Chapter 54 Malaria

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Control... variables?

Everyone present was an elite scholar who had received preparatory education from the academy. After thinking for a while with a frown, they quickly understood the general meaning of Li Ang.

“It’s mosquitoes that cause malaria, not evil spirits?”

Song Shaoyuan and Zhai Yiming murmured to themselves with wide eyes,

Ji Linglang was thoughtful,

Yang Yu looked at Li Ang curiously. Regardless of whether what he said was right or not, the theory that mosquitoes cause malaria is a novel theory other than evil spirits, malaria ghosts, and disloyalty and unfilial piety.

The servant standing at the door still maintained a reserved and respectful posture, and did not make any movements.

Just a twitch of his ears, as if he heard the instructions from the next room, he respectfully raised his hands and asked: "So, Xiaolangjun, do you have any evidence?"

"Evidence, it can also be obtained by controlling variables."

Li Ang thought for a while and said: "If your master is free, you can send people to visit various cities to inquire about the terrain conditions of each city, and summarize the number of residents in the cities who have suffered from malaria and died of malaria.

A residential area with high terrain, no water, no grass, and few mosquitoes.

A residential area with high terrain, surrounded by water, grass and mosquitoes.

A residential area with low terrain, no water, no grass, and few mosquitoes.

It is a low-lying residential area surrounded by water, grass and mosquitoes.

As long as enough cities are visited and the sample size is large enough,

It's easy to find out if and how malaria is related to aquatic weed mosquitoes."

"this..."

The servant frowned and said, "Isn't it too troublesome? Chang'an No. 108 has a population of three million..."

"When your master asks, I'm just giving you a suggestion."

Li Ang said casually: "There are ways to get results faster.

When I visited Chang'an just now, I noticed that there are drainage ditches and small bridges on one or both sides of the streets in Chang'an.

These ditches are about one foot wide and are all open ditches exposed to the sun.

Coupled with the slow water flow, mosquitoes can easily lay eggs in the ditch and hatch their larvae, thus producing more mosquitoes.

In order to prescribe the right medicine, we must first select a large area of ​​​​the city, cover the city's drainage ditch with bluestone slabs, and turn the open ditch into a dark ditch.

In the underground ditch, hollow wire baffles are set up at regular intervals. Between the baffles, fork-tailed bettas from Lingnan Road are cultured.

If you don't have a fork-tailed betta, herring or other mosquito-eating fish will do.

An order was then issued to prohibit fishing by pedestrians.

This will reduce the number of mosquitoes that breed in water channels.

Then, mosquito nets and mugwort and artemisia annua were distributed to residents.

Mosquito nets are hung in the bedrooms of adults and children at night, especially those under five years old.

Mugwort and Qinghao are used to fumigate and kill adult mosquitoes.

In addition, people were sent to eradicate low-lying pools and weeds that breed mosquitoes in the city.

A whole set of procedures was completed, and finally when malaria symptoms appeared in summer and autumn, this city was compared with other cities where there were no underground ditches or mosquito control.

Let’s see which Bianfang City has a lower probability of malaria.

It is natural to know the connection between malaria and mosquitoes.

It’s June now, if we act now, we will see initial results in about three to four months.”

Li Ang talked calmly, "By the way, when making the final summary, we must exclude the monks' residences in the market."

The servant asked in surprise: "Why?"

"Because the monks exhale and exhale, they automatically drive away the mosquitoes flying around, and they rarely get sick, so it can be considered a factor that will interfere with the results."

Li Ang said lightly, picked up the chopsticks again, and gave Chai Cuiqiao another piece of vinegar.

In fact, it is only half a month before the preliminary examination of the Academy. It is really troublesome to find a high-end residence with higher terrain in the north of Chang'an City.

But as a doctor, Li Ang has a deeper understanding of diseases, and the more he respects and fears them.

Malaria is one of the diseases that kills the most people in the history of other worlds. It can be said that the history of mankind is the history of malaria.

Some mosquitoes carry a single cell called Plasmodium. When a mosquito bites a human body, the Plasmodium enters the human body, infects the liver, creates thousands of new Plasmodium parasites in the liver, and then begins to invade and infect the blood.

Red blood cells further divide, multiply, and degenerate.

Yes, merozoites transformed from malaria parasites will differentiate into male and female types and can survive in the human body for 60 days.

Once the male and female merozoites are re-inhaled by the mosquito, they will multiply in the mosquito's body and form "gametes", and the gametes will turn into "kinozygotes" and enter the mosquito's stomach wall to form oocysts, and eventually reproduce asexually

They form "sporozoites" and actively enter mosquito saliva to start the next round of infection transmission.

The whole process is extremely cumbersome, complex, and bizarre.

For humans, the garbage released by malaria parasites in the body will trigger the body's immune response, causing alternations of cold and heat, constant sweating, and repeated attacks, leading to anemia, splenomegaly, and organ failure.

'Even based on the most optimistic 1% malaria incidence rate, with the total population of 40 million in Yu State, 4 million people suffer from malaria every year, a large part of whom are under the age of five and have not developed sufficient immunity.

's children.'

Li Ang thought silently: "Without effective treatment, the mortality rate of falciparum malaria is as high as 40%.

And even if it is not malaria, mosquito bites may also spread Japanese encephalitis, dengue fever, filariasis, and yellow fever - Chang'an City, thousands of countries came to Korea,

Traders, livestock, and wild animals from all over the world may become the source of disease."

Before becoming a monk and possessing basic disease resistance, Li Ang had no intention of testing his resistance to influenza diseases.

Seeing that Li Ang spoke in an orderly manner, the servant standing at the door became more respectful and said with cupped hands: "My master said that if you are injured by cold in winter, you will suffer from warm disease in spring, you will be injured by heat in summer, and you will suffer from malaria in autumn.

Autumn is coming soon, and there may not be so much time.

I would like to ask Xiao Langjun if there is a faster way to detect the connection between malaria and mosquitoes."

"Faster?"

Li Ang raised his eyebrows, thought for a while and said: "Then we will spend a lot of money to ask monks from Tingyujing and Xunyunjing who specialize in talismans to write down the Qingfeng Talisman.

Distributed to local residents.

The Breeze Talisman can call up the breeze and repel mosquitoes, and it can also prevent mosquitoes, but it is very expensive - as far as I know, if you ask a monk from the Cloud Patrol Realm to spend all your energy to write a talisman, you will have to start hundreds of times."

The servant still maintained a respectful attitude, "Is there a faster way?"

"Um?"

Song Shaoyuan frowned and said, "How come your master is so extravagant?

We were just chatting privately, so if you knock on the door and disturb us, forget it.

Now my classmate has given two strategies, but you are still aggressive, isn't this a bit inappropriate?"

Although Song Shaoyuan has a loyal character, he is not stupid.

The identity of the other party was unknown, and he very wisely did not say Li Ang's name, but only called Li Ang his "classmate."

Zhai Yiming hesitated and then joined in.

Although he is usually a bit jealous of Li Ang, after all, he is a fellow student from the same hometown, and he cannot watch one of his own being bullied under the eyes of outsiders.

"..."

Li Ang looked at the servant, his eyes quickly became cold, and he said indifferently: "Since your master already knows the answer, why do you need to ask again?

I only remind you that people are doing it and God is watching.

Please come back."

After saying that, Li Ang flicked his sleeves and stopped looking at the servant.

The other party also bowed his head to the end with great respect, turned around and left.

"Um?"

This time it was Song Shaoyuan and others' turn to be confused, and subconsciously asked Li Ang: "What do you mean by telling that servant that his master already knows the answer?"

"What else could it mean,"

Li Ang said indifferently: "I want to figure out the connection between malaria and mosquitoes as quickly as possible, even before autumn comes and malaria breaks out in the city.

Then there is only one way..."

"Employ people."

Ji Linglang elegantly picked up a piece of vinegar and added the next sentence for Li Ang, "With that method of controlling variables,

Using groups of people deliberately being bitten by mosquitoes,

To directly determine whether you will be infected with malaria if you are bitten by a mosquito."

————

In the next room, Qiu Zhen, the medical officer of the Imperial Medical Office, looked at his friend across the table with an angry face, slapped the table and shouted: "Tantai Leshan!"

The academy secretary named Tantai Leshan sat where he was, calmly accepting his friend's anger, "Why is Brother Qiu angry?"

A [insulation note] has been pasted on the wall of the private room, which can isolate the conversation between the two people. Therefore, Qiu Zhen did not suppress his voice and directly shouted: "Are you trying to do what the student next door said, deliberately?

Find a group of people, let them be bitten by mosquitoes, and make them suffer from malaria?!"


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