine to drive a car worth more than 500,000 yuan openly.
These were said by others, but Zhou Mao did not deny it. He openly admitted that he had done certain things.
But these do not affect his work, and on the contrary, many graduates are contacted by Zhou Mao every year for jobs and units, so he is still very popular in the graduate circle of the School of Traditional Chinese Medicine.
During this period of time together, Bai Ye and he got to know each other relatively well, and Zhou Mao was also very skilled, but his professionalism was very solid. In his words, what is ability? It is your ability to establish yourself peacefully. If you can even
This is all gone, what else do you have?
I have to say that focusing on economic construction can indeed stimulate the development of science and technology. Take Zhou Mao, he has won two provincial progress awards, but he sold the patent after he changed hands, and used the money to buy a car.
Land Cruiser drove into the campus.
It originally caused a lot of jokes at the time, but the next year, Zhou Mao sold a patent again, this time for more money than last time.
However, Zhou Mao was very patient with Bai Ye's advice and told Bai Ye a lot of things, such as Salvia miltiorrhiza and Panax notoginseng. Zhou Mao had also done extraction and separation, so he was very skilled.
I personally taught Bai Ye by words and deeds in the laboratory, and told Bai Ye some precautions and things that needed attention.
Especially things that are easy to miss and pull down. In Zhou Mao’s words, if you follow the path of others, you can only get the results of others. But if you follow the path of different people, you may get results.
There are different results.
Invention and creation are about discovering subtle differences and starting from the details.
In the past few days, Bai Ye has basically been in the library besides the laboratory, but he has gained a lot! Especially under the condition of ten times the experience bonus, Bai Ye's skills have been directly improved.
Scientific research skills: separation and extraction: lv3: 6999/10000.
The improvement of separation and extraction skills made Bai Ye's separation and extraction work significantly faster.
He followed Zhou Mao's methods and ideas, as well as different people's ideas and methods to do the extraction work from multiple angles.
However, the two traditional Chinese medicines of Salvia miltiorrhiza and Panax notoginseng are too common, and people have not studied them well, so after Bai Ye tried many times, he still did not receive any goods. In addition to further improving his separation and extraction skills, he reached lv4.
grade, others still have not received the goods.
Therefore, Bai Ye decided not to study the two drugs separately, but decided to combine them and try the substances after the reaction of the two drugs to see if he could get something different.
Two days later, Bai Ye was able to separate some common substances using some of the techniques and instruments he had learned these days. The combination of Salvia miltiorrhiza and Panax notoginseng was very common, and it was not uncommon for people to analyze it.
For example, Compound Danshen Dropping Pills is a patent medicine made from extracts of Panax notoginseng and Salvia miltiorrhiza. It mainly uses Danshensu and Panax notoginseng total saponins. This medicine has been widely used for coronary heart disease in China, South Korea, Russia and other places.
Treatment of cerebral thrombosis, etc.
After Bai Ye extracted those substances, he suddenly came up with an idea. Since they only used salvia miltiorrhiza and Panax notoginseng saponins, were the other substances useless?
Perhaps we can study Danqi Huoxue Pills from the perspective of Compound Danshen Dropping Pills.
So, Bai Ye went directly to the drugstore to buy the drug, and then began to analyze it.
Compound Danshen Dropping Pills are widely used clinically, and most importantly, its safety and drug toxicity analysis have shown no problems in a large number of clinical trials.
Then Bai Ye suddenly understood something.
Teacher Liu’s purpose is not to allow himself to study this mature product, but to allow himself to understand the modern development of traditional Chinese medicine by comparing it with the mature compound Danshen Dropping Pills when studying Danqi Huoxue Pills.
For example, Danqi Huoxue Pills is just a traditional Chinese medicine prescription, while Compound Danshen Dropping Pills are drugs that can be widely popular in foreign markets.
Where is the gap between them? Is it obvious that they are extracting the effective ingredients and then proving their effectiveness through experiments?
The advantage of Compound Danshen Dropping Pills is to take the essence and remove the dross, thereby achieving a relatively mature and modern product!
Bai Ye suddenly became curious and opened the development history of Compound Danshen Dropping Pills. He was surprised to find that his mentor, Academician Liu Boli, was the person in charge of this project and the first prize winner of the National Science and Technology Progress Award in 2003.
Bai Ye took a deep breath. It turns out that if he hadn't accidentally hit it, he probably wouldn't have discovered the teacher's intention.
But...Bai Ye also has a new research direction.
Since Compound Salvia Dripping Pills removes the dross and takes out one of the essences, then if I do the opposite, think in reverse, find out the dross, and truly discover the reason why it was removed.
Will there be new discoveries?
Discovering something that is beneficial to mankind is progress and invention, but inventing something that is harmful and letting people avoid it is also a kind of progress! Moreover, many poisonous things are increasingly being discovered.