Chen Shi's illness recovered. Pan Tao took a standard unit of bone marrow given to him by Liu Miqiao and started research. He cultured several lines of bone marrow stem cells and they grew very well.
He began to transplant the first patient.
The effect, hehe, without even a tiny bit of anti-immune inhibitor, newly produced blood cells were found in the blood vessels on the third day.
So exciting.
Pan Tao has been undergoing bone marrow transplantation throughout his life. How often has he not been careful and careful? He was afraid of rejection.
There are several key steps in performing a bone marrow transplant.
The first is matching, which is very difficult. After screening hundreds of specimens, if you can find 3 or 4 loci that match, everyone is happy, and it means that the transplant is likely to be successful.
The second step of chemotherapy kills cancerous white blood cells. In fact, it kills all the white blood cells in the patient's body to make room for transplantation.
This step also includes the third level, the infection level.
The fourth level is the rejection level after transplantation.
This is the most difficult level and the key to success or failure. Almost all patients will have rejection reactions. It depends on the doctor. How to use the medicine is very critical.
Immunity must be suppressed, but it cannot be suppressed completely. The body also needs a certain degree of immunity, otherwise an infection that is difficult to reverse may occur. Once this infection occurs, it is extremely dangerous and the survival rate is very low.
Sometimes, symptoms of infection appear in the morning and no one is there in the afternoon.
Therefore, the biggest problem in transplantation is rejection. Even great experts dare not say that this stage can be easily overcome.
The fifth level is the regeneration of transplanted cells.
For a patient, from the time he enters the hospital to prepare for transplantation to the time of successful transplantation, it can take more than three months at the earliest, with most cases taking about half a year, and even two years.
Now, Pan Tao has several strains of bone marrow stem cells without antigen markers, and he eagerly started experiments. He couldn't bear to try such a good thing without trying it.
He already has 32 patients, and they are all waiting for the results of the first patient.
Good news came.
Newly produced blood cells were detected in the first patient on day 3.
On the 5th day, the number increased linearly; on the 10th day, it doubled. On the 15th day, it doubled again.
On day 21, the patient's blood cells stabilized and remained at normal levels, no longer rising.
In other words, the patient officially recovered in 21 days!
This is an incredible achievement.
Pan Tao helped five patients conduct the second batch of experiments. He was not prepared to wait. After waiting for 10 days after the second batch of surgery, he helped transplant the third batch of 10 people.
When the second batch of patients recovered, he performed transplants on the remaining 16 patients.
This is the first batch of 32 experiments conducted by Academician Pan Tao.
All were successful and no rejection reaction occurred.
This is a great result - however, to add the word "great", there must be another prerequisite, it must have enough bone marrow stem cells without immune markers.
This is a problem.
The first batch of 32 patients almost exhausted his bone marrow stem cells - he kept one cell as a seed and continued to culture it.
The cultivation cycle is a bit long and not unlimited.
He calculated that even if it was used sparingly, each unit of bone marrow could only be used for half a year to treat about 2,000 patients.
Pan Tao treats about 3,600 leukemia patients a year at Jincheng No. 1 Hospital. The future prospects of Antai Hospital are definitely bright, and his goal is to treat 6,000 to 7,000 patients.
Because the shortest hospitalization period for leukemia patients is 30 days, then to treat 6,000 to 7,000 people a year, 300 beds are indeed needed.
Pan Tao has 3,4,000 patients in Jincheng No. 1 Hospital every year, and he has 500 hospital beds. The main reason is that the hospitalization period of the patients is too long.
Now that the hospitalization time has been shortened, Antai Hospital has prepared 300 beds, which can basically meet the needs.
"Liu Muqiao, here's the problem, there's not enough bone marrow. You have a lot of connections, can you provide me with two or three bone marrows every year?"
On this day, Pan Tao's paper was published, and Pan Tao's paper was published in the Chinese journal "Hematology", and it was titled "Special Guest". He came to report to Liu Muqiao.
Originally, he was going to collaborate with Liu Muqiao on writing this article, but Liu Muqiao refused.
"I don't want to be named, let alone say that I am a bone marrow provider. You have to keep it secret." That's what Liu Maqiao said at the time.
Today, he showed the article to Liu Muqiao.
This is an achievement, a great achievement. If the supply of bone marrow is satisfied, it will be equivalent to conquering the treatment of leukemia.
His bone marrow stem cell culture can only be used for half a year, because the proliferation of cells is limited outside the body and cannot be multiplied indefinitely outside the body.
Academician Pan Tao originally hoped to obtain bone marrow from the cured patient, but he was disappointed. After transplanting the stem cells, after a period of reproduction, the patient's bone marrow cells reappeared with his own antigen markers.
In this way, there is only one way, and the only way is to obtain bone marrow cells without antigen markers through Liu Miqiao.
Liu Muqiao smiled bitterly and said: "How much do you need in a year?"
Academician Pan Tao said: "Save some money, just two or three standard units."
Liu Muqiao thought for a while, it's not difficult to have two units, isn't it just donating bone marrow twice?
Donating bone marrow is a little more complicated than blood, but generally speaking, it is harmless to the human body. There will be no problem if a body like Liu Maqiao donates it four times a year.
"I divided the patients into two parts. One part used the original transplantation method, and the other part was difficult to match, or the prognosis was very poor. I used the bone marrow culture medium you provided."
Pan Tao explains.
Liu Muqiao nodded and said: "I can only promise to provide you with two standard units of bone marrow every year. If it's more, I can't get it."
Professor Pan was overjoyed. He had never thought that Liu Miqiao would have a stable supply of bone marrow.
"What else is there to say? Enough, enough. I will make good use of this opportunity to make the Department of Hematology the largest specialty."
Pan Tao was very glad that he made the right decision and came to Antai Hospital. At that time, he agreed to work at Antai Hospital in order to get the bone marrow from Liu Muchiao's unit. He never thought that Liu Muchiao could get a second job, let alone him.
I can give him two units every year.
It’s so exciting. You can definitely give it a try and have the conditions to build the largest hematology department in the country.
There are two conditions for achieving this goal. One is the reputation of Academician Pan Tao, and the other is that the Hematology Department of Antai Hospital has bone marrow that can be mismatched. Moreover, several types of leukemia that had a low success rate of transplantation in the past have a better chance of being cured here.
A lot.
Academician Pan Tao returned to the department as if he had received chicken blood, and he began to arrange for the second batch of patients to be admitted to the hospital for transplantation.
This time, the number of patients he is preparing to transplant has more than doubled to 72.
Liu Muqiao received a call from Sun Tao. Sun Tao said, "Liu Muqiao, I don't know where Pan Tao got his confidence. This old guy actually restricted me to meet his request of 300 beds within 3 months. Do you think he is a little arrogant?"
Ah."
This chapter has been completed!